Age-specific abnormal glucose metabolism in HIV-positive people on antiviral therapy in China: a multicenter case-control study
Background Update, the link between HIV infection and abnormal glucose metabolism (AGM) is still unclear. This study aims to investigate the impact of HIV infection on AGM, including insulin resistance (IR), impaired fasting glucose (IFG), and diabetes mellitus (DM).Methods A multicenter case-contro...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2024.2427910 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591167479349248 |
|---|---|
| author | Lijun Xu Mengsha Chen Chunhui Yan Xiaofeng Li Xiaoli Ni Minghang Zhou Weiwei Xu Junfang Xu Shigui Yang |
| author_facet | Lijun Xu Mengsha Chen Chunhui Yan Xiaofeng Li Xiaoli Ni Minghang Zhou Weiwei Xu Junfang Xu Shigui Yang |
| author_sort | Lijun Xu |
| collection | DOAJ |
| description | Background Update, the link between HIV infection and abnormal glucose metabolism (AGM) is still unclear. This study aims to investigate the impact of HIV infection on AGM, including insulin resistance (IR), impaired fasting glucose (IFG), and diabetes mellitus (DM).Methods A multicenter case-control study was conducted in Zhejiang province, China. After matching, the study included 1030 people living with HIV (PLWH) and 1030 people living without HIV (PLWTH). The age-specific incidence of AGM was compared between the two groups. Poisson regression models were used to calculate the relative risk (RR) and its 95% confidence interval (CI) to assess the associations.Results Compared to PLWTH, PLWH had a higher rate of IR, IFG and DM, and a higher risk of developing IR (RR: 1.83; 95% CI: 1.60–2.10), IFG (RR: 3.87; 95% CI: 2.55–6.07), and DM (RR: 1.52; 95% CI: 1.09–2.12). In the 30–44 age group, the risk of IR, IFG, and DM was the highest, with RRs of 2.04 (95%CI: 1.69–2.48), 7.46 (95%CI: 2.91–25.27), and 1.88 (95%CI: 0.90–4.10). HIV acquisition and cART usage >5 years were associated with increased risks of DM.Conclusion HIV infection is associated with early onset and high prevalence of IR and IFG. Longer duration of HIV infection and cART usage increased the occurrence of DM. These findings contribute to a better understanding of age-specific AGM and the modified glucose monitor strategies in PLWH. |
| format | Article |
| id | doaj-art-6b125e40e9e54cb3b0f433acb031fb1d |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-6b125e40e9e54cb3b0f433acb031fb1d2025-01-22T16:46:35ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2024.2427910Age-specific abnormal glucose metabolism in HIV-positive people on antiviral therapy in China: a multicenter case-control studyLijun Xu0Mengsha Chen1Chunhui Yan2Xiaofeng Li3Xiaoli Ni4Minghang Zhou5Weiwei Xu6Junfang Xu7Shigui Yang8National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Infectious Diseases, The First Hospital of Linping District, Hangzhou, ChinaDepartment of Infectious Diseases, Huzhou Central Hospital of Zhejiang University, Huzhou, ChinaDepartment of Infectious Diseases, Yongkang First People’s Hospital, Jinhua, ChinaNational Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Endocrinology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaBackground Update, the link between HIV infection and abnormal glucose metabolism (AGM) is still unclear. This study aims to investigate the impact of HIV infection on AGM, including insulin resistance (IR), impaired fasting glucose (IFG), and diabetes mellitus (DM).Methods A multicenter case-control study was conducted in Zhejiang province, China. After matching, the study included 1030 people living with HIV (PLWH) and 1030 people living without HIV (PLWTH). The age-specific incidence of AGM was compared between the two groups. Poisson regression models were used to calculate the relative risk (RR) and its 95% confidence interval (CI) to assess the associations.Results Compared to PLWTH, PLWH had a higher rate of IR, IFG and DM, and a higher risk of developing IR (RR: 1.83; 95% CI: 1.60–2.10), IFG (RR: 3.87; 95% CI: 2.55–6.07), and DM (RR: 1.52; 95% CI: 1.09–2.12). In the 30–44 age group, the risk of IR, IFG, and DM was the highest, with RRs of 2.04 (95%CI: 1.69–2.48), 7.46 (95%CI: 2.91–25.27), and 1.88 (95%CI: 0.90–4.10). HIV acquisition and cART usage >5 years were associated with increased risks of DM.Conclusion HIV infection is associated with early onset and high prevalence of IR and IFG. Longer duration of HIV infection and cART usage increased the occurrence of DM. These findings contribute to a better understanding of age-specific AGM and the modified glucose monitor strategies in PLWH.https://www.tandfonline.com/doi/10.1080/07853890.2024.2427910HIVAIDSabnormal glucose metabolisminsulin resistanceimpaired fasting glucosediabetes mellitus |
| spellingShingle | Lijun Xu Mengsha Chen Chunhui Yan Xiaofeng Li Xiaoli Ni Minghang Zhou Weiwei Xu Junfang Xu Shigui Yang Age-specific abnormal glucose metabolism in HIV-positive people on antiviral therapy in China: a multicenter case-control study Annals of Medicine HIV AIDS abnormal glucose metabolism insulin resistance impaired fasting glucose diabetes mellitus |
| title | Age-specific abnormal glucose metabolism in HIV-positive people on antiviral therapy in China: a multicenter case-control study |
| title_full | Age-specific abnormal glucose metabolism in HIV-positive people on antiviral therapy in China: a multicenter case-control study |
| title_fullStr | Age-specific abnormal glucose metabolism in HIV-positive people on antiviral therapy in China: a multicenter case-control study |
| title_full_unstemmed | Age-specific abnormal glucose metabolism in HIV-positive people on antiviral therapy in China: a multicenter case-control study |
| title_short | Age-specific abnormal glucose metabolism in HIV-positive people on antiviral therapy in China: a multicenter case-control study |
| title_sort | age specific abnormal glucose metabolism in hiv positive people on antiviral therapy in china a multicenter case control study |
| topic | HIV AIDS abnormal glucose metabolism insulin resistance impaired fasting glucose diabetes mellitus |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2024.2427910 |
| work_keys_str_mv | AT lijunxu agespecificabnormalglucosemetabolisminhivpositivepeopleonantiviraltherapyinchinaamulticentercasecontrolstudy AT mengshachen agespecificabnormalglucosemetabolisminhivpositivepeopleonantiviraltherapyinchinaamulticentercasecontrolstudy AT chunhuiyan agespecificabnormalglucosemetabolisminhivpositivepeopleonantiviraltherapyinchinaamulticentercasecontrolstudy AT xiaofengli agespecificabnormalglucosemetabolisminhivpositivepeopleonantiviraltherapyinchinaamulticentercasecontrolstudy AT xiaolini agespecificabnormalglucosemetabolisminhivpositivepeopleonantiviraltherapyinchinaamulticentercasecontrolstudy AT minghangzhou agespecificabnormalglucosemetabolisminhivpositivepeopleonantiviraltherapyinchinaamulticentercasecontrolstudy AT weiweixu agespecificabnormalglucosemetabolisminhivpositivepeopleonantiviraltherapyinchinaamulticentercasecontrolstudy AT junfangxu agespecificabnormalglucosemetabolisminhivpositivepeopleonantiviraltherapyinchinaamulticentercasecontrolstudy AT shiguiyang agespecificabnormalglucosemetabolisminhivpositivepeopleonantiviraltherapyinchinaamulticentercasecontrolstudy |