Resistant Hypertension and Obstructive Sleep Apnea: The Sparring Partners
Enhanced target organ damage and cardiovascular morbidity represent common issues observed in both resistant hypertension and obstructive sleep apnea. Common pathophysiological features and risk factors justify their coexistence, especially in individuals with increased upper-body adiposity. Impaire...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2011/947246 |
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| _version_ | 1832566901050441728 |
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| author | Costas Thomopoulos Helena Michalopoulou Alexandros Kasiakogias Anna Kefala Thomas Makris |
| author_facet | Costas Thomopoulos Helena Michalopoulou Alexandros Kasiakogias Anna Kefala Thomas Makris |
| author_sort | Costas Thomopoulos |
| collection | DOAJ |
| description | Enhanced target organ damage and cardiovascular morbidity represent common issues observed in both resistant hypertension and obstructive sleep apnea. Common pathophysiological features and risk factors justify their coexistence, especially in individuals with increased upper-body adiposity. Impaired sodium handling, sympathetic activation, accelerated arterial stiffening, and impaired cardiorenal hemodynamics contribute to drug-resistant hypertension development in obstructive sleep apnea. Effective CPAP therapy qualifies as an effective “add-on” to the underlying antihypertensive pharmacological therapy, and emerging evidence underlines the favorable effect of mineralocorticoid antagonists on both resistant hypertension and obstructive sleep apnea treatment. |
| format | Article |
| id | doaj-art-6a9b217ea4854c12b73c7f5015a014d9 |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-6a9b217ea4854c12b73c7f5015a014d92025-02-03T01:02:56ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/947246947246Resistant Hypertension and Obstructive Sleep Apnea: The Sparring PartnersCostas Thomopoulos0Helena Michalopoulou1Alexandros Kasiakogias2Anna Kefala3Thomas Makris4Department of Cardiology, Elena Venizelou Hospital, 2 Elena Venizelou Sqr., Athens 11521, GreeceDepartment of Cardiology, Metaxa Cancer Hospital, 51 Mpotassi Str., Piraeus 18537, GreeceFirst Cardiology Clinic, University of Athens, Hippokration Hospital, 114 Vas. Sofias Str., Athens 11527, GreeceFirst Cardiology Clinic, University of Athens, Hippokration Hospital, 114 Vas. Sofias Str., Athens 11527, GreeceDepartment of Cardiology, Elena Venizelou Hospital, 2 Elena Venizelou Sqr., Athens 11521, GreeceEnhanced target organ damage and cardiovascular morbidity represent common issues observed in both resistant hypertension and obstructive sleep apnea. Common pathophysiological features and risk factors justify their coexistence, especially in individuals with increased upper-body adiposity. Impaired sodium handling, sympathetic activation, accelerated arterial stiffening, and impaired cardiorenal hemodynamics contribute to drug-resistant hypertension development in obstructive sleep apnea. Effective CPAP therapy qualifies as an effective “add-on” to the underlying antihypertensive pharmacological therapy, and emerging evidence underlines the favorable effect of mineralocorticoid antagonists on both resistant hypertension and obstructive sleep apnea treatment.http://dx.doi.org/10.4061/2011/947246 |
| spellingShingle | Costas Thomopoulos Helena Michalopoulou Alexandros Kasiakogias Anna Kefala Thomas Makris Resistant Hypertension and Obstructive Sleep Apnea: The Sparring Partners International Journal of Hypertension |
| title | Resistant Hypertension and Obstructive Sleep Apnea: The Sparring Partners |
| title_full | Resistant Hypertension and Obstructive Sleep Apnea: The Sparring Partners |
| title_fullStr | Resistant Hypertension and Obstructive Sleep Apnea: The Sparring Partners |
| title_full_unstemmed | Resistant Hypertension and Obstructive Sleep Apnea: The Sparring Partners |
| title_short | Resistant Hypertension and Obstructive Sleep Apnea: The Sparring Partners |
| title_sort | resistant hypertension and obstructive sleep apnea the sparring partners |
| url | http://dx.doi.org/10.4061/2011/947246 |
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