Exosomes and Their Therapeutic Potentials of Stem Cells
Exosomes, a group of vesicles originating from the multivesicular bodies (MVBs), are released into the extracellular space when MVBs fuse with the plasma membrane. Numerous studies indicate that exosomes play important roles in cell-to-cell communication, and exosomes from specific cell types and co...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/7653489 |
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| author | Chao Han Xuan Sun Ling Liu Haiyang Jiang Yan Shen Xiaoyun Xu Jie Li Guoxin Zhang Jinsha Huang Zhicheng Lin Nian Xiong Tao Wang |
| author_facet | Chao Han Xuan Sun Ling Liu Haiyang Jiang Yan Shen Xiaoyun Xu Jie Li Guoxin Zhang Jinsha Huang Zhicheng Lin Nian Xiong Tao Wang |
| author_sort | Chao Han |
| collection | DOAJ |
| description | Exosomes, a group of vesicles originating from the multivesicular bodies (MVBs), are released into the extracellular space when MVBs fuse with the plasma membrane. Numerous studies indicate that exosomes play important roles in cell-to-cell communication, and exosomes from specific cell types and conditions display multiple functions such as exerting positive effects on regeneration in many tissues. It is widely accepted that the therapeutic potential of stem cells may be mediated largely by the paracrine factors, so harnessing the paracrine effects of stem and progenitor cells without affecting these living, replicating, and potentially pluripotent cell populations is an advantage in terms of safety and complexity. Ascending evidence indicated that exosomes might be the main components of paracrine factors; thus, understanding the role of exosomes in each subtype of stem cells is far-reaching. In this review, we discuss the functions of exosomes from different types of stem cells and emphasize the therapeutic potentials of exosomes, providing an alternative way of developing strategies to cure diseases. |
| format | Article |
| id | doaj-art-6b501bf06dc1485ab95a4422b520f0a6 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-6b501bf06dc1485ab95a4422b520f0a62025-02-03T06:05:57ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/76534897653489Exosomes and Their Therapeutic Potentials of Stem CellsChao Han0Xuan Sun1Ling Liu2Haiyang Jiang3Yan Shen4Xiaoyun Xu5Jie Li6Guoxin Zhang7Jinsha Huang8Zhicheng Lin9Nian Xiong10Tao Wang11Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, ChinaDepartment of Interventional Neuroradiology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, ChinaDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, ChinaDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, ChinaDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, ChinaDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, ChinaDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, ChinaDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, ChinaDepartment of Psychiatry, Harvard Medical School, Division of Alcohol and Drug Abuse, and Mailman Neuroscience Research Center, McLean Hospital, Belmont, MA 02478, USADepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, ChinaDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, ChinaExosomes, a group of vesicles originating from the multivesicular bodies (MVBs), are released into the extracellular space when MVBs fuse with the plasma membrane. Numerous studies indicate that exosomes play important roles in cell-to-cell communication, and exosomes from specific cell types and conditions display multiple functions such as exerting positive effects on regeneration in many tissues. It is widely accepted that the therapeutic potential of stem cells may be mediated largely by the paracrine factors, so harnessing the paracrine effects of stem and progenitor cells without affecting these living, replicating, and potentially pluripotent cell populations is an advantage in terms of safety and complexity. Ascending evidence indicated that exosomes might be the main components of paracrine factors; thus, understanding the role of exosomes in each subtype of stem cells is far-reaching. In this review, we discuss the functions of exosomes from different types of stem cells and emphasize the therapeutic potentials of exosomes, providing an alternative way of developing strategies to cure diseases.http://dx.doi.org/10.1155/2016/7653489 |
| spellingShingle | Chao Han Xuan Sun Ling Liu Haiyang Jiang Yan Shen Xiaoyun Xu Jie Li Guoxin Zhang Jinsha Huang Zhicheng Lin Nian Xiong Tao Wang Exosomes and Their Therapeutic Potentials of Stem Cells Stem Cells International |
| title | Exosomes and Their Therapeutic Potentials of Stem Cells |
| title_full | Exosomes and Their Therapeutic Potentials of Stem Cells |
| title_fullStr | Exosomes and Their Therapeutic Potentials of Stem Cells |
| title_full_unstemmed | Exosomes and Their Therapeutic Potentials of Stem Cells |
| title_short | Exosomes and Their Therapeutic Potentials of Stem Cells |
| title_sort | exosomes and their therapeutic potentials of stem cells |
| url | http://dx.doi.org/10.1155/2016/7653489 |
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