Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI
Objectives: Susceptibility source-separation (χ-separation) MRI provides in-vivo proxy of myelin (diamagnetic susceptibility, χdia) and iron concentrations (paramagnetic susceptibility, χpara) in the central nervous system, potentially uncovering myelin- and iron-related pathology in multiple sclero...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221315822500018X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832540395337154560 |
|---|---|
| author | Hyeong-Geol Shin Woojun Kim Jung Hwan Lee Hyun-soo Lee Yoonho Nam Jiwoong Kim Xu Li Peter C.M. van Zijl Peter A. Calabresi Jongho Lee Jinhee Jang |
| author_facet | Hyeong-Geol Shin Woojun Kim Jung Hwan Lee Hyun-soo Lee Yoonho Nam Jiwoong Kim Xu Li Peter C.M. van Zijl Peter A. Calabresi Jongho Lee Jinhee Jang |
| author_sort | Hyeong-Geol Shin |
| collection | DOAJ |
| description | Objectives: Susceptibility source-separation (χ-separation) MRI provides in-vivo proxy of myelin (diamagnetic susceptibility, χdia) and iron concentrations (paramagnetic susceptibility, χpara) in the central nervous system, potentially uncovering myelin- and iron-related pathology in multiple sclerosis (MS) lesions (e.g., demyelination, remyelination, and iron-laden microglia/macrophages formation). This study aims to monitor longitudinal changes in χpara and χdia signals within MS lesions using χ-separation and evaluate the association between lesional iron and remyelination capability. Methods: Fifty participants with MS (pwMS) were followed annually over a mean period of 3.3 years (SD = 1.8 years) with MRI, including χ-separation, and clinical assessments. To monitor lesions from their early stage (lesion age < 1 year), we identified newly-noted lesions (NNLs) and contrast-enhancing lesions (CELs), and tracked their longitudinal changes in χpara and χdia signals. Results: Twenty-three pwMS were detected with NNLs and/or CELs (38 NNLs, 31 CELs;7 overlapped). Among these lesions (62 lesions in total), 27 exhibited χpara hyperintensity, termed hyper-paramagnetic sign (HPS), indicating iron deposition “throughout” the lesion (not confined to rim sign). Early-stage HPS correlated with future remyelination failure detected by χdia myelin signals (P < 0.001). After adjustment, lesions with early HPS demonstrated an annual loss in myelin signal (−1.94 ppb/year), whereas those without early HPS exhibited annual recovery (+0.66 ppb/year). Participants with confirmed disability improvement (CDI) had fewer HPS-positive lesions at baseline than those without CDI (P < 0.001). Conclusion: The presence of HPS is associated with impaired remyelination capacity and a lack of disease improvement in pwMS. Identifying HPS may help demarcate lesions more amenable to myelin repair therapies. |
| format | Article |
| id | doaj-art-6b180ce22a69416f8fa03a0bb3f1c9d6 |
| institution | Kabale University |
| issn | 2213-1582 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj-art-6b180ce22a69416f8fa03a0bb3f1c9d62025-02-05T04:31:59ZengElsevierNeuroImage: Clinical2213-15822025-01-0145103748Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRIHyeong-Geol Shin0Woojun Kim1Jung Hwan Lee2Hyun-soo Lee3Yoonho Nam4Jiwoong Kim5Xu Li6Peter C.M. van Zijl7Peter A. Calabresi8Jongho Lee9Jinhee Jang10Department of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD 21205, United StatesDepartment of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaMR Research Collaboration, Siemens Healthineers, Seoul 06620, Republic of KoreaDivision of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin 17035, South KoreaDepartment of Mathematics and Statistics, University of South Florida, Tampa, FL 33620, United StatesDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD 21205, United StatesDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD 21205, United StatesDepartment of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21218, United StatesDepartment of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Republic of KoreaDepartment of Radiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute for Precision Health, University of California, Irvine, Irvine, CA 92697, United States; Corresponding author at: Department of Radiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seochogu, 06591 Seoul, Korea.Objectives: Susceptibility source-separation (χ-separation) MRI provides in-vivo proxy of myelin (diamagnetic susceptibility, χdia) and iron concentrations (paramagnetic susceptibility, χpara) in the central nervous system, potentially uncovering myelin- and iron-related pathology in multiple sclerosis (MS) lesions (e.g., demyelination, remyelination, and iron-laden microglia/macrophages formation). This study aims to monitor longitudinal changes in χpara and χdia signals within MS lesions using χ-separation and evaluate the association between lesional iron and remyelination capability. Methods: Fifty participants with MS (pwMS) were followed annually over a mean period of 3.3 years (SD = 1.8 years) with MRI, including χ-separation, and clinical assessments. To monitor lesions from their early stage (lesion age < 1 year), we identified newly-noted lesions (NNLs) and contrast-enhancing lesions (CELs), and tracked their longitudinal changes in χpara and χdia signals. Results: Twenty-three pwMS were detected with NNLs and/or CELs (38 NNLs, 31 CELs;7 overlapped). Among these lesions (62 lesions in total), 27 exhibited χpara hyperintensity, termed hyper-paramagnetic sign (HPS), indicating iron deposition “throughout” the lesion (not confined to rim sign). Early-stage HPS correlated with future remyelination failure detected by χdia myelin signals (P < 0.001). After adjustment, lesions with early HPS demonstrated an annual loss in myelin signal (−1.94 ppb/year), whereas those without early HPS exhibited annual recovery (+0.66 ppb/year). Participants with confirmed disability improvement (CDI) had fewer HPS-positive lesions at baseline than those without CDI (P < 0.001). Conclusion: The presence of HPS is associated with impaired remyelination capacity and a lack of disease improvement in pwMS. Identifying HPS may help demarcate lesions more amenable to myelin repair therapies.http://www.sciencedirect.com/science/article/pii/S221315822500018XMRIHyper-paramagnetic signIron depositionRemyelinationSusceptibility source separationMultiple sclerosis |
| spellingShingle | Hyeong-Geol Shin Woojun Kim Jung Hwan Lee Hyun-soo Lee Yoonho Nam Jiwoong Kim Xu Li Peter C.M. van Zijl Peter A. Calabresi Jongho Lee Jinhee Jang Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI NeuroImage: Clinical MRI Hyper-paramagnetic sign Iron deposition Remyelination Susceptibility source separation Multiple sclerosis |
| title | Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI |
| title_full | Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI |
| title_fullStr | Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI |
| title_full_unstemmed | Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI |
| title_short | Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI |
| title_sort | association of iron deposition in ms lesion with remyelination capacity using susceptibility source separation mri |
| topic | MRI Hyper-paramagnetic sign Iron deposition Remyelination Susceptibility source separation Multiple sclerosis |
| url | http://www.sciencedirect.com/science/article/pii/S221315822500018X |
| work_keys_str_mv | AT hyeonggeolshin associationofirondepositioninmslesionwithremyelinationcapacityusingsusceptibilitysourceseparationmri AT woojunkim associationofirondepositioninmslesionwithremyelinationcapacityusingsusceptibilitysourceseparationmri AT junghwanlee associationofirondepositioninmslesionwithremyelinationcapacityusingsusceptibilitysourceseparationmri AT hyunsoolee associationofirondepositioninmslesionwithremyelinationcapacityusingsusceptibilitysourceseparationmri AT yoonhonam associationofirondepositioninmslesionwithremyelinationcapacityusingsusceptibilitysourceseparationmri AT jiwoongkim associationofirondepositioninmslesionwithremyelinationcapacityusingsusceptibilitysourceseparationmri AT xuli associationofirondepositioninmslesionwithremyelinationcapacityusingsusceptibilitysourceseparationmri AT petercmvanzijl associationofirondepositioninmslesionwithremyelinationcapacityusingsusceptibilitysourceseparationmri AT peteracalabresi associationofirondepositioninmslesionwithremyelinationcapacityusingsusceptibilitysourceseparationmri AT jongholee associationofirondepositioninmslesionwithremyelinationcapacityusingsusceptibilitysourceseparationmri AT jinheejang associationofirondepositioninmslesionwithremyelinationcapacityusingsusceptibilitysourceseparationmri |