Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 Diabetes
Background/Aims. This study was designed to identify the clinical characteristics of Korean patients with type 2 diabetes according to metformin use. Methods. This cross-sectional study based on the Korean National Diabetes Program 2 registry used its baseline clinical data collected from seven part...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/9879517 |
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| author | Sang Ouk Chin In Gyoon Ha Sang Youl Rhee Su Jin Jeong Suk Chon Sung Hoon Kim Kyu Jeung Ahn Sei Hyun Baik Yongsoo Park Moon Suk Nam Kwan Woo Lee Jeong Taek Woo |
| author_facet | Sang Ouk Chin In Gyoon Ha Sang Youl Rhee Su Jin Jeong Suk Chon Sung Hoon Kim Kyu Jeung Ahn Sei Hyun Baik Yongsoo Park Moon Suk Nam Kwan Woo Lee Jeong Taek Woo |
| author_sort | Sang Ouk Chin |
| collection | DOAJ |
| description | Background/Aims. This study was designed to identify the clinical characteristics of Korean patients with type 2 diabetes according to metformin use. Methods. This cross-sectional study based on the Korean National Diabetes Program 2 registry used its baseline clinical data collected from seven participating university hospitals in Korea. Patients with no significant changes in their oral hypoglycemic agents and no diabetes-related complications within the year prior to participation were enrolled. Patients’ clinical characteristics according to metformin use were analyzed. Results. Among 858 subjects included in the analyses, 706 were metformin users and 152 were nonmetformin users. Metformin users were significantly younger and had higher and glycated hemoglobin with significantly lower rates of accompanying microvascular complications such as retinopathy, cataracts, overt proteinuria, renal insufficiency, and peripheral neuropathy than nonusers. Meanwhile, there was a significantly lower prevalence of malignancy and depression among metformin users. These associations remained significant in multivariate analyses. The prevalence rate of macrovascular complications was not significantly different between the two groups. Conclusions. There were significant differences with respect to clinical characteristics and comorbidity prevalence according to metformin use among Korean type 2 diabetes patients. Long-term follow-up of these patients is necessary to observe how this difference will affect clinical outcomes for these patients. |
| format | Article |
| id | doaj-art-6a286ad649564cfe860c61f5e8cf2604 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6a286ad649564cfe860c61f5e8cf26042025-02-03T05:51:47ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/98795179879517Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 DiabetesSang Ouk Chin0In Gyoon Ha1Sang Youl Rhee2Su Jin Jeong3Suk Chon4Sung Hoon Kim5Kyu Jeung Ahn6Sei Hyun Baik7Yongsoo Park8Moon Suk Nam9Kwan Woo Lee10Jeong Taek Woo11Department of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of KoreaStatistics Support Department, Kyung Hee University, Medical Center Science Research Institute, Seoul, Republic of KoreaDepartment of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Medicine, Cheil General Hospital and Women’s Healthcare Center, College of Medicine, Dankook University, Yongin, Republic of KoreaDepartment of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Hanyang University, Seoul, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Inha University, Incheon, Republic of KoreaDepartment of Endocrinology and Metabolism, College of Medicine, Ajou University, Suwon, Republic of KoreaDepartment of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of KoreaBackground/Aims. This study was designed to identify the clinical characteristics of Korean patients with type 2 diabetes according to metformin use. Methods. This cross-sectional study based on the Korean National Diabetes Program 2 registry used its baseline clinical data collected from seven participating university hospitals in Korea. Patients with no significant changes in their oral hypoglycemic agents and no diabetes-related complications within the year prior to participation were enrolled. Patients’ clinical characteristics according to metformin use were analyzed. Results. Among 858 subjects included in the analyses, 706 were metformin users and 152 were nonmetformin users. Metformin users were significantly younger and had higher and glycated hemoglobin with significantly lower rates of accompanying microvascular complications such as retinopathy, cataracts, overt proteinuria, renal insufficiency, and peripheral neuropathy than nonusers. Meanwhile, there was a significantly lower prevalence of malignancy and depression among metformin users. These associations remained significant in multivariate analyses. The prevalence rate of macrovascular complications was not significantly different between the two groups. Conclusions. There were significant differences with respect to clinical characteristics and comorbidity prevalence according to metformin use among Korean type 2 diabetes patients. Long-term follow-up of these patients is necessary to observe how this difference will affect clinical outcomes for these patients.http://dx.doi.org/10.1155/2020/9879517 |
| spellingShingle | Sang Ouk Chin In Gyoon Ha Sang Youl Rhee Su Jin Jeong Suk Chon Sung Hoon Kim Kyu Jeung Ahn Sei Hyun Baik Yongsoo Park Moon Suk Nam Kwan Woo Lee Jeong Taek Woo Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 Diabetes International Journal of Endocrinology |
| title | Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 Diabetes |
| title_full | Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 Diabetes |
| title_fullStr | Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 Diabetes |
| title_full_unstemmed | Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 Diabetes |
| title_short | Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 Diabetes |
| title_sort | clinical characteristics and prevalence of comorbidities according to metformin use in korean patients with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2020/9879517 |
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