A reagent to access methyl sulfones
Abstract A chemical reagent to access methyl sulfones has been developed. Its reaction with various bis-nucleophiles leads to the rapid formation of previously unknown heteroaromatic methyl sulfones. Analogous strategy can also be used to construct alkyl-, CHF2-, CF3- and even bicyclo[1.1.1]pentane-...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55027-x |
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| author | Yaroslav Poplavskyi Vasyl Ripenko Sergei Bova Angelina Biitseva Yurii V. Dmitriv Andrei A. Tolmachev Iryna V. Sadkova Iryna Pishel Oleksii Grygorov Vo Quang Huy Phan H. V. Rasika Dias Pavel K. Mykhailiuk |
| author_facet | Yaroslav Poplavskyi Vasyl Ripenko Sergei Bova Angelina Biitseva Yurii V. Dmitriv Andrei A. Tolmachev Iryna V. Sadkova Iryna Pishel Oleksii Grygorov Vo Quang Huy Phan H. V. Rasika Dias Pavel K. Mykhailiuk |
| author_sort | Yaroslav Poplavskyi |
| collection | DOAJ |
| description | Abstract A chemical reagent to access methyl sulfones has been developed. Its reaction with various bis-nucleophiles leads to the rapid formation of previously unknown heteroaromatic methyl sulfones. Analogous strategy can also be used to construct alkyl-, CHF2-, CF3- and even bicyclo[1.1.1]pentane-containing derivatives. These compounds have been demonstrated to have a high potential for use in medicinal chemistry and coordination chemistry. |
| format | Article |
| id | doaj-art-6b04371ee0584ba9a7d66cf8e217cc21 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-6b04371ee0584ba9a7d66cf8e217cc212025-02-02T12:31:22ZengNature PortfolioNature Communications2041-17232025-01-0116111010.1038/s41467-024-55027-xA reagent to access methyl sulfonesYaroslav Poplavskyi0Vasyl Ripenko1Sergei Bova2Angelina Biitseva3Yurii V. Dmitriv4Andrei A. Tolmachev5Iryna V. Sadkova6Iryna Pishel7Oleksii Grygorov8Vo Quang Huy Phan9H. V. Rasika Dias10Pavel K. Mykhailiuk11Enamine LtdEnamine LtdEnamine LtdEnamine LtdEnamine LtdEnamine LtdEnamine LtdBientaBientaDepartment of Chemistry and Biochemistry, The University of Texas at ArlingtonDepartment of Chemistry and Biochemistry, The University of Texas at ArlingtonEnamine LtdAbstract A chemical reagent to access methyl sulfones has been developed. Its reaction with various bis-nucleophiles leads to the rapid formation of previously unknown heteroaromatic methyl sulfones. Analogous strategy can also be used to construct alkyl-, CHF2-, CF3- and even bicyclo[1.1.1]pentane-containing derivatives. These compounds have been demonstrated to have a high potential for use in medicinal chemistry and coordination chemistry.https://doi.org/10.1038/s41467-024-55027-x |
| spellingShingle | Yaroslav Poplavskyi Vasyl Ripenko Sergei Bova Angelina Biitseva Yurii V. Dmitriv Andrei A. Tolmachev Iryna V. Sadkova Iryna Pishel Oleksii Grygorov Vo Quang Huy Phan H. V. Rasika Dias Pavel K. Mykhailiuk A reagent to access methyl sulfones Nature Communications |
| title | A reagent to access methyl sulfones |
| title_full | A reagent to access methyl sulfones |
| title_fullStr | A reagent to access methyl sulfones |
| title_full_unstemmed | A reagent to access methyl sulfones |
| title_short | A reagent to access methyl sulfones |
| title_sort | reagent to access methyl sulfones |
| url | https://doi.org/10.1038/s41467-024-55027-x |
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