Different catalytic approaches of Friedländer synthesis of quinolines
Friedländer quinoline synthesis is one of the most important and simplest methods among the various reported methodologies for quinoline synthesis, renowned for its efficiency and versatility. The reaction involves the condensation of a 2-aminobenzaldehyde with a ketone, forming polysubstituted quin...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025000891 |
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| author | Indhu Chandrasekaran S. Sarveswari |
| author_facet | Indhu Chandrasekaran S. Sarveswari |
| author_sort | Indhu Chandrasekaran |
| collection | DOAJ |
| description | Friedländer quinoline synthesis is one of the most important and simplest methods among the various reported methodologies for quinoline synthesis, renowned for its efficiency and versatility. The reaction involves the condensation of a 2-aminobenzaldehyde with a ketone, forming polysubstituted quinolines. This review comprehensively examined diverse catalytic approaches developed to optimize the Friedländer reaction, highlighting recent advancements and their impact on reaction efficiency, selectivity, and environmental sustainability. The discussion encompassed traditional catalysts and emerging catalytic systems, including ionic liquids, metal-organic frameworks, polymers, and nanocatalysts. Additionally, the review addresses the influence of various catalytic environments on reaction outcomes. By collating and critically analyzing recent advancements, this review aims to provide a valuable resource for researchers seeking to leverage these catalytic strategies for synthesizing quinoline derivatives. |
| format | Article |
| id | doaj-art-6b499391dc17431ba239ee974bdea00d |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-6b499391dc17431ba239ee974bdea00d2025-02-02T05:28:00ZengElsevierHeliyon2405-84402025-01-01112e41709Different catalytic approaches of Friedländer synthesis of quinolinesIndhu Chandrasekaran0S. Sarveswari1Department of Chemistry, School of Advanced Sciences, VIT-Vellore, 632014, Tamil Nadu, IndiaCorresponding author.; Department of Chemistry, School of Advanced Sciences, VIT-Vellore, 632014, Tamil Nadu, IndiaFriedländer quinoline synthesis is one of the most important and simplest methods among the various reported methodologies for quinoline synthesis, renowned for its efficiency and versatility. The reaction involves the condensation of a 2-aminobenzaldehyde with a ketone, forming polysubstituted quinolines. This review comprehensively examined diverse catalytic approaches developed to optimize the Friedländer reaction, highlighting recent advancements and their impact on reaction efficiency, selectivity, and environmental sustainability. The discussion encompassed traditional catalysts and emerging catalytic systems, including ionic liquids, metal-organic frameworks, polymers, and nanocatalysts. Additionally, the review addresses the influence of various catalytic environments on reaction outcomes. By collating and critically analyzing recent advancements, this review aims to provide a valuable resource for researchers seeking to leverage these catalytic strategies for synthesizing quinoline derivatives.http://www.sciencedirect.com/science/article/pii/S2405844025000891Friedländer synthesisPolysubstituted quinolinesIonic liquidsNanocatalystsMetal-organic frameworksOrganocatalysts |
| spellingShingle | Indhu Chandrasekaran S. Sarveswari Different catalytic approaches of Friedländer synthesis of quinolines Heliyon Friedländer synthesis Polysubstituted quinolines Ionic liquids Nanocatalysts Metal-organic frameworks Organocatalysts |
| title | Different catalytic approaches of Friedländer synthesis of quinolines |
| title_full | Different catalytic approaches of Friedländer synthesis of quinolines |
| title_fullStr | Different catalytic approaches of Friedländer synthesis of quinolines |
| title_full_unstemmed | Different catalytic approaches of Friedländer synthesis of quinolines |
| title_short | Different catalytic approaches of Friedländer synthesis of quinolines |
| title_sort | different catalytic approaches of friedlander synthesis of quinolines |
| topic | Friedländer synthesis Polysubstituted quinolines Ionic liquids Nanocatalysts Metal-organic frameworks Organocatalysts |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025000891 |
| work_keys_str_mv | AT indhuchandrasekaran differentcatalyticapproachesoffriedlandersynthesisofquinolines AT ssarveswari differentcatalyticapproachesoffriedlandersynthesisofquinolines |