Association between Sleep Disruption and Levels of Lipids in Caucasians with Type 2 Diabetes
Aim. To investigate the association between sleep quality and duration with lipid and glycaemic control in Caucasian subjects with type 2 diabetes. Methods. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) in 114 type 2 diabetes (T2DM) subjects. Comparisons were made betwee...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/341506 |
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| author | Wan Aizad Wan Mahmood Mohd Shazli Draman Yusoff Lucy Ann Behan Andrea Di Perna Tommy Kyaw Tun John McDermott Seamus Sreenan |
| author_facet | Wan Aizad Wan Mahmood Mohd Shazli Draman Yusoff Lucy Ann Behan Andrea Di Perna Tommy Kyaw Tun John McDermott Seamus Sreenan |
| author_sort | Wan Aizad Wan Mahmood |
| collection | DOAJ |
| description | Aim. To investigate the association between sleep quality and duration with lipid and glycaemic control in Caucasian subjects with type 2 diabetes. Methods. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) in 114 type 2 diabetes (T2DM) subjects. Comparisons were made between subjects with different sleep quality and sleep duration. Hierarchical multiple regression analyses were used to determine contributors to metabolic parameters. Results.
Subjects with poor sleep quality (PQ; PSQI ≥ 6) had higher systolic blood pressure, glycated haemoglobin, urine albumin : creatinine ratio (UAC), total cholesterol (TC), and triglycerides (TG) ( for all) compared to those with good sleep quality (GQ; PSQI ≤ 5). Long sleep duration (LSD) subjects had higher TC and short sleep duration (SSD) subjects had higher TG compared to those with medium sleep duration. Sleep duration and PSQI score were independent predictors of TC and low-density lipoprotein cholesterol (LDL), contributing to 14.0% and 6.1% of the total variance, respectively.
Conclusions. In this Caucasian T2DM population, PQ is associated with adverse cardiovascular risk markers, and long and short sleep disruptions have an independent negative impact on lipids. Sleep assessment should be included as part of a diabetes clinic review. |
| format | Article |
| id | doaj-art-6ac8bf3aeb34490599c4489d996f4dc4 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6ac8bf3aeb34490599c4489d996f4dc42025-02-03T01:12:19ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/341506341506Association between Sleep Disruption and Levels of Lipids in Caucasians with Type 2 DiabetesWan Aizad Wan Mahmood0Mohd Shazli Draman Yusoff1Lucy Ann Behan2Andrea Di Perna3Tommy Kyaw Tun4John McDermott5Seamus Sreenan6Department of Endocrinology and Diabetes, Royal College of Surgeons in Ireland, Connolly Hospital, Blanchardstown, Dublin 15, IrelandDepartment of Endocrinology and Diabetes, Royal College of Surgeons in Ireland, Connolly Hospital, Blanchardstown, Dublin 15, IrelandDepartment of Endocrinology and Diabetes, Royal College of Surgeons in Ireland, Connolly Hospital, Blanchardstown, Dublin 15, IrelandDepartment of Endocrinology and Diabetes, Royal College of Surgeons in Ireland, Connolly Hospital, Blanchardstown, Dublin 15, IrelandDepartment of Endocrinology and Diabetes, Royal College of Surgeons in Ireland, Connolly Hospital, Blanchardstown, Dublin 15, IrelandDepartment of Endocrinology and Diabetes, Royal College of Surgeons in Ireland, Connolly Hospital, Blanchardstown, Dublin 15, IrelandDepartment of Endocrinology and Diabetes, Royal College of Surgeons in Ireland, Connolly Hospital, Blanchardstown, Dublin 15, IrelandAim. To investigate the association between sleep quality and duration with lipid and glycaemic control in Caucasian subjects with type 2 diabetes. Methods. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) in 114 type 2 diabetes (T2DM) subjects. Comparisons were made between subjects with different sleep quality and sleep duration. Hierarchical multiple regression analyses were used to determine contributors to metabolic parameters. Results. Subjects with poor sleep quality (PQ; PSQI ≥ 6) had higher systolic blood pressure, glycated haemoglobin, urine albumin : creatinine ratio (UAC), total cholesterol (TC), and triglycerides (TG) ( for all) compared to those with good sleep quality (GQ; PSQI ≤ 5). Long sleep duration (LSD) subjects had higher TC and short sleep duration (SSD) subjects had higher TG compared to those with medium sleep duration. Sleep duration and PSQI score were independent predictors of TC and low-density lipoprotein cholesterol (LDL), contributing to 14.0% and 6.1% of the total variance, respectively. Conclusions. In this Caucasian T2DM population, PQ is associated with adverse cardiovascular risk markers, and long and short sleep disruptions have an independent negative impact on lipids. Sleep assessment should be included as part of a diabetes clinic review.http://dx.doi.org/10.1155/2013/341506 |
| spellingShingle | Wan Aizad Wan Mahmood Mohd Shazli Draman Yusoff Lucy Ann Behan Andrea Di Perna Tommy Kyaw Tun John McDermott Seamus Sreenan Association between Sleep Disruption and Levels of Lipids in Caucasians with Type 2 Diabetes International Journal of Endocrinology |
| title | Association between Sleep Disruption and Levels of Lipids in Caucasians with Type 2 Diabetes |
| title_full | Association between Sleep Disruption and Levels of Lipids in Caucasians with Type 2 Diabetes |
| title_fullStr | Association between Sleep Disruption and Levels of Lipids in Caucasians with Type 2 Diabetes |
| title_full_unstemmed | Association between Sleep Disruption and Levels of Lipids in Caucasians with Type 2 Diabetes |
| title_short | Association between Sleep Disruption and Levels of Lipids in Caucasians with Type 2 Diabetes |
| title_sort | association between sleep disruption and levels of lipids in caucasians with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2013/341506 |
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