Perinatal Cerebellar Injury in Human and Animal Models
Cerebellar injury is increasingly recognized through advanced neonatal brain imaging as a complication of premature birth. Survivors of preterm birth demonstrate a constellation of long-term neurodevelopmental deficits, many of which are potentially referable to cerebellar injury, including impaired...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/858929 |
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| _version_ | 1832558865202282496 |
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| author | Valerie Biran Catherine Verney Donna M. Ferriero |
| author_facet | Valerie Biran Catherine Verney Donna M. Ferriero |
| author_sort | Valerie Biran |
| collection | DOAJ |
| description | Cerebellar injury is increasingly recognized through advanced neonatal brain imaging as a complication of premature birth. Survivors of preterm birth demonstrate a constellation of long-term neurodevelopmental deficits, many of which are potentially referable to cerebellar injury, including impaired motor functions such as fine motor incoordination, impaired motor sequencing and also cognitive, behavioral dysfunction among older patients. This paper reviews the morphogenesis and histogenesis of the human and rodent developing cerebellum, and its more frequent injuries in preterm. Most cerebellar lesions are cerebellar hemorrhage and infarction usually leading to cerebellar abnormalities and/or atrophy, but the exact pathogenesis of lesions of the cerebellum is unknown. The different mechanisms involved have been investigated with animal models and are primarily hypoxia, ischemia, infection, and inflammation Exposure to drugs and undernutrition can also induce cerebellar abnormalities. Different models are detailed to analyze these various disturbances of cerebellar development around birth. |
| format | Article |
| id | doaj-art-6ace9316cd5c4115b6fc1340242aad9d |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-6ace9316cd5c4115b6fc1340242aad9d2025-02-03T01:31:24ZengWileyNeurology Research International2090-18522090-18602012-01-01201210.1155/2012/858929858929Perinatal Cerebellar Injury in Human and Animal ModelsValerie Biran0Catherine Verney1Donna M. Ferriero2Departments of Neurology and Pediatrics, Newborn Brain Institute, University of California San Francisco, San Francisco, CA 94143, USAU676 Inserm, Paris, FranceDepartments of Neurology and Pediatrics, Newborn Brain Institute, University of California San Francisco, San Francisco, CA 94143, USACerebellar injury is increasingly recognized through advanced neonatal brain imaging as a complication of premature birth. Survivors of preterm birth demonstrate a constellation of long-term neurodevelopmental deficits, many of which are potentially referable to cerebellar injury, including impaired motor functions such as fine motor incoordination, impaired motor sequencing and also cognitive, behavioral dysfunction among older patients. This paper reviews the morphogenesis and histogenesis of the human and rodent developing cerebellum, and its more frequent injuries in preterm. Most cerebellar lesions are cerebellar hemorrhage and infarction usually leading to cerebellar abnormalities and/or atrophy, but the exact pathogenesis of lesions of the cerebellum is unknown. The different mechanisms involved have been investigated with animal models and are primarily hypoxia, ischemia, infection, and inflammation Exposure to drugs and undernutrition can also induce cerebellar abnormalities. Different models are detailed to analyze these various disturbances of cerebellar development around birth.http://dx.doi.org/10.1155/2012/858929 |
| spellingShingle | Valerie Biran Catherine Verney Donna M. Ferriero Perinatal Cerebellar Injury in Human and Animal Models Neurology Research International |
| title | Perinatal Cerebellar Injury in Human and Animal Models |
| title_full | Perinatal Cerebellar Injury in Human and Animal Models |
| title_fullStr | Perinatal Cerebellar Injury in Human and Animal Models |
| title_full_unstemmed | Perinatal Cerebellar Injury in Human and Animal Models |
| title_short | Perinatal Cerebellar Injury in Human and Animal Models |
| title_sort | perinatal cerebellar injury in human and animal models |
| url | http://dx.doi.org/10.1155/2012/858929 |
| work_keys_str_mv | AT valeriebiran perinatalcerebellarinjuryinhumanandanimalmodels AT catherineverney perinatalcerebellarinjuryinhumanandanimalmodels AT donnamferriero perinatalcerebellarinjuryinhumanandanimalmodels |