Non-motor Disorders and their Neuro-anatomical Substrate in Parkinson's Disease
Parkinson's disease remains the second most common degenerative disorder of the central nervous system after Alzheimer's. Although it was initially described as a condition with an exclusive motor disorder, it has been shown that non-motor disorders of Parkinson's are an important par...
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| Main Authors: | , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
Universidad de las Ciencias Médicas de Cienfuegos
2024-12-01
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| Series: | Revista Finlay |
| Subjects: | |
| Online Access: | https://revfinlay.sld.cu/index.php/finlay/article/view/1466 |
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| Summary: | Parkinson's disease remains the second most common degenerative disorder of the central nervous system after Alzheimer's. Although it was initially described as a condition with an exclusive motor disorder, it has been shown that non-motor disorders of Parkinson's are an important part of the clinical picture. These include all those disorders that are not motor symptoms: behavioral neuropsychiatric disorders (dementia, depression, anxiety, psychosis); autonomic alteration (postural hypotension, gastrointestinal and genitourinary disorders, diaphoresis); sleep disorders; sensory-motor symptoms (fatigue, restless legs syndrome). Degeneration of non-dopaminergic cellular systems (noradrenergic, serotonergic, and cholinergic) is believed to underlie the development of most non-motor disorders. New studies are necessary to clarify the pathophysiological bases of Parkinson's disease that allow establishing future therapeutic strategies for the follow-up of patients with these disorders. |
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| ISSN: | 2221-2434 |