Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature
Background. Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) is an intermediate or locally aggressive form of adipocytic soft tissue sarcoma. Muscular dystrophy (MD) is characterized by progressive muscle atrophy and its replacement by adipose and fibrous tissue. Recently, some a...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Case Reports in Orthopedics |
| Online Access: | http://dx.doi.org/10.1155/2017/3025084 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559004336783360 |
|---|---|
| author | Ryo Miyagi Toshihiko Nishisho Shinjiro Takata Yoshimitsu Shimatani Shunichi Toki Koichi Sairyo |
| author_facet | Ryo Miyagi Toshihiko Nishisho Shinjiro Takata Yoshimitsu Shimatani Shunichi Toki Koichi Sairyo |
| author_sort | Ryo Miyagi |
| collection | DOAJ |
| description | Background. Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) is an intermediate or locally aggressive form of adipocytic soft tissue sarcoma. Muscular dystrophy (MD) is characterized by progressive muscle atrophy and its replacement by adipose and fibrous tissue. Recently, some authors have reported that MD genes are related to neoplastic formation, but there have been no detailed clinical reports of ALT associated with MD. Case Presentation. A 73-year-old woman with a diagnosis of limb-girdle MD visited our department for recurrence of a huge tumor in her left thigh. She had undergone resection of a lipoma at the same site more than 20 years earlier. Imaging studies revealed a lipomatous tumor in her left thigh. We performed marginal resection including the adjacent muscles. Histological diagnosis was atypical lipomatous tumor. The postoperative course was uneventful, with no recurrence at 36 months of follow-up. Conclusion. We encountered a huge atypical tumor in a patient with MD. This is the first detailed report to describe an association between ALT and MD. We hypothesize that degenerative changes occurring in adipose tissue during muscle atrophy can cause lipomatous neoplasms and moreover that the mutation of MD-related genes may lead to the proliferation of tumor cells or to malignancy. |
| format | Article |
| id | doaj-art-6ae5b16b870f4bcf99ef0977413e9df7 |
| institution | Kabale University |
| issn | 2090-6749 2090-6757 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Orthopedics |
| spelling | doaj-art-6ae5b16b870f4bcf99ef0977413e9df72025-02-03T01:31:06ZengWileyCase Reports in Orthopedics2090-67492090-67572017-01-01201710.1155/2017/30250843025084Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the LiteratureRyo Miyagi0Toshihiko Nishisho1Shinjiro Takata2Yoshimitsu Shimatani3Shunichi Toki4Koichi Sairyo5Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, JapanDepartment of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, JapanDepartment of Orthopedics, National Hospital Organization Tokushima Hospital, Tokushima, JapanDepartment of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, JapanDepartment of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, JapanDepartment of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, JapanBackground. Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) is an intermediate or locally aggressive form of adipocytic soft tissue sarcoma. Muscular dystrophy (MD) is characterized by progressive muscle atrophy and its replacement by adipose and fibrous tissue. Recently, some authors have reported that MD genes are related to neoplastic formation, but there have been no detailed clinical reports of ALT associated with MD. Case Presentation. A 73-year-old woman with a diagnosis of limb-girdle MD visited our department for recurrence of a huge tumor in her left thigh. She had undergone resection of a lipoma at the same site more than 20 years earlier. Imaging studies revealed a lipomatous tumor in her left thigh. We performed marginal resection including the adjacent muscles. Histological diagnosis was atypical lipomatous tumor. The postoperative course was uneventful, with no recurrence at 36 months of follow-up. Conclusion. We encountered a huge atypical tumor in a patient with MD. This is the first detailed report to describe an association between ALT and MD. We hypothesize that degenerative changes occurring in adipose tissue during muscle atrophy can cause lipomatous neoplasms and moreover that the mutation of MD-related genes may lead to the proliferation of tumor cells or to malignancy.http://dx.doi.org/10.1155/2017/3025084 |
| spellingShingle | Ryo Miyagi Toshihiko Nishisho Shinjiro Takata Yoshimitsu Shimatani Shunichi Toki Koichi Sairyo Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature Case Reports in Orthopedics |
| title | Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature |
| title_full | Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature |
| title_fullStr | Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature |
| title_full_unstemmed | Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature |
| title_short | Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature |
| title_sort | atypical lipomatous tumor well differentiated liposarcoma developed in a patient with progressive muscular dystrophy a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2017/3025084 |
| work_keys_str_mv | AT ryomiyagi atypicallipomatoustumorwelldifferentiatedliposarcomadevelopedinapatientwithprogressivemusculardystrophyacasereportandreviewoftheliterature AT toshihikonishisho atypicallipomatoustumorwelldifferentiatedliposarcomadevelopedinapatientwithprogressivemusculardystrophyacasereportandreviewoftheliterature AT shinjirotakata atypicallipomatoustumorwelldifferentiatedliposarcomadevelopedinapatientwithprogressivemusculardystrophyacasereportandreviewoftheliterature AT yoshimitsushimatani atypicallipomatoustumorwelldifferentiatedliposarcomadevelopedinapatientwithprogressivemusculardystrophyacasereportandreviewoftheliterature AT shunichitoki atypicallipomatoustumorwelldifferentiatedliposarcomadevelopedinapatientwithprogressivemusculardystrophyacasereportandreviewoftheliterature AT koichisairyo atypicallipomatoustumorwelldifferentiatedliposarcomadevelopedinapatientwithprogressivemusculardystrophyacasereportandreviewoftheliterature |