SPECIAL FEATURES OF CARCINOGENESIS OF COLON ADENOCARCINOMA
Colorectal cancer is one of the most common malignancies and the leading cause of cancer-related death. There are 4 basic colon carcinogenic steps: malignant transformation of adenoma into carcinoma; HNPCC (hereditary nonpolyposis colon cancer); cancer «de novo»; chronic colitis malignant transforma...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/226 |
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| author | G. A. Raskin S. V. Petrov R. V. Orlova |
| author_facet | G. A. Raskin S. V. Petrov R. V. Orlova |
| author_sort | G. A. Raskin |
| collection | DOAJ |
| description | Colorectal cancer is one of the most common malignancies and the leading cause of cancer-related death. There are 4 basic colon carcinogenic steps: malignant transformation of adenoma into carcinoma; HNPCC (hereditary nonpolyposis colon cancer); cancer «de novo»; chronic colitis malignant transformation. All of them, except for Lynch syndrome, are increasingly focused on stem tissue-committed cells as mutation targets and the source of malignancies. Subsequently, cancer stem cells are considered as the cause of chemoresistance of tumors, metastases and relapses. Thus, the study of the cell population can dramatically change approaches to the treatment of patients with colorectal adenocarcinoma. |
| format | Article |
| id | doaj-art-6b4065f8e3e64dd79d9949627f1c2ed6 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-6b4065f8e3e64dd79d9949627f1c2ed62025-08-20T03:35:50ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01147379226SPECIAL FEATURES OF CARCINOGENESIS OF COLON ADENOCARCINOMAG. A. Raskin0S. V. Petrov1R. V. Orlova2Russian Scientific Center of Radiology and Surgical Technologies, Saint-Petersburg; St-Petersburg State UniversityKazan State Medical UniversityRussian Scientific Center of Radiology and Surgical Technologies, Saint-Petersburg; St-Petersburg State UniversityColorectal cancer is one of the most common malignancies and the leading cause of cancer-related death. There are 4 basic colon carcinogenic steps: malignant transformation of adenoma into carcinoma; HNPCC (hereditary nonpolyposis colon cancer); cancer «de novo»; chronic colitis malignant transformation. All of them, except for Lynch syndrome, are increasingly focused on stem tissue-committed cells as mutation targets and the source of malignancies. Subsequently, cancer stem cells are considered as the cause of chemoresistance of tumors, metastases and relapses. Thus, the study of the cell population can dramatically change approaches to the treatment of patients with colorectal adenocarcinoma.https://www.siboncoj.ru/jour/article/view/226colon adenocarcinoma, carcinogenesis, stem cells |
| spellingShingle | G. A. Raskin S. V. Petrov R. V. Orlova SPECIAL FEATURES OF CARCINOGENESIS OF COLON ADENOCARCINOMA Сибирский онкологический журнал colon adenocarcinoma, carcinogenesis, stem cells |
| title | SPECIAL FEATURES OF CARCINOGENESIS OF COLON ADENOCARCINOMA |
| title_full | SPECIAL FEATURES OF CARCINOGENESIS OF COLON ADENOCARCINOMA |
| title_fullStr | SPECIAL FEATURES OF CARCINOGENESIS OF COLON ADENOCARCINOMA |
| title_full_unstemmed | SPECIAL FEATURES OF CARCINOGENESIS OF COLON ADENOCARCINOMA |
| title_short | SPECIAL FEATURES OF CARCINOGENESIS OF COLON ADENOCARCINOMA |
| title_sort | special features of carcinogenesis of colon adenocarcinoma |
| topic | colon adenocarcinoma, carcinogenesis, stem cells |
| url | https://www.siboncoj.ru/jour/article/view/226 |
| work_keys_str_mv | AT garaskin specialfeaturesofcarcinogenesisofcolonadenocarcinoma AT svpetrov specialfeaturesofcarcinogenesisofcolonadenocarcinoma AT rvorlova specialfeaturesofcarcinogenesisofcolonadenocarcinoma |