Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives
The 2-amino-7-methoxypyrimido[4,5-b]quinoline (1) on treatment with bis(methylthio)methylene malononitrile (2) in ethyl alcohol and catalytic amount of TEA gives 3-cyano-4-imino-9-methoxy-2-methythio-4H-pyrimido[2,1-b]pyrimido[4,5-b]quinoline (3). The latter were further reacted with selected N-, O...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/862651 |
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| author | S. P. Vartale N. K. Halikar Y. D. Pawar |
| author_facet | S. P. Vartale N. K. Halikar Y. D. Pawar |
| author_sort | S. P. Vartale |
| collection | DOAJ |
| description | The 2-amino-7-methoxypyrimido[4,5-b]quinoline (1) on treatment with bis(methylthio)methylene malononitrile (2) in ethyl alcohol and catalytic amount of TEA gives 3-cyano-4-imino-9-methoxy-2-methythio-4H-pyrimido[2,1-b]pyrimido[4,5-b]quinoline (3). The latter were further reacted with selected N-, O-, and C-nucleophiles such as aryl amines, hetryl amines, substituted phenols, and compounds containing an active methylene group. |
| format | Article |
| id | doaj-art-6a2269c133c5480da6637ce1cb9d3ac3 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-6a2269c133c5480da6637ce1cb9d3ac32025-02-03T05:44:52ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/862651862651Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted DerivativesS. P. Vartale0N. K. Halikar1Y. D. Pawar2Department of Chemistry, P.G. Research Centre, Yeshwant Mahavidyalaya, Nanded 431602, IndiaDepartment of Chemistry, P.G. Research Centre, Yeshwant Mahavidyalaya, Nanded 431602, IndiaDepartment of Chemistry, P.G. Research Centre, Yeshwant Mahavidyalaya, Nanded 431602, IndiaThe 2-amino-7-methoxypyrimido[4,5-b]quinoline (1) on treatment with bis(methylthio)methylene malononitrile (2) in ethyl alcohol and catalytic amount of TEA gives 3-cyano-4-imino-9-methoxy-2-methythio-4H-pyrimido[2,1-b]pyrimido[4,5-b]quinoline (3). The latter were further reacted with selected N-, O-, and C-nucleophiles such as aryl amines, hetryl amines, substituted phenols, and compounds containing an active methylene group.http://dx.doi.org/10.1155/2013/862651 |
| spellingShingle | S. P. Vartale N. K. Halikar Y. D. Pawar Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives Journal of Chemistry |
| title | Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives |
| title_full | Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives |
| title_fullStr | Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives |
| title_full_unstemmed | Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives |
| title_short | Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives |
| title_sort | synthesis and antimicrobial activity of 3 cyano 4 imino 9 methoxy 4h pyrimido 2 1 b pyrimido 4 5 b quinoline and 2 substituted derivatives |
| url | http://dx.doi.org/10.1155/2013/862651 |
| work_keys_str_mv | AT spvartale synthesisandantimicrobialactivityof3cyano4imino9methoxy4hpyrimido21bpyrimido45bquinolineand2substitutedderivatives AT nkhalikar synthesisandantimicrobialactivityof3cyano4imino9methoxy4hpyrimido21bpyrimido45bquinolineand2substitutedderivatives AT ydpawar synthesisandantimicrobialactivityof3cyano4imino9methoxy4hpyrimido21bpyrimido45bquinolineand2substitutedderivatives |