Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis
Abstract The case of Lumbar spinal stenosis (LSS) combined with tophi due to gout is rarely reported. In the course of our clinic work, we encountered a young male patient who was diagnosed with a history of gout for 5 years and was targeted as LSS combined with gouty tophi, and we would like to sha...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-025-08273-z |
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| author | Xiao Zhang Wenbo Gu Di Luo Xi Zhu Xusheng Li Haifeng Yuan |
| author_facet | Xiao Zhang Wenbo Gu Di Luo Xi Zhu Xusheng Li Haifeng Yuan |
| author_sort | Xiao Zhang |
| collection | DOAJ |
| description | Abstract The case of Lumbar spinal stenosis (LSS) combined with tophi due to gout is rarely reported. In the course of our clinic work, we encountered a young male patient who was diagnosed with a history of gout for 5 years and was targeted as LSS combined with gouty tophi, and we would like to share this case. In addition, in order to further investigate the deep mechanism of LSS associated with gout, we obtained the intersecting genes of the two diseases based on a machine learning approach by obtaining the dataset GSE113212 related to LSS from the Gene Expression Omnibus (GEO) database, and the genes related to gout from the human gene database. We found that TGFB1, PPARG, and SAMRCC1 may be important biomarkers for treating of both diseases. From a clinical perspective, clinicians should be vigilant about the possibility of gouty lumbar spinal stenosis with tophi in young patients presenting with back pain, hyperuricemia, and elevated inflammatory markers. A combined surgical and pharmacological treatment plan has a favorable prognosis. Investigating the mechanisms of action of core genes may provide new insights for treatment, ultimately leading to the development of comprehensive and personalized diagnostic and therapeutic strategies. |
| format | Article |
| id | doaj-art-6acb1c94ef5e49c39236f89cd83bdc40 |
| institution | Kabale University |
| issn | 1471-2474 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-6acb1c94ef5e49c39236f89cd83bdc402025-01-19T12:04:28ZengBMCBMC Musculoskeletal Disorders1471-24742025-01-012611810.1186/s12891-025-08273-zTreatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysisXiao Zhang0Wenbo Gu1Di Luo2Xi Zhu3Xusheng Li4Haifeng Yuan5General Hospital of Ningxia Medical UniversityGeneral Hospital of Ningxia Medical UniversityNingxia Medical UniversityGeneral Hospital of Ningxia Medical UniversityGeneral Hospital of Ningxia Medical UniversityGeneral Hospital of Ningxia Medical UniversityAbstract The case of Lumbar spinal stenosis (LSS) combined with tophi due to gout is rarely reported. In the course of our clinic work, we encountered a young male patient who was diagnosed with a history of gout for 5 years and was targeted as LSS combined with gouty tophi, and we would like to share this case. In addition, in order to further investigate the deep mechanism of LSS associated with gout, we obtained the intersecting genes of the two diseases based on a machine learning approach by obtaining the dataset GSE113212 related to LSS from the Gene Expression Omnibus (GEO) database, and the genes related to gout from the human gene database. We found that TGFB1, PPARG, and SAMRCC1 may be important biomarkers for treating of both diseases. From a clinical perspective, clinicians should be vigilant about the possibility of gouty lumbar spinal stenosis with tophi in young patients presenting with back pain, hyperuricemia, and elevated inflammatory markers. A combined surgical and pharmacological treatment plan has a favorable prognosis. Investigating the mechanisms of action of core genes may provide new insights for treatment, ultimately leading to the development of comprehensive and personalized diagnostic and therapeutic strategies.https://doi.org/10.1186/s12891-025-08273-zLumbar spinal stenosisGoutGouty tophiData miningCase report |
| spellingShingle | Xiao Zhang Wenbo Gu Di Luo Xi Zhu Xusheng Li Haifeng Yuan Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis BMC Musculoskeletal Disorders Lumbar spinal stenosis Gout Gouty tophi Data mining Case report |
| title | Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis |
| title_full | Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis |
| title_fullStr | Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis |
| title_full_unstemmed | Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis |
| title_short | Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis |
| title_sort | treatment of gouty lumbar spinal stenosis a case report and bioinformatics analysis |
| topic | Lumbar spinal stenosis Gout Gouty tophi Data mining Case report |
| url | https://doi.org/10.1186/s12891-025-08273-z |
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