Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI

Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI

Objectives: Susceptibility source-separation (χ-separation) MRI provides in-vivo proxy of myelin (diamagnetic susceptibility, χdia) and iron concentrations (paramagnetic susceptibility, χpara) in the central nervous system, potentially uncovering myelin- and iron-related pathology in multiple sclero...

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Main Authors: Hyeong-Geol Shin, Woojun Kim, Jung Hwan Lee, Hyun-soo Lee, Yoonho Nam, Jiwoong Kim, Xu Li, Peter C.M. van Zijl, Peter A. Calabresi, Jongho Lee, Jinhee Jang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:NeuroImage: Clinical
Subjects:
MRI
Hyper-paramagnetic sign
Iron deposition
Remyelination
Susceptibility source separation
Multiple sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S221315822500018X
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