Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease
Background and aims: Fat-soluble vitamins play an important role in the pathogenesis of cardiovascular disease and progression of atherosclerosis. This study aimed at investigating the relationship of the serum levels of alpha-tocopherol and retinol with the extent of coronary lesions in patients wi...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2018/6104169 |
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| author | Carolinne Thaísa de Oliveira Fernandes Miranda Victor Hugo Rezende Duarte Marina Sampaio de Menezes Cruz Mychelle Kytchia Rodrigues Nunes Duarte Jéssica Nayara Góes de Araújo Ayda Maria Quirino Silva dos Santos Juliana Marinho de Oliveira Maria Sanali Moura Oliveira Paiva Adriana Augusto Rezende Mario Hiroyuki Hirata Rosario Dominguez Crespo Hirata Karla Danielly da Silva Ribeiro André Ducati Luchessi Vivian Nogueira Silbiger |
| author_facet | Carolinne Thaísa de Oliveira Fernandes Miranda Victor Hugo Rezende Duarte Marina Sampaio de Menezes Cruz Mychelle Kytchia Rodrigues Nunes Duarte Jéssica Nayara Góes de Araújo Ayda Maria Quirino Silva dos Santos Juliana Marinho de Oliveira Maria Sanali Moura Oliveira Paiva Adriana Augusto Rezende Mario Hiroyuki Hirata Rosario Dominguez Crespo Hirata Karla Danielly da Silva Ribeiro André Ducati Luchessi Vivian Nogueira Silbiger |
| author_sort | Carolinne Thaísa de Oliveira Fernandes Miranda |
| collection | DOAJ |
| description | Background and aims: Fat-soluble vitamins play an important role in the pathogenesis of cardiovascular disease and progression of atherosclerosis. This study aimed at investigating the relationship of the serum levels of alpha-tocopherol and retinol with the extent of coronary lesions in patients with coronary artery disease. Methods. Patients with coronary artery disease (n=177) aged 30–74 years, who underwent their first coronary angiography, were enrolled. The extent of coronary lesions was assessed using the Friesinger index (FI). Accordingly, patients were grouped as follows: FI = 0–4 (n=90), FI = 5–9 (n=50), and FI = 10–15 (n=37). Serum levels of vitamins were determined via high-performance liquid chromatography and serum biochemical analysis. Results. Assessment of FI-based groups revealed that 50.8% patients had a coronary artery lesion to a low extent (FI 0–4). Individuals in this group were younger and had lower glucose and serum alpha-tocopherol levels than the other groups (p<0.05). Low levels of alpha-tocopherol were more frequent in the FI 0–4 group than that in the other groups (p=0.03). No difference was observed between the mean serum retinol levels among the FI-based groups (n=0.492), and the low frequency of retinol was consistent among the FI groups (n=0.348). Conclusions. The low level of alpha-tocopherol together with the presence of dyslipidemia is probably associated with the initial events in atherosclerosis. Increased alpha-tocopherol levels in patients with more extensive coronary artery lesions may have resulted from altered vitamin E metabolism with increased oxidative stress. |
| format | Article |
| id | doaj-art-6b396ec8954c4d55b80168986e179d88 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-6b396ec8954c4d55b80168986e179d882025-02-03T00:59:16ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322018-01-01201810.1155/2018/61041696104169Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery DiseaseCarolinne Thaísa de Oliveira Fernandes Miranda0Victor Hugo Rezende Duarte1Marina Sampaio de Menezes Cruz2Mychelle Kytchia Rodrigues Nunes Duarte3Jéssica Nayara Góes de Araújo4Ayda Maria Quirino Silva dos Santos5Juliana Marinho de Oliveira6Maria Sanali Moura Oliveira Paiva7Adriana Augusto Rezende8Mario Hiroyuki Hirata9Rosario Dominguez Crespo Hirata10Karla Danielly da Silva Ribeiro11André Ducati Luchessi12Vivian Nogueira Silbiger13Laboratory of Bioanalysis and Molecular Biotechnology, Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, BrazilLaboratory of Bioanalysis and Molecular Biotechnology, Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, BrazilLaboratory of Bioanalysis and Molecular Biotechnology, Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, BrazilLaboratory of Bioanalysis and Molecular Biotechnology, Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, BrazilLaboratory of Bioanalysis and Molecular Biotechnology, Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, BrazilLaboratory of Bioanalysis and Molecular Biotechnology, Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, BrazilDepartment Cardiology, Onofre Lopes University Hospital, Natal, BrazilDepartment Cardiology, Onofre Lopes University Hospital, Natal, BrazilMultidisciplinary Laboratory, Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, BrazilDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, São Paulo, BrazilDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, São Paulo, BrazilDepartment of Nutrition, Federal University of Rio Grande do Norte, Natal, BrazilLaboratory of Bioanalysis and Molecular Biotechnology, Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, BrazilLaboratory of Bioanalysis and Molecular Biotechnology, Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, BrazilBackground and aims: Fat-soluble vitamins play an important role in the pathogenesis of cardiovascular disease and progression of atherosclerosis. This study aimed at investigating the relationship of the serum levels of alpha-tocopherol and retinol with the extent of coronary lesions in patients with coronary artery disease. Methods. Patients with coronary artery disease (n=177) aged 30–74 years, who underwent their first coronary angiography, were enrolled. The extent of coronary lesions was assessed using the Friesinger index (FI). Accordingly, patients were grouped as follows: FI = 0–4 (n=90), FI = 5–9 (n=50), and FI = 10–15 (n=37). Serum levels of vitamins were determined via high-performance liquid chromatography and serum biochemical analysis. Results. Assessment of FI-based groups revealed that 50.8% patients had a coronary artery lesion to a low extent (FI 0–4). Individuals in this group were younger and had lower glucose and serum alpha-tocopherol levels than the other groups (p<0.05). Low levels of alpha-tocopherol were more frequent in the FI 0–4 group than that in the other groups (p=0.03). No difference was observed between the mean serum retinol levels among the FI-based groups (n=0.492), and the low frequency of retinol was consistent among the FI groups (n=0.348). Conclusions. The low level of alpha-tocopherol together with the presence of dyslipidemia is probably associated with the initial events in atherosclerosis. Increased alpha-tocopherol levels in patients with more extensive coronary artery lesions may have resulted from altered vitamin E metabolism with increased oxidative stress.http://dx.doi.org/10.1155/2018/6104169 |
| spellingShingle | Carolinne Thaísa de Oliveira Fernandes Miranda Victor Hugo Rezende Duarte Marina Sampaio de Menezes Cruz Mychelle Kytchia Rodrigues Nunes Duarte Jéssica Nayara Góes de Araújo Ayda Maria Quirino Silva dos Santos Juliana Marinho de Oliveira Maria Sanali Moura Oliveira Paiva Adriana Augusto Rezende Mario Hiroyuki Hirata Rosario Dominguez Crespo Hirata Karla Danielly da Silva Ribeiro André Ducati Luchessi Vivian Nogueira Silbiger Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease Journal of Nutrition and Metabolism |
| title | Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease |
| title_full | Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease |
| title_fullStr | Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease |
| title_full_unstemmed | Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease |
| title_short | Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease |
| title_sort | association of serum alpha tocopherol and retinol with the extent of coronary lesions in coronary artery disease |
| url | http://dx.doi.org/10.1155/2018/6104169 |
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