Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial Hepatectomy
Liver ischemia-reperfusion injury (IRI) and regeneration deficiency are two major challenges for surgery patients with chronic liver disease. As a survival factor for hepatocytes, interleukin 22 (IL-22) plays an important role in hepatoprotection and the promotion of regeneration after hepatectomy....
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/5241526 |
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| author | Heng Zhou Guomin Xie Yudi Mao Ke Zhou Ruixue Ren Qihong Zhao Hua Wang Shi Yin |
| author_facet | Heng Zhou Guomin Xie Yudi Mao Ke Zhou Ruixue Ren Qihong Zhao Hua Wang Shi Yin |
| author_sort | Heng Zhou |
| collection | DOAJ |
| description | Liver ischemia-reperfusion injury (IRI) and regeneration deficiency are two major challenges for surgery patients with chronic liver disease. As a survival factor for hepatocytes, interleukin 22 (IL-22) plays an important role in hepatoprotection and the promotion of regeneration after hepatectomy. In this study, we aim to investigate the roles of an interleukin 22 fusion protein (IL-22-FP) in mice with a predamaged liver after a two-third partial hepatectomy (PHx). Predamaged livers in mice were induced by concanavalin A (ConA)/carbon tetrachloride (CCl4) following PHx with or without IL-22-FP treatment. A hepatic IRI mouse model was also used to determine the hepatoprotective effects of IL-22-FP. In the ConA/CCl4 model, IL-22-FP treatment alleviated liver injury and accelerated hepatocyte proliferation. Administration of IL-22-FP activated the hepatic signal transducer and activator of transcription 3 (STAT3) and upregulated the expression of many mitogenic proteins. IL-22-FP treatment prior to IRI effectively reduced liver damage through decreased aminotransferase and improved liver histology. In conclusion, IL-22-FP promotes liver regeneration in mice with predamaged livers following PHx and alleviates IRI-induced liver injury. Our study suggests that IL-22-FP may represent a promising therapeutic drug against regeneration deficiency and liver IRI in patients who have undergone PHx. |
| format | Article |
| id | doaj-art-6aa5cfceda8d4dfebb63a9904be8d438 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-6aa5cfceda8d4dfebb63a9904be8d4382025-02-03T05:46:26ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/52415265241526Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial HepatectomyHeng Zhou0Guomin Xie1Yudi Mao2Ke Zhou3Ruixue Ren4Qihong Zhao5Hua Wang6Shi Yin7Department of Geriatrics, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, ChinaSchool of Pharmacy, Anhui Medical University, Hefei 230032, ChinaDepartment of Geriatrics, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, ChinaSchool of Pharmacy, Anhui Medical University, Hefei 230032, ChinaInstitute for Liver Disease, Anhui Medical University, Hefei 230032, ChinaDepartment of Food and Nutrition Hygiene, School of Public Health, Anhui Medical University, Hefei 230032, ChinaInstitute for Liver Disease, Anhui Medical University, Hefei 230032, ChinaDepartment of Geriatrics, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, ChinaLiver ischemia-reperfusion injury (IRI) and regeneration deficiency are two major challenges for surgery patients with chronic liver disease. As a survival factor for hepatocytes, interleukin 22 (IL-22) plays an important role in hepatoprotection and the promotion of regeneration after hepatectomy. In this study, we aim to investigate the roles of an interleukin 22 fusion protein (IL-22-FP) in mice with a predamaged liver after a two-third partial hepatectomy (PHx). Predamaged livers in mice were induced by concanavalin A (ConA)/carbon tetrachloride (CCl4) following PHx with or without IL-22-FP treatment. A hepatic IRI mouse model was also used to determine the hepatoprotective effects of IL-22-FP. In the ConA/CCl4 model, IL-22-FP treatment alleviated liver injury and accelerated hepatocyte proliferation. Administration of IL-22-FP activated the hepatic signal transducer and activator of transcription 3 (STAT3) and upregulated the expression of many mitogenic proteins. IL-22-FP treatment prior to IRI effectively reduced liver damage through decreased aminotransferase and improved liver histology. In conclusion, IL-22-FP promotes liver regeneration in mice with predamaged livers following PHx and alleviates IRI-induced liver injury. Our study suggests that IL-22-FP may represent a promising therapeutic drug against regeneration deficiency and liver IRI in patients who have undergone PHx.http://dx.doi.org/10.1155/2018/5241526 |
| spellingShingle | Heng Zhou Guomin Xie Yudi Mao Ke Zhou Ruixue Ren Qihong Zhao Hua Wang Shi Yin Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial Hepatectomy Journal of Immunology Research |
| title | Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial Hepatectomy |
| title_full | Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial Hepatectomy |
| title_fullStr | Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial Hepatectomy |
| title_full_unstemmed | Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial Hepatectomy |
| title_short | Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial Hepatectomy |
| title_sort | enhanced regeneration and hepatoprotective effects of interleukin 22 fusion protein on a predamaged liver undergoing partial hepatectomy |
| url | http://dx.doi.org/10.1155/2018/5241526 |
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