Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People
Background. The relationship between vitamin D and insulin resistance is still controversial. Many factors could influence this relationship. In addition, this relationship in different genders was still unclear. Methods. A total of 6597 subjects, including 2813 males and 3784 females, were analyzed...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/1216370 |
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| author | Bing Han Qin Li Ningjian Wang Yi Chen Chunfang Zhu Yingchao Chen Fangzhen Xia Zhen Cang Meng Lu Ying Meng Chi Chen Yingli Lu |
| author_facet | Bing Han Qin Li Ningjian Wang Yi Chen Chunfang Zhu Yingchao Chen Fangzhen Xia Zhen Cang Meng Lu Ying Meng Chi Chen Yingli Lu |
| author_sort | Bing Han |
| collection | DOAJ |
| description | Background. The relationship between vitamin D and insulin resistance is still controversial. Many factors could influence this relationship. In addition, this relationship in different genders was still unclear. Methods. A total of 6597 subjects, including 2813 males and 3784 females, were analyzed. The serum levels of 25(OH)D, fasting blood glucose (FBG), fasting insulin, HbA1c, and other metabolic parameters were tested. The waist circumference (WC), weight, and height were also measured. Questionnaires regarding smoking and drinking were collected from these subjects. Results. Serum 25(OH)D was categorized into quartiles. Increasing 25(OH)D levels were associated with reduced trend of homeostasis model assessment of insulin resistance (HOMA-IR) in both males and females. Pearson’s correlation indicated 25(OH)D level was inversely associated with the HOMA-IR for male subjects (r=−0.055, P=0.028) but not for female subjects (r=−0.005, P=0.798). Age, triglyceride (TG), and low-density lipoprotein (LDL) were associated with the vitamin D levels in males and females. In regression analysis, serum 25(OH)D concentration was significantly associated with HOMA-IR only in overweight males. Conclusion. We found an inverse association between 25(OH)D and HOMA-IR in Chinese overweight males. Vitamin D supplementation might be beneficial in this population. However, further clinical trials are needed to confirm this association. |
| format | Article |
| id | doaj-art-6b3c9675331548ccba56858774f7d987 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6b3c9675331548ccba56858774f7d9872025-02-03T01:26:22ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/12163701216370Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese PeopleBing Han0Qin Li1Ningjian Wang2Yi Chen3Chunfang Zhu4Yingchao Chen5Fangzhen Xia6Zhen Cang7Meng Lu8Ying Meng9Chi Chen10Yingli Lu11Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaBackground. The relationship between vitamin D and insulin resistance is still controversial. Many factors could influence this relationship. In addition, this relationship in different genders was still unclear. Methods. A total of 6597 subjects, including 2813 males and 3784 females, were analyzed. The serum levels of 25(OH)D, fasting blood glucose (FBG), fasting insulin, HbA1c, and other metabolic parameters were tested. The waist circumference (WC), weight, and height were also measured. Questionnaires regarding smoking and drinking were collected from these subjects. Results. Serum 25(OH)D was categorized into quartiles. Increasing 25(OH)D levels were associated with reduced trend of homeostasis model assessment of insulin resistance (HOMA-IR) in both males and females. Pearson’s correlation indicated 25(OH)D level was inversely associated with the HOMA-IR for male subjects (r=−0.055, P=0.028) but not for female subjects (r=−0.005, P=0.798). Age, triglyceride (TG), and low-density lipoprotein (LDL) were associated with the vitamin D levels in males and females. In regression analysis, serum 25(OH)D concentration was significantly associated with HOMA-IR only in overweight males. Conclusion. We found an inverse association between 25(OH)D and HOMA-IR in Chinese overweight males. Vitamin D supplementation might be beneficial in this population. However, further clinical trials are needed to confirm this association.http://dx.doi.org/10.1155/2018/1216370 |
| spellingShingle | Bing Han Qin Li Ningjian Wang Yi Chen Chunfang Zhu Yingchao Chen Fangzhen Xia Zhen Cang Meng Lu Ying Meng Chi Chen Yingli Lu Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People International Journal of Endocrinology |
| title | Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People |
| title_full | Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People |
| title_fullStr | Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People |
| title_full_unstemmed | Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People |
| title_short | Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People |
| title_sort | sexual dimorphism for the association between vitamin d and insulin resistance in chinese people |
| url | http://dx.doi.org/10.1155/2018/1216370 |
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