A single-center case-control study of the association between dorsal striatal damage and nicotine addiction
BackgroundSmoking is closely linked to pulmonary diseases, cardiovascular diseases, cancer, and other health issues, posing a significant threat to human health. The essence of smoking addiction lies in nicotine dependence, though the underlying mechanisms remain unclear. Previous studies have sugge...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1553200/full |
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| author | Chuya Jing Chuya Jing Chuya Jing Chuya Jing Chuya Jing Xingkai An Xingkai An Xingkai An Xingkai An Xingkai An Xingkai An Xingkai An Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang |
| author_facet | Chuya Jing Chuya Jing Chuya Jing Chuya Jing Chuya Jing Xingkai An Xingkai An Xingkai An Xingkai An Xingkai An Xingkai An Xingkai An Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang |
| author_sort | Chuya Jing |
| collection | DOAJ |
| description | BackgroundSmoking is closely linked to pulmonary diseases, cardiovascular diseases, cancer, and other health issues, posing a significant threat to human health. The essence of smoking addiction lies in nicotine dependence, though the underlying mechanisms remain unclear. Previous studies have suggested that nicotine addiction is associated with regions such as the insula, globus pallidus, amygdala, and ventral striatum. However, our prior retrospective study indicates that the dorsal striatum may also play a role in nicotine addiction.ObjectiveOur research aims to evaluate the alterations in nicotine addiction among patients with dorsal striatum lesions at 1 month, 3 months, 6 months, and 12 months post-injury.MethodsWe collected data from patients of the First Affiliated Hospital of Xiamen University between August 2021 and August 2024. We screened some patients with dorsal striatum injury and asked a series of questions at the time points of 1 month, 3 months, 6 months, and 12 months after brain injury. Ultimately, 13 patients with dorsal lesions who met the inclusion criteria and a control group of 13 patients with brain injuries in other regions were selected.ResultsWe observed that patients with dorsal striatum damage experienced smoking cessation more readily and earlier compared to the control group. Furthermore, those with more severe dorsal striatum damage might maintain this cessation for longer. Additionally, nicotine dependence scores on the Fagerström Test for Nicotine Dependence (FTND) were lower in patients with dorsal striatum damage compared to the control group, indicating a reduced level of nicotine dependence.ConclusionThis conclusion suggests that the dorsal striatum may be associated with nicotine addiction. |
| format | Article |
| id | doaj-art-6b41e8bef48a4eafa8d7cf73cdbd3d1c |
| institution | DOAJ |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-6b41e8bef48a4eafa8d7cf73cdbd3d1c2025-08-20T03:07:54ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-05-011610.3389/fneur.2025.15532001553200A single-center case-control study of the association between dorsal striatal damage and nicotine addictionChuya Jing0Chuya Jing1Chuya Jing2Chuya Jing3Chuya Jing4Xingkai An5Xingkai An6Xingkai An7Xingkai An8Xingkai An9Xingkai An10Xingkai An11Jie Fang12Jie Fang13Jie Fang14Jie Fang15Jie Fang16Jie Fang17Jie Fang18Jie Fang19Jie Fang20Department of Neurology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaFujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, ChinaXiamen Key Laboratory of Brain Center, Xiamen, ChinaXiamen Medical Quality Control Center for Neurology, Xiamen, ChinaDepartment of Neurology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaFujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, ChinaXiamen Key Laboratory of Brain Center, Xiamen, ChinaXiamen Medical Quality Control Center for Neurology, Xiamen, ChinaFujian Provincial Clinical Research Center for Brain Diseases, Fuzhou, ChinaXiamen Clinical Research Center for Neurological Diseases, Xiamen, ChinaDepartment of Neurology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaFujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, ChinaXiamen Key Laboratory of Brain Center, Xiamen, ChinaXiamen Medical Quality Control Center for Neurology, Xiamen, ChinaFujian Provincial Clinical Research Center for Brain Diseases, Fuzhou, ChinaXiamen Clinical Research Center for Neurological Diseases, Xiamen, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaFujian University of Traditional Chinese Medicine, Fuzhou, ChinaBackgroundSmoking is closely linked to pulmonary diseases, cardiovascular diseases, cancer, and other health issues, posing a significant threat to human health. The essence of smoking addiction lies in nicotine dependence, though the underlying mechanisms remain unclear. Previous studies have suggested that nicotine addiction is associated with regions such as the insula, globus pallidus, amygdala, and ventral striatum. However, our prior retrospective study indicates that the dorsal striatum may also play a role in nicotine addiction.ObjectiveOur research aims to evaluate the alterations in nicotine addiction among patients with dorsal striatum lesions at 1 month, 3 months, 6 months, and 12 months post-injury.MethodsWe collected data from patients of the First Affiliated Hospital of Xiamen University between August 2021 and August 2024. We screened some patients with dorsal striatum injury and asked a series of questions at the time points of 1 month, 3 months, 6 months, and 12 months after brain injury. Ultimately, 13 patients with dorsal lesions who met the inclusion criteria and a control group of 13 patients with brain injuries in other regions were selected.ResultsWe observed that patients with dorsal striatum damage experienced smoking cessation more readily and earlier compared to the control group. Furthermore, those with more severe dorsal striatum damage might maintain this cessation for longer. Additionally, nicotine dependence scores on the Fagerström Test for Nicotine Dependence (FTND) were lower in patients with dorsal striatum damage compared to the control group, indicating a reduced level of nicotine dependence.ConclusionThis conclusion suggests that the dorsal striatum may be associated with nicotine addiction.https://www.frontiersin.org/articles/10.3389/fneur.2025.1553200/fullsmokingnicotine addictiondorsal striatumdamagecessation |
| spellingShingle | Chuya Jing Chuya Jing Chuya Jing Chuya Jing Chuya Jing Xingkai An Xingkai An Xingkai An Xingkai An Xingkai An Xingkai An Xingkai An Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang Jie Fang A single-center case-control study of the association between dorsal striatal damage and nicotine addiction Frontiers in Neurology smoking nicotine addiction dorsal striatum damage cessation |
| title | A single-center case-control study of the association between dorsal striatal damage and nicotine addiction |
| title_full | A single-center case-control study of the association between dorsal striatal damage and nicotine addiction |
| title_fullStr | A single-center case-control study of the association between dorsal striatal damage and nicotine addiction |
| title_full_unstemmed | A single-center case-control study of the association between dorsal striatal damage and nicotine addiction |
| title_short | A single-center case-control study of the association between dorsal striatal damage and nicotine addiction |
| title_sort | single center case control study of the association between dorsal striatal damage and nicotine addiction |
| topic | smoking nicotine addiction dorsal striatum damage cessation |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1553200/full |
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