Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay
Clinical evidence shows that in males obesity is frequently associated with hypogonadism and vice versa; also, low testosterone levels have been considered a “hallmark” of metabolic syndrome in men. These observations indicate that there is a strict connection between anatomically and functionally d...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/789653 |
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| author | Caterina Mammi Matilde Calanchini Antonella Antelmi Francesca Cinti Giuseppe M. C. Rosano Andrea Lenzi Massimiliano Caprio Andrea Fabbri |
| author_facet | Caterina Mammi Matilde Calanchini Antonella Antelmi Francesca Cinti Giuseppe M. C. Rosano Andrea Lenzi Massimiliano Caprio Andrea Fabbri |
| author_sort | Caterina Mammi |
| collection | DOAJ |
| description | Clinical evidence shows that in males obesity is frequently associated with hypogonadism and vice versa; also, low testosterone levels have been considered a “hallmark” of metabolic syndrome in men. These observations indicate that there is a strict connection between anatomically and functionally distinct cell types such as white adipocytes and Leydig cells, that synthesize testosterone. Adipose tissue is able to control several functions of the testis through its products secreted in the bloodstream. On the other hand, circulating levels of testosterone and estradiol deeply affect adipocyte proliferation, differentiation, and fat mass distribution, hereby controlling critical metabolic functions, such as food intake, insulin sensitivity, vascular reactivity, and immunity. This paper highlights the existing clinical and experimental evidence linking androgens and adipose tissue and illustrates the consequences occurring when the balance between fat mass distribution and eugonadism is lost. |
| format | Article |
| id | doaj-art-6a7d15c230cb4eec80ea5fa7001b71b3 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6a7d15c230cb4eec80ea5fa7001b71b32025-02-03T01:02:46ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/789653789653Androgens and Adipose Tissue in Males: A Complex and Reciprocal InterplayCaterina Mammi0Matilde Calanchini1Antonella Antelmi2Francesca Cinti3Giuseppe M. C. Rosano4Andrea Lenzi5Massimiliano Caprio6Andrea Fabbri7Centre of Clinical and Basic Research, Department of Medical Sciences, IRCCS San Raffaele Pisana, 235 00163 Rome, ItalyUnit of Endocrinology, S. Eugenio & CTO A. Alesini Hospitals, Department of Internal Medicine, University of Rome “Tor Vergata”, Rome, ItalyCentre of Clinical and Basic Research, Department of Medical Sciences, IRCCS San Raffaele Pisana, 235 00163 Rome, ItalyCentre of Clinical and Basic Research, Department of Medical Sciences, IRCCS San Raffaele Pisana, 235 00163 Rome, ItalyCentre of Clinical and Basic Research, Department of Medical Sciences, IRCCS San Raffaele Pisana, 235 00163 Rome, ItalyDepartment of Medical Pathophysiology, University of Rome “La Sapienza”, Rome, ItalyCentre of Clinical and Basic Research, Department of Medical Sciences, IRCCS San Raffaele Pisana, 235 00163 Rome, ItalyUnit of Endocrinology, S. Eugenio & CTO A. Alesini Hospitals, Department of Internal Medicine, University of Rome “Tor Vergata”, Rome, ItalyClinical evidence shows that in males obesity is frequently associated with hypogonadism and vice versa; also, low testosterone levels have been considered a “hallmark” of metabolic syndrome in men. These observations indicate that there is a strict connection between anatomically and functionally distinct cell types such as white adipocytes and Leydig cells, that synthesize testosterone. Adipose tissue is able to control several functions of the testis through its products secreted in the bloodstream. On the other hand, circulating levels of testosterone and estradiol deeply affect adipocyte proliferation, differentiation, and fat mass distribution, hereby controlling critical metabolic functions, such as food intake, insulin sensitivity, vascular reactivity, and immunity. This paper highlights the existing clinical and experimental evidence linking androgens and adipose tissue and illustrates the consequences occurring when the balance between fat mass distribution and eugonadism is lost.http://dx.doi.org/10.1155/2012/789653 |
| spellingShingle | Caterina Mammi Matilde Calanchini Antonella Antelmi Francesca Cinti Giuseppe M. C. Rosano Andrea Lenzi Massimiliano Caprio Andrea Fabbri Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay International Journal of Endocrinology |
| title | Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay |
| title_full | Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay |
| title_fullStr | Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay |
| title_full_unstemmed | Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay |
| title_short | Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay |
| title_sort | androgens and adipose tissue in males a complex and reciprocal interplay |
| url | http://dx.doi.org/10.1155/2012/789653 |
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