Pulmonary regional blood flow: validation of low-dose two-volume dynamic CT perfusion imaging in a swine model
Abstract Background We aimed to validate a low-dose two-volume pulmonary computed tomography (CT) perfusion technique. Methods Five Yorkshire swine (weight 53.6 ± 2.6 kg) underwent 21 independent CT perfusion acquisitions. Intravenous contrast material (370 mg/mL iodine, 0.5 mL/kg) and saline chaser...
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SpringerOpen
2025-02-01
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| Series: | European Radiology Experimental |
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| Online Access: | https://doi.org/10.1186/s41747-025-00556-3 |
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| author | Yixiao Zhao Nile Luu Logan Hubbard Shant Malkasian Sabee Molloi |
| author_facet | Yixiao Zhao Nile Luu Logan Hubbard Shant Malkasian Sabee Molloi |
| author_sort | Yixiao Zhao |
| collection | DOAJ |
| description | Abstract Background We aimed to validate a low-dose two-volume pulmonary computed tomography (CT) perfusion technique. Methods Five Yorkshire swine (weight 53.6 ± 2.6 kg) underwent 21 independent CT perfusion acquisitions. Intravenous contrast material (370 mg/mL iodine, 0.5 mL/kg) and saline chaser (0.5 mL/kg) were injected at 5 mL/s for each acquisition. Two-volume and multivolume dynamic CT perfusion data were acquired using a 320-slice CT, with multivolume measurements serving as the reference standard. The two-volume CT perfusion involved a low-dose (50 mA) volume scan before contrast injection and a diagnostic (300 mA) volume scan after bolus-tracking in the main pulmonary artery at the peak contrast enhancement. Multivolume CT perfusion included 15–20 volume scans for blood flow measurement. Paired sample t-test, linear regression, and Bland–Altman analysis compared both global and regional two-volume perfusion measurements to the reference standard. The reproducibility of the two-volume CT perfusion was assessed from two independent measurements under the same perfusion condition. Results Two-volume global perfusion measurements (P 2V) were related to reference multivolume (P MV) measurements by P 2V = 0.96 × P MV + 0.45 (r = 0.92), with a root-mean-square error of 1.29 mL/min/g and a root-mean-square deviation of 1.29 mL/min/g. The CT dose index for the two-volume and multivolume CT perfusion measurements were 9.3 mGy and 184.8 mGy, respectively. Conclusion We successfully validated a prospective, two-volume CT perfusion technique in a swine model. The findings affirm the feasibility of accurate and reproducible pulmonary blood flow measurement. Relevance statement This two-volume CT pulmonary perfusion technique, validated in a swine model, demonstrates the feasibility of blood flow measurement with a substantial reduction in radiation exposure. It could allow low-dose regional blood flow measurement in the assessment of pulmonary artery disease in humans. Key Points Lung perfusion can be measured in mL/min/g using a prospective, two-volume CT technique. Flow measurement is achievable in a swine model with a radiation dose as low as 9.3 mGy. CT angiography and perfusion can be acquired following a single contrast injection. Graphical Abstract |
| format | Article |
| id | doaj-art-6abfe3ced1ff4e4dba1eefe83610eaff |
| institution | DOAJ |
| issn | 2509-9280 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | European Radiology Experimental |
| spelling | doaj-art-6abfe3ced1ff4e4dba1eefe83610eaff2025-08-20T03:10:57ZengSpringerOpenEuropean Radiology Experimental2509-92802025-02-019111210.1186/s41747-025-00556-3Pulmonary regional blood flow: validation of low-dose two-volume dynamic CT perfusion imaging in a swine modelYixiao Zhao0Nile Luu1Logan Hubbard2Shant Malkasian3Sabee Molloi4Department of Radiological Sciences, University of California, IrvineDepartment of Radiological Sciences, University of California, IrvineDepartment of Radiological Sciences, University of California, IrvineDepartment of Radiological Sciences, University of California, IrvineDepartment of Radiological Sciences, University of California, IrvineAbstract Background We aimed to validate a low-dose two-volume pulmonary computed tomography (CT) perfusion technique. Methods Five Yorkshire swine (weight 53.6 ± 2.6 kg) underwent 21 independent CT perfusion acquisitions. Intravenous contrast material (370 mg/mL iodine, 0.5 mL/kg) and saline chaser (0.5 mL/kg) were injected at 5 mL/s for each acquisition. Two-volume and multivolume dynamic CT perfusion data were acquired using a 320-slice CT, with multivolume measurements serving as the reference standard. The two-volume CT perfusion involved a low-dose (50 mA) volume scan before contrast injection and a diagnostic (300 mA) volume scan after bolus-tracking in the main pulmonary artery at the peak contrast enhancement. Multivolume CT perfusion included 15–20 volume scans for blood flow measurement. Paired sample t-test, linear regression, and Bland–Altman analysis compared both global and regional two-volume perfusion measurements to the reference standard. The reproducibility of the two-volume CT perfusion was assessed from two independent measurements under the same perfusion condition. Results Two-volume global perfusion measurements (P 2V) were related to reference multivolume (P MV) measurements by P 2V = 0.96 × P MV + 0.45 (r = 0.92), with a root-mean-square error of 1.29 mL/min/g and a root-mean-square deviation of 1.29 mL/min/g. The CT dose index for the two-volume and multivolume CT perfusion measurements were 9.3 mGy and 184.8 mGy, respectively. Conclusion We successfully validated a prospective, two-volume CT perfusion technique in a swine model. The findings affirm the feasibility of accurate and reproducible pulmonary blood flow measurement. Relevance statement This two-volume CT pulmonary perfusion technique, validated in a swine model, demonstrates the feasibility of blood flow measurement with a substantial reduction in radiation exposure. It could allow low-dose regional blood flow measurement in the assessment of pulmonary artery disease in humans. Key Points Lung perfusion can be measured in mL/min/g using a prospective, two-volume CT technique. Flow measurement is achievable in a swine model with a radiation dose as low as 9.3 mGy. CT angiography and perfusion can be acquired following a single contrast injection. Graphical Abstracthttps://doi.org/10.1186/s41747-025-00556-3Computed tomography angiographyLungPerfusion imagingRadiation dosageSwine |
| spellingShingle | Yixiao Zhao Nile Luu Logan Hubbard Shant Malkasian Sabee Molloi Pulmonary regional blood flow: validation of low-dose two-volume dynamic CT perfusion imaging in a swine model European Radiology Experimental Computed tomography angiography Lung Perfusion imaging Radiation dosage Swine |
| title | Pulmonary regional blood flow: validation of low-dose two-volume dynamic CT perfusion imaging in a swine model |
| title_full | Pulmonary regional blood flow: validation of low-dose two-volume dynamic CT perfusion imaging in a swine model |
| title_fullStr | Pulmonary regional blood flow: validation of low-dose two-volume dynamic CT perfusion imaging in a swine model |
| title_full_unstemmed | Pulmonary regional blood flow: validation of low-dose two-volume dynamic CT perfusion imaging in a swine model |
| title_short | Pulmonary regional blood flow: validation of low-dose two-volume dynamic CT perfusion imaging in a swine model |
| title_sort | pulmonary regional blood flow validation of low dose two volume dynamic ct perfusion imaging in a swine model |
| topic | Computed tomography angiography Lung Perfusion imaging Radiation dosage Swine |
| url | https://doi.org/10.1186/s41747-025-00556-3 |
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