Enhancement of Latent Inhibition by Chronic Mild Stress in Rats Submitted to Emotional Response Conditioning
This work evaluated the influence of chronic mild stress on latent inhibition (LI) in rats, using a conditioned emotional response (CER) procedure. Rats were assigned to four groups: a non pre-exposed control group (NPC), a non pre-exposed stressed group (NPS), a preexposed control group (PC), and a...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2003-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2003.327 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565105770889216 |
|---|---|
| author | Liana Lins Melo Elenice A. de Moraes Ferrari Nancy Airoldi Teixeira Guy Sandner |
| author_facet | Liana Lins Melo Elenice A. de Moraes Ferrari Nancy Airoldi Teixeira Guy Sandner |
| author_sort | Liana Lins Melo |
| collection | DOAJ |
| description | This work evaluated the influence of
chronic mild stress on latent inhibition (LI) in
rats, using a conditioned emotional response
(CER) procedure. Rats were assigned to four
groups: a non pre-exposed control group (NPC),
a non pre-exposed stressed group (NPS), a preexposed
control group (PC), and a pre-exposed
stressed group (PS). Stressed animals were
submitted to a chronic mild stress (CMS)
regimen for three weeks. The off-baseline
conditioned emotional response procedure had
four phases: licking response training, tone-
shock conditioning, retraining, and testing.
Conditioning consisted of 2 tone (30 s) and
shock (0.5 s) associations. Tone-shock conditioning
evidenced by NPS and NPC groups
suggests that stress did not interfere with the
expression of a conditioned emotional response.
Pre-exposure was carried out using 6 tones
(30 s) during 2 sessions before conditioning.
Prior exposure to the tone resulted in a
decrease in learning that was greater in
stressed animals. The results indicate an
increase in latent inhibition induced by chronic
mild stress. Such LI potentiation after CMS
may be related to dopamine (DA) neurotransmission
reduction in the central nervous
system. |
| format | Article |
| id | doaj-art-6a888e73fba14e58a5e29a23de7f2b88 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-6a888e73fba14e58a5e29a23de7f2b882025-02-03T01:09:14ZengWileyNeural Plasticity2090-59041687-54432003-01-0110432733310.1155/NP.2003.327Enhancement of Latent Inhibition by Chronic Mild Stress in Rats Submitted to Emotional Response ConditioningLiana Lins Melo0Elenice A. de Moraes Ferrari1Nancy Airoldi Teixeira2Guy Sandner3Laboratório de Sistemas Neurais e Comportamento, Departamento de Fisiologia e Biofisica, IB, Universidade Estadual de Campinas, Cidade Universitária Prof. Zeferino Vaz, Campinas, SP 13083-970, BrazilLaboratório de Sistemas Neurais e Comportamento, Departamento de Fisiologia e Biofisica, IB, Universidade Estadual de Campinas, Cidade Universitária Prof. Zeferino Vaz, Campinas, SP 13083-970, BrazilDepartamento de Farmacologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Cidade Universitária Prof. Zeferino Vaz, Campinas, SP 13083-970, BrazilLaboratoire de Psychopathologie et de Psychopharmacologie de la Cognition, U 405 INSERM, Institut de Physiologie, Faculté de Médecine, Université Louis Pasteur,11 rue Humann, Strasbourg Cédex F-67085, FranceThis work evaluated the influence of chronic mild stress on latent inhibition (LI) in rats, using a conditioned emotional response (CER) procedure. Rats were assigned to four groups: a non pre-exposed control group (NPC), a non pre-exposed stressed group (NPS), a preexposed control group (PC), and a pre-exposed stressed group (PS). Stressed animals were submitted to a chronic mild stress (CMS) regimen for three weeks. The off-baseline conditioned emotional response procedure had four phases: licking response training, tone- shock conditioning, retraining, and testing. Conditioning consisted of 2 tone (30 s) and shock (0.5 s) associations. Tone-shock conditioning evidenced by NPS and NPC groups suggests that stress did not interfere with the expression of a conditioned emotional response. Pre-exposure was carried out using 6 tones (30 s) during 2 sessions before conditioning. Prior exposure to the tone resulted in a decrease in learning that was greater in stressed animals. The results indicate an increase in latent inhibition induced by chronic mild stress. Such LI potentiation after CMS may be related to dopamine (DA) neurotransmission reduction in the central nervous system.http://dx.doi.org/10.1155/NP.2003.327 |
| spellingShingle | Liana Lins Melo Elenice A. de Moraes Ferrari Nancy Airoldi Teixeira Guy Sandner Enhancement of Latent Inhibition by Chronic Mild Stress in Rats Submitted to Emotional Response Conditioning Neural Plasticity |
| title | Enhancement of Latent Inhibition by Chronic Mild Stress in Rats
Submitted to Emotional Response Conditioning |
| title_full | Enhancement of Latent Inhibition by Chronic Mild Stress in Rats
Submitted to Emotional Response Conditioning |
| title_fullStr | Enhancement of Latent Inhibition by Chronic Mild Stress in Rats
Submitted to Emotional Response Conditioning |
| title_full_unstemmed | Enhancement of Latent Inhibition by Chronic Mild Stress in Rats
Submitted to Emotional Response Conditioning |
| title_short | Enhancement of Latent Inhibition by Chronic Mild Stress in Rats
Submitted to Emotional Response Conditioning |
| title_sort | enhancement of latent inhibition by chronic mild stress in rats submitted to emotional response conditioning |
| url | http://dx.doi.org/10.1155/NP.2003.327 |
| work_keys_str_mv | AT lianalinsmelo enhancementoflatentinhibitionbychronicmildstressinratssubmittedtoemotionalresponseconditioning AT eleniceademoraesferrari enhancementoflatentinhibitionbychronicmildstressinratssubmittedtoemotionalresponseconditioning AT nancyairolditeixeira enhancementoflatentinhibitionbychronicmildstressinratssubmittedtoemotionalresponseconditioning AT guysandner enhancementoflatentinhibitionbychronicmildstressinratssubmittedtoemotionalresponseconditioning |