Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor
To compare the antitumor efficacy and safety of transcatheter arterial chemoembolization (TACE) by epirubicin suspension (epirubicin suspension: epirubicin-iodized oil mixture without solution) to that by epirubicin emulsion (epirubicin emulsion: epirubicin-iodized oil mixture with solution), the ef...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/961986 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554497366294528 |
|---|---|
| author | Tatsuo Ueda Satoru Murata Takahiko Mine Shiro Onozawa Munehiko Onda Zenya Naito Yasuo Amano Shinichiro Kumita |
| author_facet | Tatsuo Ueda Satoru Murata Takahiko Mine Shiro Onozawa Munehiko Onda Zenya Naito Yasuo Amano Shinichiro Kumita |
| author_sort | Tatsuo Ueda |
| collection | DOAJ |
| description | To compare the antitumor efficacy and safety of transcatheter arterial chemoembolization (TACE) by epirubicin suspension (epirubicin suspension: epirubicin-iodized oil mixture without solution) to that by epirubicin emulsion (epirubicin emulsion: epirubicin-iodized oil mixture with solution), the efficacy of treatment by administration of either an epirubicin suspension or emulsion was examined in an animal model. Changes in plasma epirubicin concentration were compared over 24 h immediately after treatment, and enhanced ultrasonographic and histopathological analysis subsequently conducted 7 days after treatment to determine the growth ratio and proportion of viable tumor cells. The growth ratio and proportion of viable tumor cells were found to be significantly lower in the suspension group than in the emulsion group while the plasma epirubicin concentration was found to be significantly higher in the suspension group than in the emulsion group. These results indicate that administration of an epirubicin suspension is a superior form of TACE compared to that of administration of an epirubicin emulsion. |
| format | Article |
| id | doaj-art-6ac17d8111d345ce844b6e91fe7500ee |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-6ac17d8111d345ce844b6e91fe7500ee2025-02-03T05:51:21ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/961986961986Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 TumorTatsuo Ueda0Satoru Murata1Takahiko Mine2Shiro Onozawa3Munehiko Onda4Zenya Naito5Yasuo Amano6Shinichiro Kumita7Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, JapanDepartment of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, JapanDepartment of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, JapanDepartment of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, JapanDepartment of Integrative Oncological Pathology, Nippon Medical School, Bunkyo-ku, Tokyo 113-8603, JapanDepartment of Integrative Oncological Pathology, Nippon Medical School, Bunkyo-ku, Tokyo 113-8603, JapanDepartment of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, JapanDepartment of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, JapanTo compare the antitumor efficacy and safety of transcatheter arterial chemoembolization (TACE) by epirubicin suspension (epirubicin suspension: epirubicin-iodized oil mixture without solution) to that by epirubicin emulsion (epirubicin emulsion: epirubicin-iodized oil mixture with solution), the efficacy of treatment by administration of either an epirubicin suspension or emulsion was examined in an animal model. Changes in plasma epirubicin concentration were compared over 24 h immediately after treatment, and enhanced ultrasonographic and histopathological analysis subsequently conducted 7 days after treatment to determine the growth ratio and proportion of viable tumor cells. The growth ratio and proportion of viable tumor cells were found to be significantly lower in the suspension group than in the emulsion group while the plasma epirubicin concentration was found to be significantly higher in the suspension group than in the emulsion group. These results indicate that administration of an epirubicin suspension is a superior form of TACE compared to that of administration of an epirubicin emulsion.http://dx.doi.org/10.1100/2012/961986 |
| spellingShingle | Tatsuo Ueda Satoru Murata Takahiko Mine Shiro Onozawa Munehiko Onda Zenya Naito Yasuo Amano Shinichiro Kumita Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor The Scientific World Journal |
| title | Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor |
| title_full | Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor |
| title_fullStr | Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor |
| title_full_unstemmed | Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor |
| title_short | Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor |
| title_sort | comparison of epirubicin iodized oil suspension and emulsion for transcatheter arterial chemoembolization in vx2 tumor |
| url | http://dx.doi.org/10.1100/2012/961986 |
| work_keys_str_mv | AT tatsuoueda comparisonofepirubiciniodizedoilsuspensionandemulsionfortranscatheterarterialchemoembolizationinvx2tumor AT satorumurata comparisonofepirubiciniodizedoilsuspensionandemulsionfortranscatheterarterialchemoembolizationinvx2tumor AT takahikomine comparisonofepirubiciniodizedoilsuspensionandemulsionfortranscatheterarterialchemoembolizationinvx2tumor AT shiroonozawa comparisonofepirubiciniodizedoilsuspensionandemulsionfortranscatheterarterialchemoembolizationinvx2tumor AT munehikoonda comparisonofepirubiciniodizedoilsuspensionandemulsionfortranscatheterarterialchemoembolizationinvx2tumor AT zenyanaito comparisonofepirubiciniodizedoilsuspensionandemulsionfortranscatheterarterialchemoembolizationinvx2tumor AT yasuoamano comparisonofepirubiciniodizedoilsuspensionandemulsionfortranscatheterarterialchemoembolizationinvx2tumor AT shinichirokumita comparisonofepirubiciniodizedoilsuspensionandemulsionfortranscatheterarterialchemoembolizationinvx2tumor |