High-risk human papillomaviruses distribution in Romanian women with negative cytology
Introduction: Romania has the highest incidence and mortality rate of cervical cancer in Europe. The objective was to estimate the prevalence of high-risk human papillomavirus (hrHPV) genotypes and to evaluate the role of certain socio-behavioral factors in acquiring viral infection, in a cohort of...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Journal of Infection in Developing Countries
2019-04-01
|
| Series: | Journal of Infection in Developing Countries |
| Subjects: | |
| Online Access: | https://jidc.org/index.php/journal/article/view/11103 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850186677123809280 |
|---|---|
| author | Adriana Plesa Demetra Socolov Irina Huica Anca Botezatu Iulia Virginia Iancu Carmen Ungureanu Sergiu Teleman Adrian Albulescu Alina Fudulu Gabriela Anton |
| author_facet | Adriana Plesa Demetra Socolov Irina Huica Anca Botezatu Iulia Virginia Iancu Carmen Ungureanu Sergiu Teleman Adrian Albulescu Alina Fudulu Gabriela Anton |
| author_sort | Adriana Plesa |
| collection | DOAJ |
| description |
Introduction: Romania has the highest incidence and mortality rate of cervical cancer in Europe. The objective was to estimate the prevalence of high-risk human papillomavirus (hrHPV) genotypes and to evaluate the role of certain socio-behavioral factors in acquiring viral infection, in a cohort of Romanian women with negative Pap.
Methodology: In a prevalence study 611 women (aged 17-58 years) with negative Pap, with no known history of atypical cytology and valid HPV test were included. Each participant completed a questionnaire containing data on socio-behavioral factors. From 344 women aged between 30-58 years, 63 were randomly selected for a second examination (conventional cytology and HPV detection and genotyping) after twelve months.
Results: Of the 611 women, 19.80% were HPV positive, 14.73% infected with hrHPV. Differences in the prevalence of hrHPV (17.60% versus 12.50%) as single (13.01% vs 9.01%) and multiple infections (9.71% vs 3.49%) were noted between women under the age of 30 and above. Among socio-behavioral factors, marital status and multiple sexual partners correlate with HPV and hrHPV infection. At follow-up, from 34 HPV negative cases, 10 changed to positive (5 hrHPV), while 2 developed abnormal cytology. Out of the 29 HPV positive cases, 12 cleared the HPV infection and 17 retested positive of which 4 worsened their cytology.
Conclusions: In Romania, HPV infection is common in women with negative cytology. HPV genotyping is of epidemiological importance because the distribution of hrHPV types can determine the impact of prophylactic vaccines and the necessity of HPV testing as screening method.
|
| format | Article |
| id | doaj-art-6aaa40564b814653bca4b1b97f0f7dfe |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-6aaa40564b814653bca4b1b97f0f7dfe2025-08-20T02:16:18ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802019-04-01130410.3855/jidc.11103High-risk human papillomaviruses distribution in Romanian women with negative cytologyAdriana Plesa0Demetra Socolov1Irina Huica2Anca Botezatu3Iulia Virginia Iancu4Carmen Ungureanu5Sergiu Teleman6Adrian Albulescu7Alina Fudulu8Gabriela Anton9Molecular Virology Department, Stefan S. Nicolau Institute of Virology, Bucharest, RomaniaDepartment of Obstetrics and Gynecology, Grigore T. Popa University of Medicine and Pharmacy, Iassy, RomaniaMolecular Virology Department, Stefan S. Nicolau Institute of Virology, Bucharest, RomaniaMolecular Virology Department, Stefan S. Nicolau Institute of Virology, Bucharest, RomaniaMolecular Virology Department, Stefan S. Nicolau Institute of Virology, Bucharest, RomaniaDepartment of Pathology, Grigore T. Popa University of Medicine and Pharmacy, Iassy, RomaniaDepartment of Pathology, Grigore T. Popa University of Medicine and Pharmacy, Iassy, RomaniaMolecular Virology Department, Stefan S. Nicolau Institute of Virology, Bucharest, RomaniaMolecular Virology Department, Stefan S. Nicolau Institute of Virology, Bucharest, RomaniaMolecular Virology Department, Stefan S. Nicolau Institute of Virology, Bucharest, Romania Introduction: Romania has the highest incidence and mortality rate of cervical cancer in Europe. The objective was to estimate the prevalence of high-risk human papillomavirus (hrHPV) genotypes and to evaluate the role of certain socio-behavioral factors in acquiring viral infection, in a cohort of Romanian women with negative Pap. Methodology: In a prevalence study 611 women (aged 17-58 years) with negative Pap, with no known history of atypical cytology and valid HPV test were included. Each participant completed a questionnaire containing data on socio-behavioral factors. From 344 women aged between 30-58 years, 63 were randomly selected for a second examination (conventional cytology and HPV detection and genotyping) after twelve months. Results: Of the 611 women, 19.80% were HPV positive, 14.73% infected with hrHPV. Differences in the prevalence of hrHPV (17.60% versus 12.50%) as single (13.01% vs 9.01%) and multiple infections (9.71% vs 3.49%) were noted between women under the age of 30 and above. Among socio-behavioral factors, marital status and multiple sexual partners correlate with HPV and hrHPV infection. At follow-up, from 34 HPV negative cases, 10 changed to positive (5 hrHPV), while 2 developed abnormal cytology. Out of the 29 HPV positive cases, 12 cleared the HPV infection and 17 retested positive of which 4 worsened their cytology. Conclusions: In Romania, HPV infection is common in women with negative cytology. HPV genotyping is of epidemiological importance because the distribution of hrHPV types can determine the impact of prophylactic vaccines and the necessity of HPV testing as screening method. https://jidc.org/index.php/journal/article/view/11103hrHPVNILMbehavioral factorsscreening |
| spellingShingle | Adriana Plesa Demetra Socolov Irina Huica Anca Botezatu Iulia Virginia Iancu Carmen Ungureanu Sergiu Teleman Adrian Albulescu Alina Fudulu Gabriela Anton High-risk human papillomaviruses distribution in Romanian women with negative cytology Journal of Infection in Developing Countries hrHPV NILM behavioral factors screening |
| title | High-risk human papillomaviruses distribution in Romanian women with negative cytology |
| title_full | High-risk human papillomaviruses distribution in Romanian women with negative cytology |
| title_fullStr | High-risk human papillomaviruses distribution in Romanian women with negative cytology |
| title_full_unstemmed | High-risk human papillomaviruses distribution in Romanian women with negative cytology |
| title_short | High-risk human papillomaviruses distribution in Romanian women with negative cytology |
| title_sort | high risk human papillomaviruses distribution in romanian women with negative cytology |
| topic | hrHPV NILM behavioral factors screening |
| url | https://jidc.org/index.php/journal/article/view/11103 |
| work_keys_str_mv | AT adrianaplesa highriskhumanpapillomavirusesdistributioninromanianwomenwithnegativecytology AT demetrasocolov highriskhumanpapillomavirusesdistributioninromanianwomenwithnegativecytology AT irinahuica highriskhumanpapillomavirusesdistributioninromanianwomenwithnegativecytology AT ancabotezatu highriskhumanpapillomavirusesdistributioninromanianwomenwithnegativecytology AT iuliavirginiaiancu highriskhumanpapillomavirusesdistributioninromanianwomenwithnegativecytology AT carmenungureanu highriskhumanpapillomavirusesdistributioninromanianwomenwithnegativecytology AT sergiuteleman highriskhumanpapillomavirusesdistributioninromanianwomenwithnegativecytology AT adrianalbulescu highriskhumanpapillomavirusesdistributioninromanianwomenwithnegativecytology AT alinafudulu highriskhumanpapillomavirusesdistributioninromanianwomenwithnegativecytology AT gabrielaanton highriskhumanpapillomavirusesdistributioninromanianwomenwithnegativecytology |