Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 Axis
The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of inter...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/909514 |
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| _version_ | 1832555924369178624 |
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| author | Linlin Chen Yiyou Zou Jie Peng Fanggen Lu Yani Yin Fujun Li Junwen Yang |
| author_facet | Linlin Chen Yiyou Zou Jie Peng Fanggen Lu Yani Yin Fujun Li Junwen Yang |
| author_sort | Linlin Chen |
| collection | DOAJ |
| description | The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin- (IL-) 17, tumor necrosis factor α (TNFα), IL-23, transforming growth factor β1 (TGFβ1), signal transducer and activator of transcription 3 (STAT3), and phosphorylated (p)-STAT3 was examined by RT-PCR, Western blotting, and immunohistochemical analysis. And the results showed that administration of L. acidophilus suppressed Th17 cell-mediated secretion of proinflammatory cytokine IL-17 through downregulation of IL-23 and TGFβ1 expression and downstream phosphorylation of p-STAT3. |
| format | Article |
| id | doaj-art-6ad7199115db47208ca883585723c4c3 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-6ad7199115db47208ca883585723c4c32025-02-03T05:46:53ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/909514909514Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 AxisLinlin Chen0Yiyou Zou1Jie Peng2Fanggen Lu3Yani Yin4Fujun Li5Junwen Yang6Department of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Gastroenterology, Second Xiangya Hospital of Central South University, Changsha 410008, ChinaDepartment of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410011, ChinaThe aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin- (IL-) 17, tumor necrosis factor α (TNFα), IL-23, transforming growth factor β1 (TGFβ1), signal transducer and activator of transcription 3 (STAT3), and phosphorylated (p)-STAT3 was examined by RT-PCR, Western blotting, and immunohistochemical analysis. And the results showed that administration of L. acidophilus suppressed Th17 cell-mediated secretion of proinflammatory cytokine IL-17 through downregulation of IL-23 and TGFβ1 expression and downstream phosphorylation of p-STAT3.http://dx.doi.org/10.1155/2015/909514 |
| spellingShingle | Linlin Chen Yiyou Zou Jie Peng Fanggen Lu Yani Yin Fujun Li Junwen Yang Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 Axis Journal of Immunology Research |
| title | Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 Axis |
| title_full | Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 Axis |
| title_fullStr | Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 Axis |
| title_full_unstemmed | Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 Axis |
| title_short | Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 Axis |
| title_sort | lactobacillus acidophilus suppresses colitis associated activation of the il 23 th17 axis |
| url | http://dx.doi.org/10.1155/2015/909514 |
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