Culture dependent and independent approaches reveal the role of specific bacteria in human skin aging
Abstract Skin aging is a dynamic process involving a spectrum of phenotypic changes, making it an attractive model for studying microbiome‐phenotype interactions. Therefore, 822 facial microbial samples and 14 skin phenotypes from corresponding areas were assessed in a Chinese cohort. Porphyrins and...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | iMetaOmics |
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| Online Access: | https://doi.org/10.1002/imo2.26 |
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| _version_ | 1832575917372735488 |
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| author | Jing‐jing Xia Qian Zhong Zhi‐ming Li Qing‐zhen Wei Liu‐yi‐qi Jiang Cheng Duan Hui‐jue Jia Yi‐mei Tan Lian‐yi Han Jean Krutmann Jiucun Wang Xiao Liu |
| author_facet | Jing‐jing Xia Qian Zhong Zhi‐ming Li Qing‐zhen Wei Liu‐yi‐qi Jiang Cheng Duan Hui‐jue Jia Yi‐mei Tan Lian‐yi Han Jean Krutmann Jiucun Wang Xiao Liu |
| author_sort | Jing‐jing Xia |
| collection | DOAJ |
| description | Abstract Skin aging is a dynamic process involving a spectrum of phenotypic changes, making it an attractive model for studying microbiome‐phenotype interactions. Therefore, 822 facial microbial samples and 14 skin phenotypes from corresponding areas were assessed in a Chinese cohort. Porphyrins and the chronological age exhibited the most significant microbial variability. We further profiled the dynamics of the skin microbiome associated with age and aging phenotypes. Using a multiple linear regression model, we predicted premature/delayed aging‐related microbial species, mainly Moraxella osloensis and Cutibacterium acnes. We also validated the biological functions of the host‐microbe interactions in vitro. Moraxella osloensis isolated from healthy skin regulates collagen metabolism and extracellular matrix assembly, and promotes cell senescence in human keratinocytes and fibroblasts, making it potentially applicable in the development of antiaging interventions. |
| format | Article |
| id | doaj-art-6ac2ee645bfc4248888600345975739b |
| institution | Kabale University |
| issn | 2996-9506 2996-9514 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMetaOmics |
| spelling | doaj-art-6ac2ee645bfc4248888600345975739b2025-01-31T16:15:24ZengWileyiMetaOmics2996-95062996-95142024-12-0112n/an/a10.1002/imo2.26Culture dependent and independent approaches reveal the role of specific bacteria in human skin agingJing‐jing Xia0Qian Zhong1Zhi‐ming Li2Qing‐zhen Wei3Liu‐yi‐qi Jiang4Cheng Duan5Hui‐jue Jia6Yi‐mei Tan7Lian‐yi Han8Jean Krutmann9Jiucun Wang10Xiao Liu11State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute Fudan University Shanghai ChinaState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute Fudan University Shanghai ChinaState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute Fudan University Shanghai ChinaState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute Fudan University Shanghai ChinaState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute Fudan University Shanghai ChinaGreater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences Fudan University Guangzhou ChinaGreater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences Fudan University Guangzhou ChinaDepartment of Skin & Cosmetic Research Shanghai Skin Disease Hospital Shanghai ChinaGreater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences Fudan University Guangzhou ChinaState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute Fudan University Shanghai ChinaState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute Fudan University Shanghai ChinaShenzhen International Graduate School Tsinghua University Shenzhen ChinaAbstract Skin aging is a dynamic process involving a spectrum of phenotypic changes, making it an attractive model for studying microbiome‐phenotype interactions. Therefore, 822 facial microbial samples and 14 skin phenotypes from corresponding areas were assessed in a Chinese cohort. Porphyrins and the chronological age exhibited the most significant microbial variability. We further profiled the dynamics of the skin microbiome associated with age and aging phenotypes. Using a multiple linear regression model, we predicted premature/delayed aging‐related microbial species, mainly Moraxella osloensis and Cutibacterium acnes. We also validated the biological functions of the host‐microbe interactions in vitro. Moraxella osloensis isolated from healthy skin regulates collagen metabolism and extracellular matrix assembly, and promotes cell senescence in human keratinocytes and fibroblasts, making it potentially applicable in the development of antiaging interventions.https://doi.org/10.1002/imo2.26Cutibacterium acnesfungikeratinocyteMoraxella osloensisskin agingskin microbiome |
| spellingShingle | Jing‐jing Xia Qian Zhong Zhi‐ming Li Qing‐zhen Wei Liu‐yi‐qi Jiang Cheng Duan Hui‐jue Jia Yi‐mei Tan Lian‐yi Han Jean Krutmann Jiucun Wang Xiao Liu Culture dependent and independent approaches reveal the role of specific bacteria in human skin aging iMetaOmics Cutibacterium acnes fungi keratinocyte Moraxella osloensis skin aging skin microbiome |
| title | Culture dependent and independent approaches reveal the role of specific bacteria in human skin aging |
| title_full | Culture dependent and independent approaches reveal the role of specific bacteria in human skin aging |
| title_fullStr | Culture dependent and independent approaches reveal the role of specific bacteria in human skin aging |
| title_full_unstemmed | Culture dependent and independent approaches reveal the role of specific bacteria in human skin aging |
| title_short | Culture dependent and independent approaches reveal the role of specific bacteria in human skin aging |
| title_sort | culture dependent and independent approaches reveal the role of specific bacteria in human skin aging |
| topic | Cutibacterium acnes fungi keratinocyte Moraxella osloensis skin aging skin microbiome |
| url | https://doi.org/10.1002/imo2.26 |
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