Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type
While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenv...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.4061/2011/954275 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | While spleen and other secondary tissue sites
contribute to hematopoiesis, the nature of cells
produced and the environment under which this happens
are not fully defined. Evidence is reviewed here for
hematopoiesis occurring in the spleen microenvironment
leading to the production of tissue-specific antigen
presenting cells. The novel dendritic-like cell
identified in spleen is phenotypically and
functionally distinct from other described antigen
presenting cells. In order to identify these cells as
distinct, it has been necessary to show that their
lineage origin and progenitors differ from that of
other known dendritic and myeloid cell types. The
spleen therefore represents a distinct
microenvironment for hematopoiesis of a novel myeloid
cell arising from self-renewing hematopoietic stem
cells (HSC) or progenitors endogenous to spleen. |
|---|---|
| ISSN: | 1687-966X 1687-9678 |