Toll like receptor 2 mediated exacerbation of sepsis associated acute kidney injury by renal congestion in mice

Toll like receptor 2 mediated exacerbation of sepsis associated acute kidney injury by renal congestion in mice

Abstract Renal congestion is a key factor in renal dysfunction associated with heart failure. We previously reported that renal congestion worsened renal ischemia-reperfusion in a murine model. However, its impact on sepsis-associated acute kidney injury (SA-AKI), the leading cause of AKI, remains u...

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Main Authors: Itaru Nakamura, Minato Umehara, Aya Yagi-Tomita, Satomi Yamamoto, Shinji Sawai, Masashi Nakamura, Atsushi Minamida, Hiroko Yamauchi-Sawada, Yasuto Sunahara, Yayoi Matoba, Natsuko Okuno-Ozeki, Kunihiro Nakai, Tomohiro Nakata, Takashi Kitani, Noriyuki Yamashita, Kazumi Komaki, Yuhei Kirita, Keiichi Tamagaki, Satoaki Matoba, Tetsuro Kusaba
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Renal congestion
Toll-like receptor 2
Sepsis
Acute kidney injury
Online Access:https://doi.org/10.1038/s41598-025-05878-1
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