Amniotic Fluid Stem Cells: Future Perspectives
The existence of stem cells in human amniotic fluid was reported for the first time almost ten years ago. Since this discovery, the knowledge about these cells has increased dramatically. Today, amniotic fluid stem (AFS) cells are widely accepted as a new powerful tool for basic research as well as...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/741810 |
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| _version_ | 1832550003386613760 |
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| author | Margit Rosner Katharina Schipany Bharanidharan Shanmugasundaram Gert Lubec Markus Hengstschläger |
| author_facet | Margit Rosner Katharina Schipany Bharanidharan Shanmugasundaram Gert Lubec Markus Hengstschläger |
| author_sort | Margit Rosner |
| collection | DOAJ |
| description | The existence of stem cells in human amniotic fluid was reported for the first time almost ten years ago. Since this discovery, the knowledge about these cells has increased dramatically. Today, amniotic fluid stem (AFS) cells are widely accepted as a new powerful tool for basic research as well as for the establishment of new stem-cell-based therapy concepts. It is possible to generate monoclonal genomically stable AFS cell lines harboring high proliferative potential without raising ethical issues. Many different groups have demonstrated that AFS cells can be differentiated into all three germ layer lineages, what is of relevance for both, the scientific and therapeutical usage of these cells. Of special importance for the latter is the fact that AFS cells are less tumorigenic than other pluripotent stem cell types. In this paper, we have summarized the current knowledge about this relatively young scientific field. Furthermore, we discuss the relevant future perspectives of this promising area of stem cell research focusing on the next important questions, which need to be answered. |
| format | Article |
| id | doaj-art-6a18c723354a4461b2c926d1db829729 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-6a18c723354a4461b2c926d1db8297292025-02-03T06:08:01ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/741810741810Amniotic Fluid Stem Cells: Future PerspectivesMargit Rosner0Katharina Schipany1Bharanidharan Shanmugasundaram2Gert Lubec3Markus Hengstschläger4Institute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090 Vienna, AustriaInstitute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090 Vienna, AustriaInstitute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090 Vienna, AustriaDepartment of Pediatrics, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, AustriaInstitute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090 Vienna, AustriaThe existence of stem cells in human amniotic fluid was reported for the first time almost ten years ago. Since this discovery, the knowledge about these cells has increased dramatically. Today, amniotic fluid stem (AFS) cells are widely accepted as a new powerful tool for basic research as well as for the establishment of new stem-cell-based therapy concepts. It is possible to generate monoclonal genomically stable AFS cell lines harboring high proliferative potential without raising ethical issues. Many different groups have demonstrated that AFS cells can be differentiated into all three germ layer lineages, what is of relevance for both, the scientific and therapeutical usage of these cells. Of special importance for the latter is the fact that AFS cells are less tumorigenic than other pluripotent stem cell types. In this paper, we have summarized the current knowledge about this relatively young scientific field. Furthermore, we discuss the relevant future perspectives of this promising area of stem cell research focusing on the next important questions, which need to be answered.http://dx.doi.org/10.1155/2012/741810 |
| spellingShingle | Margit Rosner Katharina Schipany Bharanidharan Shanmugasundaram Gert Lubec Markus Hengstschläger Amniotic Fluid Stem Cells: Future Perspectives Stem Cells International |
| title | Amniotic Fluid Stem Cells: Future Perspectives |
| title_full | Amniotic Fluid Stem Cells: Future Perspectives |
| title_fullStr | Amniotic Fluid Stem Cells: Future Perspectives |
| title_full_unstemmed | Amniotic Fluid Stem Cells: Future Perspectives |
| title_short | Amniotic Fluid Stem Cells: Future Perspectives |
| title_sort | amniotic fluid stem cells future perspectives |
| url | http://dx.doi.org/10.1155/2012/741810 |
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