Pheochromocytomas and paragangliomas in North African population: a single-tertiary center experience
Introduction: Pheochromocytomas (PCC) and Paragangliomas (PGL) are rare endocrine tumors. This study aimed to describe our experience with these two entities in a particular population. Methods: We identified patients with positive histopathological confirmations of PCC and PGL who were treated at a...
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Via Medica
2025-05-01
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| Series: | Arterial Hypertension |
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| Online Access: | https://journals.viamedica.pl/arterial_hypertension/article/view/100977 |
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| author | Imane Rami Fatim Zahra Bentebbaa Imane Assarrar Rania El Amel Siham Rouf Hanane Latrech |
| author_facet | Imane Rami Fatim Zahra Bentebbaa Imane Assarrar Rania El Amel Siham Rouf Hanane Latrech |
| author_sort | Imane Rami |
| collection | DOAJ |
| description | Introduction: Pheochromocytomas (PCC) and Paragangliomas (PGL) are rare endocrine tumors. This study aimed to describe our experience with these two entities in a particular population. Methods: We identified patients with positive histopathological confirmations of PCC and PGL who were treated at a tertiary center hospital between 2014 and 2023. The results were analyzed for clinical presentations, treatment, and long-term outcomes. Results: A total of 35 cases (30 PCC, 5 PGL) were identified over 9 years. The mean age of our patients was 47 ±18.1 years with a M/F sex ratio of 0.6. Blood hypertension was present in 58.8% of cases and diabetes in 47% of cases. In 35.3% of the patients, PCC was discovered during the investigation of an adrenal incidentaloma, 8.8% in the context of hereditary diseases, and 55.9% following symptoms. All patients had high levels of urinary or plasma metanephrines. Imaging was performed in all patients revealing a unilateral tumor in 90% of cases and bilateral tumors in 10%. At the postoperative follow-up, all hypertensive patients achieved good blood pressure control, resulting in a reduction in antihypertensive treatment. In addition, glycemic control improved significantly in the remaining cases. Long-term follow-up included 3 deaths, only one recurrence, and no metastases with a mean follow-up of 4.6 ±1.3 years. Conclusion: The present study confirms that the clinical presentation of pheochromocytoma is variable and non-specific. Usually, the tumor is discovered incidentally. Although pheochromocytoma is a rare tumor, appropriate evaluation, preoperative preparation, genetic testing and complete surgical resection are crucial for its management |
| format | Article |
| id | doaj-art-6b2d9d2e80f04fc191d48bf697b4d554 |
| institution | Kabale University |
| issn | 2449-6170 2449-6162 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Arterial Hypertension |
| spelling | doaj-art-6b2d9d2e80f04fc191d48bf697b4d5542025-08-21T06:08:35ZengVia MedicaArterial Hypertension2449-61702449-61622025-05-0129Continuous Publishing10.5603/ah.100977Pheochromocytomas and paragangliomas in North African population: a single-tertiary center experienceImane Rami0Fatim Zahra Bentebbaa1Imane Assarrar2Rania El Amel3Siham Rouf4Hanane Latrech5Department of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed 1st, Oujda, MoroccoDepartment of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed 1st, Oujda, MoroccoDepartment of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed 1st, Oujda, MoroccoDepartment of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed 1st, Oujda, MoroccoDepartment of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed 1st, Oujda, MoroccoDepartment of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed 1st, Oujda, MoroccoIntroduction: Pheochromocytomas (PCC) and Paragangliomas (PGL) are rare endocrine tumors. This study aimed to describe our experience with these two entities in a particular population. Methods: We identified patients with positive histopathological confirmations of PCC and PGL who were treated at a tertiary center hospital between 2014 and 2023. The results were analyzed for clinical presentations, treatment, and long-term outcomes. Results: A total of 35 cases (30 PCC, 5 PGL) were identified over 9 years. The mean age of our patients was 47 ±18.1 years with a M/F sex ratio of 0.6. Blood hypertension was present in 58.8% of cases and diabetes in 47% of cases. In 35.3% of the patients, PCC was discovered during the investigation of an adrenal incidentaloma, 8.8% in the context of hereditary diseases, and 55.9% following symptoms. All patients had high levels of urinary or plasma metanephrines. Imaging was performed in all patients revealing a unilateral tumor in 90% of cases and bilateral tumors in 10%. At the postoperative follow-up, all hypertensive patients achieved good blood pressure control, resulting in a reduction in antihypertensive treatment. In addition, glycemic control improved significantly in the remaining cases. Long-term follow-up included 3 deaths, only one recurrence, and no metastases with a mean follow-up of 4.6 ±1.3 years. Conclusion: The present study confirms that the clinical presentation of pheochromocytoma is variable and non-specific. Usually, the tumor is discovered incidentally. Although pheochromocytoma is a rare tumor, appropriate evaluation, preoperative preparation, genetic testing and complete surgical resection are crucial for its managementhttps://journals.viamedica.pl/arterial_hypertension/article/view/100977adrenal incidentalomaparagangliomapheochromocytomaneuroendocrine tumorcatecholamines |
| spellingShingle | Imane Rami Fatim Zahra Bentebbaa Imane Assarrar Rania El Amel Siham Rouf Hanane Latrech Pheochromocytomas and paragangliomas in North African population: a single-tertiary center experience Arterial Hypertension adrenal incidentaloma paraganglioma pheochromocytoma neuroendocrine tumor catecholamines |
| title | Pheochromocytomas and paragangliomas in North African population: a single-tertiary center experience |
| title_full | Pheochromocytomas and paragangliomas in North African population: a single-tertiary center experience |
| title_fullStr | Pheochromocytomas and paragangliomas in North African population: a single-tertiary center experience |
| title_full_unstemmed | Pheochromocytomas and paragangliomas in North African population: a single-tertiary center experience |
| title_short | Pheochromocytomas and paragangliomas in North African population: a single-tertiary center experience |
| title_sort | pheochromocytomas and paragangliomas in north african population a single tertiary center experience |
| topic | adrenal incidentaloma paraganglioma pheochromocytoma neuroendocrine tumor catecholamines |
| url | https://journals.viamedica.pl/arterial_hypertension/article/view/100977 |
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