Correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age-related macular degeneration
Purpose Subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are associated with systemic vascular diseases that compromise ocular perfusion. We demonstrate that SDDs are associated with decreased ellipsoid zone (EZ) thickness, further evidence of hypoxic damage.Methods Pos...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-08-01
|
| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/9/1/e001622.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832086935562092544 |
|---|---|
| author | Richard B Rosen Roland Theodore Smith Gerardo Ledesma-Gil Oscar Otero-Marquez Yuehong Tong Katy Tai Gareth M C Lema Raymond Matthew Bellis Yang Fei Brandon Le |
| author_facet | Richard B Rosen Roland Theodore Smith Gerardo Ledesma-Gil Oscar Otero-Marquez Yuehong Tong Katy Tai Gareth M C Lema Raymond Matthew Bellis Yang Fei Brandon Le |
| author_sort | Richard B Rosen |
| collection | DOAJ |
| description | Purpose Subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are associated with systemic vascular diseases that compromise ocular perfusion. We demonstrate that SDDs are associated with decreased ellipsoid zone (EZ) thickness, further evidence of hypoxic damage.Methods Post hoc analysis of a cross-sectional study. 165 AMD subjects (aged 51–100; 61% women). Spectral-domain optical coherence tomography was obtained in both eyes. Masked readers assigned subjects to three groups: drusen only, SDD+drusen (SDD+D) and SDD only. EZ thickness was measured subfoveally and 2000 µm nasally, temporally, superiorly and inferiorly from the fovea. Univariate testing was performed using two-tailed t-tests with Bonferroni correction.Results The mean EZ thickness differences between the SDD+D and drusen-only groups were (in μm) 1.10, 0.67, 1.21, 1.10 and 0.50 at the foveal, nasal, temporal, superior and inferior locations, respectively (p=0.08 inferiorly, otherwise p≤0.01); between the SDD-only and drusen-only groups, the differences were 3.48, 2.48, 2.42, 2.08 and 1.42 (p≤0.0002). Differences in EZ thicknesses across all subjects and between groups were not significantly different based on gender, race or age.Conclusion Subjects with SDDs (±drusen) had thinner EZs than those with drusen only, and the inferior EZ was least affected. EZs were thinnest in SDD-only subjects. This thinning gradation is consistent with progressive destruction of highly oxygen-sensitive mitochondria in the EZ from hypoxia. These findings support the reduced ophthalmic perfusion hypothesis for the formation of SDDs secondary to high-risk systemic vasculopathy. |
| format | Article |
| id | doaj-art-6a71762f79104e5386ee5987993215d5 |
| institution | Kabale University |
| issn | 2397-3269 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj-art-6a71762f79104e5386ee5987993215d52025-02-06T09:15:13ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692024-08-019110.1136/bmjophth-2023-001622Correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age-related macular degenerationRichard B Rosen0Roland Theodore Smith1Gerardo Ledesma-Gil2Oscar Otero-Marquez3Yuehong Tong4Katy Tai5Gareth M C Lema6Raymond Matthew Bellis7Yang Fei8Brandon Le9Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USAOphthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USARetina, Instituto de Oftalmologia Fundacion Conde de Valenciana IAP, Mexico City, MexicoOphthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USAOphthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USAOphthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USAOphthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USAOphthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USAOphthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USAOphthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USAPurpose Subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are associated with systemic vascular diseases that compromise ocular perfusion. We demonstrate that SDDs are associated with decreased ellipsoid zone (EZ) thickness, further evidence of hypoxic damage.Methods Post hoc analysis of a cross-sectional study. 165 AMD subjects (aged 51–100; 61% women). Spectral-domain optical coherence tomography was obtained in both eyes. Masked readers assigned subjects to three groups: drusen only, SDD+drusen (SDD+D) and SDD only. EZ thickness was measured subfoveally and 2000 µm nasally, temporally, superiorly and inferiorly from the fovea. Univariate testing was performed using two-tailed t-tests with Bonferroni correction.Results The mean EZ thickness differences between the SDD+D and drusen-only groups were (in μm) 1.10, 0.67, 1.21, 1.10 and 0.50 at the foveal, nasal, temporal, superior and inferior locations, respectively (p=0.08 inferiorly, otherwise p≤0.01); between the SDD-only and drusen-only groups, the differences were 3.48, 2.48, 2.42, 2.08 and 1.42 (p≤0.0002). Differences in EZ thicknesses across all subjects and between groups were not significantly different based on gender, race or age.Conclusion Subjects with SDDs (±drusen) had thinner EZs than those with drusen only, and the inferior EZ was least affected. EZs were thinnest in SDD-only subjects. This thinning gradation is consistent with progressive destruction of highly oxygen-sensitive mitochondria in the EZ from hypoxia. These findings support the reduced ophthalmic perfusion hypothesis for the formation of SDDs secondary to high-risk systemic vasculopathy.https://bmjophth.bmj.com/content/9/1/e001622.full |
| spellingShingle | Richard B Rosen Roland Theodore Smith Gerardo Ledesma-Gil Oscar Otero-Marquez Yuehong Tong Katy Tai Gareth M C Lema Raymond Matthew Bellis Yang Fei Brandon Le Correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age-related macular degeneration BMJ Open Ophthalmology |
| title | Correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age-related macular degeneration |
| title_full | Correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age-related macular degeneration |
| title_fullStr | Correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age-related macular degeneration |
| title_full_unstemmed | Correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age-related macular degeneration |
| title_short | Correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age-related macular degeneration |
| title_sort | correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age related macular degeneration |
| url | https://bmjophth.bmj.com/content/9/1/e001622.full |
| work_keys_str_mv | AT richardbrosen correlationbetweenellipsoidzonethicknessandthepresenceofsubretinaldrusenoiddepositsinagerelatedmaculardegeneration AT rolandtheodoresmith correlationbetweenellipsoidzonethicknessandthepresenceofsubretinaldrusenoiddepositsinagerelatedmaculardegeneration AT gerardoledesmagil correlationbetweenellipsoidzonethicknessandthepresenceofsubretinaldrusenoiddepositsinagerelatedmaculardegeneration AT oscaroteromarquez correlationbetweenellipsoidzonethicknessandthepresenceofsubretinaldrusenoiddepositsinagerelatedmaculardegeneration AT yuehongtong correlationbetweenellipsoidzonethicknessandthepresenceofsubretinaldrusenoiddepositsinagerelatedmaculardegeneration AT katytai correlationbetweenellipsoidzonethicknessandthepresenceofsubretinaldrusenoiddepositsinagerelatedmaculardegeneration AT garethmclema correlationbetweenellipsoidzonethicknessandthepresenceofsubretinaldrusenoiddepositsinagerelatedmaculardegeneration AT raymondmatthewbellis correlationbetweenellipsoidzonethicknessandthepresenceofsubretinaldrusenoiddepositsinagerelatedmaculardegeneration AT yangfei correlationbetweenellipsoidzonethicknessandthepresenceofsubretinaldrusenoiddepositsinagerelatedmaculardegeneration AT brandonle correlationbetweenellipsoidzonethicknessandthepresenceofsubretinaldrusenoiddepositsinagerelatedmaculardegeneration |