Cardiorenal Syndromes and Sepsis
The cardiorenal syndrome is a clinical and pathophysiological entity defined as the concomitant presence of renal and cardiovascular dysfunction. In patients with severe sepsis and septic shock, acute cardiovascular, and renal derangements are common, that is, the septic cardiorenal syndrome. The ai...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/652967 |
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| author | C. Chelazzi G. Villa A. R. De Gaudio |
| author_facet | C. Chelazzi G. Villa A. R. De Gaudio |
| author_sort | C. Chelazzi |
| collection | DOAJ |
| description | The cardiorenal syndrome is a clinical and pathophysiological entity defined as the concomitant presence of renal and cardiovascular dysfunction. In patients with severe sepsis and septic shock, acute cardiovascular, and renal derangements are common, that is, the septic cardiorenal syndrome. The aim of this paper is to describe the pathophysiology and clinical features of septic cardiorenal syndrome in light of the actual clinical and experimental evidence. In particular, the importance of systemic and intrarenal endothelial dysfunction, alterations of kidney perfusion, and myocardial function, organ “crosstalk” and ubiquitous inflammatory injury have been extensively reviewed in light of their role in cardiorenal syndrome etiology. Treatment includes early and targeted optimization of hemodynamics to reverse systemic hypotension and restore urinary output. In case of persistent renal impairment, renal replacement therapy may be used to remove cytokines and restore renal function. |
| format | Article |
| id | doaj-art-6b16689c086946aebc33e777be67c2f4 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-6b16689c086946aebc33e777be67c2f42025-02-03T01:12:55ZengWileyInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/652967652967Cardiorenal Syndromes and SepsisC. Chelazzi0G. Villa1A. R. De Gaudio2Section of Anesthesiology and Intensive Care, Department of Critical Care, University of Florence, Padiglione Cliniche Chirurgiche, Viale Morgagni 85, 50134 Florence, ItalySection of Anesthesiology and Intensive Care, Department of Critical Care, University of Florence, Padiglione Cliniche Chirurgiche, Viale Morgagni 85, 50134 Florence, ItalySection of Anesthesiology and Intensive Care, Department of Critical Care, University of Florence, Padiglione Cliniche Chirurgiche, Viale Morgagni 85, 50134 Florence, ItalyThe cardiorenal syndrome is a clinical and pathophysiological entity defined as the concomitant presence of renal and cardiovascular dysfunction. In patients with severe sepsis and septic shock, acute cardiovascular, and renal derangements are common, that is, the septic cardiorenal syndrome. The aim of this paper is to describe the pathophysiology and clinical features of septic cardiorenal syndrome in light of the actual clinical and experimental evidence. In particular, the importance of systemic and intrarenal endothelial dysfunction, alterations of kidney perfusion, and myocardial function, organ “crosstalk” and ubiquitous inflammatory injury have been extensively reviewed in light of their role in cardiorenal syndrome etiology. Treatment includes early and targeted optimization of hemodynamics to reverse systemic hypotension and restore urinary output. In case of persistent renal impairment, renal replacement therapy may be used to remove cytokines and restore renal function.http://dx.doi.org/10.4061/2011/652967 |
| spellingShingle | C. Chelazzi G. Villa A. R. De Gaudio Cardiorenal Syndromes and Sepsis International Journal of Nephrology |
| title | Cardiorenal Syndromes and Sepsis |
| title_full | Cardiorenal Syndromes and Sepsis |
| title_fullStr | Cardiorenal Syndromes and Sepsis |
| title_full_unstemmed | Cardiorenal Syndromes and Sepsis |
| title_short | Cardiorenal Syndromes and Sepsis |
| title_sort | cardiorenal syndromes and sepsis |
| url | http://dx.doi.org/10.4061/2011/652967 |
| work_keys_str_mv | AT cchelazzi cardiorenalsyndromesandsepsis AT gvilla cardiorenalsyndromesandsepsis AT ardegaudio cardiorenalsyndromesandsepsis |