Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19
Objective. To systematically explore genetic polymorphisms associated with the clinical outcomes in SARS-CoV infection in humans. Methods. This comprehensive literature search comprised available English papers published in PubMed/Medline and SCOPUS databases following the PRISMA-P guidelines and PI...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2020/6901217 |
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| author | Omar Ramos-Lopez Lidia Daimiel Ana Ramírez de Molina Diego Martínez-Urbistondo Juan A. Vargas J. Alfredo Martínez |
| author_facet | Omar Ramos-Lopez Lidia Daimiel Ana Ramírez de Molina Diego Martínez-Urbistondo Juan A. Vargas J. Alfredo Martínez |
| author_sort | Omar Ramos-Lopez |
| collection | DOAJ |
| description | Objective. To systematically explore genetic polymorphisms associated with the clinical outcomes in SARS-CoV infection in humans. Methods. This comprehensive literature search comprised available English papers published in PubMed/Medline and SCOPUS databases following the PRISMA-P guidelines and PICO/AXIS criteria. Results. Twenty-nine polymorphisms located in 21 genes were identified as associated with SARS-CoV susceptibility/resistance, disease severity, and clinical outcomes predominantly in Asian populations. Thus, genes implicated in key pathophysiological processes such as the mechanisms related to the entry of the virus into the cell and the antiviral immune/inflammatory responses were identified. Conclusions. Although caution must be taken, the results of this systematic review suggest that multiple genetic polymorphisms are associated with SARS-CoV infection features by affecting virus pathogenesis and host immune response, which could have important applications for the study and understanding of genetics in SARS-CoV-2/COVID-19 and for personalized translational clinical practice depending on the population studied and associated environments. |
| format | Article |
| id | doaj-art-6a41c59e0ec042a5abee4f6a399d6a45 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-6a41c59e0ec042a5abee4f6a399d6a452025-02-03T05:53:53ZengWileyInternational Journal of Genomics2314-436X2314-43782020-01-01202010.1155/2020/69012176901217Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19Omar Ramos-Lopez0Lidia Daimiel1Ana Ramírez de Molina2Diego Martínez-Urbistondo3Juan A. Vargas4J. Alfredo Martínez5Faculty of Medicine and Psychology, Autonomous University of Baja California, Tijuana, Baja California, MexicoNutritional Control of the Epigenome Group, IMDEA Food, CEI UAM + CSIC, Madrid, SpainMolecular Oncology and Nutritional Genomics of Cancer, IMDEA-Food Institute, CEI UAM + CSIC, Madrid, SpainHospital Universitario HM Sanchinarro, Madrid, SpainServicio de Medicina Interna, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, SpainDepartment of Nutrition, Food Science, Physiology and Toxicology, Centre for Nutrition Research, University of Navarra, Pamplona, SpainObjective. To systematically explore genetic polymorphisms associated with the clinical outcomes in SARS-CoV infection in humans. Methods. This comprehensive literature search comprised available English papers published in PubMed/Medline and SCOPUS databases following the PRISMA-P guidelines and PICO/AXIS criteria. Results. Twenty-nine polymorphisms located in 21 genes were identified as associated with SARS-CoV susceptibility/resistance, disease severity, and clinical outcomes predominantly in Asian populations. Thus, genes implicated in key pathophysiological processes such as the mechanisms related to the entry of the virus into the cell and the antiviral immune/inflammatory responses were identified. Conclusions. Although caution must be taken, the results of this systematic review suggest that multiple genetic polymorphisms are associated with SARS-CoV infection features by affecting virus pathogenesis and host immune response, which could have important applications for the study and understanding of genetics in SARS-CoV-2/COVID-19 and for personalized translational clinical practice depending on the population studied and associated environments.http://dx.doi.org/10.1155/2020/6901217 |
| spellingShingle | Omar Ramos-Lopez Lidia Daimiel Ana Ramírez de Molina Diego Martínez-Urbistondo Juan A. Vargas J. Alfredo Martínez Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19 International Journal of Genomics |
| title | Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19 |
| title_full | Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19 |
| title_fullStr | Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19 |
| title_full_unstemmed | Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19 |
| title_short | Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19 |
| title_sort | exploring host genetic polymorphisms involved in sars cov infection outcomes implications for personalized medicine in covid 19 |
| url | http://dx.doi.org/10.1155/2020/6901217 |
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