CASE REPORT ON TWO CONSECUTIVE PATIENTS WITH NEUROINVASIVE WEST NILE VIRUS INFECTION IN AN INTENSIVE CARE UNIT
We present the clinical course, and treatment of two consecutive cases of neuroinvasive West Nile virus (WNV) infection in the Clinic of Intensive Care, an Intensive Care Unit (ICU) at the Military Medical Academy - Sofia. Clinical and epidemiological data, microbiological, laboratory, molecular me...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
National Center of Infectious and Parasitic Diseases
2025-01-01
|
| Series: | Problems of Infectious and Parasitic Diseases |
| Subjects: | |
| Online Access: | https://pipd.ncipd.org/index.php/pipd/article/view/146 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832595473206083584 |
|---|---|
| author | Silviya Stoyanova Raynichka Mihaylova-Garnizova Emilia Naseva Severina Dakova Iva Christova Konstantin Ramshev |
| author_facet | Silviya Stoyanova Raynichka Mihaylova-Garnizova Emilia Naseva Severina Dakova Iva Christova Konstantin Ramshev |
| author_sort | Silviya Stoyanova |
| collection | DOAJ |
| description |
We present the clinical course, and treatment of two consecutive cases of neuroinvasive West Nile virus (WNV) infection in the Clinic of Intensive Care, an Intensive Care Unit (ICU) at the Military Medical Academy - Sofia. Clinical and epidemiological data, microbiological, laboratory, molecular methods, and imaging techniques were used. Both patients resided in Sofia, Bulgaria, and had not travelled in recent months. The first case was a 60-year-old man who have had mental status changes, fever, and progression of existing Parkinson's disease. Antibodies to WNV were present in cerebrospinal fluid (CSF). His condition worsened with the development of sepsis and respiratory failure and he ended up lethally. The second case was a 72-year-old man who had fever and lower dyspeptic syndrome for one week, mental status changes, with adynamia to inability to walk independently, and head, hand and tongue tremors. CSF analysis showed mild pleocytosis with proteinorachy. Antibodies to WNV were present in serum, and PCR for WNV in urine was positive. The patient was admitted to ICU due to worsened mental and neurological status, coma and development of acute respiratory failure, necessitating intubation and assisted pulmonary ventilation. The patient ended lethally 13 days later. Neuroinvasive WNV infection can cause substantial morbidity, particularly among older adults, and high mortality, in the presence of comorbidities. Physicians should include West Nile virus infection in the differential diagnosis of aseptic meningitis and encephalitis, should perform appropriate laboratory tests, and report immediately the cases to the public health authorities.
|
| format | Article |
| id | doaj-art-6b069a95bb9d40e1bb7cec0aab5ac243 |
| institution | Kabale University |
| issn | 0204-9155 2815-2808 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | National Center of Infectious and Parasitic Diseases |
| record_format | Article |
| series | Problems of Infectious and Parasitic Diseases |
| spelling | doaj-art-6b069a95bb9d40e1bb7cec0aab5ac2432025-01-18T19:01:04ZengNational Center of Infectious and Parasitic DiseasesProblems of Infectious and Parasitic Diseases0204-91552815-28082025-01-0152310.58395/x3z0jw80CASE REPORT ON TWO CONSECUTIVE PATIENTS WITH NEUROINVASIVE WEST NILE VIRUS INFECTION IN AN INTENSIVE CARE UNITSilviya Stoyanova0Raynichka Mihaylova-Garnizova1Emilia Naseva2Severina Dakova3Iva Christova4Konstantin Ramshev5Clinic of Intensive Care, Military Medical Academy – Sofia, BulgariaClinic of Infectious Diseases, Military Medical Academy – Sofia, BulgariaDepartment of Health Management and Health Economics, Faculty of Public Health "Prof. Tsekomir Vodenicharov, MD, DSc", Medical University of Sofia, BulgariaClinic of Intensive Care, Military Medical Academy – Sofia, BulgariaDepartment of Microbiology, National Center of Infectious and Parasitic Diseases, Sofia, BulgariaClinic of Intensive Care, Military Medical Academy – Sofia, Bulgaria We present the clinical course, and treatment of two consecutive cases of neuroinvasive West Nile virus (WNV) infection in the Clinic of Intensive Care, an Intensive Care Unit (ICU) at the Military Medical Academy - Sofia. Clinical and epidemiological data, microbiological, laboratory, molecular methods, and imaging techniques were used. Both patients resided in Sofia, Bulgaria, and had not travelled in recent months. The first case was a 60-year-old man who have had mental status changes, fever, and progression of existing Parkinson's disease. Antibodies to WNV were present in cerebrospinal fluid (CSF). His condition worsened with the development of sepsis and respiratory failure and he ended up lethally. The second case was a 72-year-old man who had fever and lower dyspeptic syndrome for one week, mental status changes, with adynamia to inability to walk independently, and head, hand and tongue tremors. CSF analysis showed mild pleocytosis with proteinorachy. Antibodies to WNV were present in serum, and PCR for WNV in urine was positive. The patient was admitted to ICU due to worsened mental and neurological status, coma and development of acute respiratory failure, necessitating intubation and assisted pulmonary ventilation. The patient ended lethally 13 days later. Neuroinvasive WNV infection can cause substantial morbidity, particularly among older adults, and high mortality, in the presence of comorbidities. Physicians should include West Nile virus infection in the differential diagnosis of aseptic meningitis and encephalitis, should perform appropriate laboratory tests, and report immediately the cases to the public health authorities. https://pipd.ncipd.org/index.php/pipd/article/view/146West Nile Virusfeverneuroinvasive diseaseencephalitis |
| spellingShingle | Silviya Stoyanova Raynichka Mihaylova-Garnizova Emilia Naseva Severina Dakova Iva Christova Konstantin Ramshev CASE REPORT ON TWO CONSECUTIVE PATIENTS WITH NEUROINVASIVE WEST NILE VIRUS INFECTION IN AN INTENSIVE CARE UNIT Problems of Infectious and Parasitic Diseases West Nile Virus fever neuroinvasive disease encephalitis |
| title | CASE REPORT ON TWO CONSECUTIVE PATIENTS WITH NEUROINVASIVE WEST NILE VIRUS INFECTION IN AN INTENSIVE CARE UNIT |
| title_full | CASE REPORT ON TWO CONSECUTIVE PATIENTS WITH NEUROINVASIVE WEST NILE VIRUS INFECTION IN AN INTENSIVE CARE UNIT |
| title_fullStr | CASE REPORT ON TWO CONSECUTIVE PATIENTS WITH NEUROINVASIVE WEST NILE VIRUS INFECTION IN AN INTENSIVE CARE UNIT |
| title_full_unstemmed | CASE REPORT ON TWO CONSECUTIVE PATIENTS WITH NEUROINVASIVE WEST NILE VIRUS INFECTION IN AN INTENSIVE CARE UNIT |
| title_short | CASE REPORT ON TWO CONSECUTIVE PATIENTS WITH NEUROINVASIVE WEST NILE VIRUS INFECTION IN AN INTENSIVE CARE UNIT |
| title_sort | case report on two consecutive patients with neuroinvasive west nile virus infection in an intensive care unit |
| topic | West Nile Virus fever neuroinvasive disease encephalitis |
| url | https://pipd.ncipd.org/index.php/pipd/article/view/146 |
| work_keys_str_mv | AT silviyastoyanova casereportontwoconsecutivepatientswithneuroinvasivewestnilevirusinfectioninanintensivecareunit AT raynichkamihaylovagarnizova casereportontwoconsecutivepatientswithneuroinvasivewestnilevirusinfectioninanintensivecareunit AT emilianaseva casereportontwoconsecutivepatientswithneuroinvasivewestnilevirusinfectioninanintensivecareunit AT severinadakova casereportontwoconsecutivepatientswithneuroinvasivewestnilevirusinfectioninanintensivecareunit AT ivachristova casereportontwoconsecutivepatientswithneuroinvasivewestnilevirusinfectioninanintensivecareunit AT konstantinramshev casereportontwoconsecutivepatientswithneuroinvasivewestnilevirusinfectioninanintensivecareunit |