Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets
Abstract Background Epilepsy is a neurological disorder that affects a significant portion of the global population. However, its complexity and the lack of biomarkers hinder the study of its etiology, resulting in a lack of effective treatments to slow down or halt disease development, also called...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-04-01
|
| Series: | EJNMMI Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13550-025-01237-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850181565987946496 |
|---|---|
| author | Nira Hernández-Martín Ignacio Pozo-Cabanell Rubén Fernández de la Rosa Luis García-García Francisca Gómez-Oliver Miguel Ángel Pozo Mirjam Brackhan Pablo Bascuñana |
| author_facet | Nira Hernández-Martín Ignacio Pozo-Cabanell Rubén Fernández de la Rosa Luis García-García Francisca Gómez-Oliver Miguel Ángel Pozo Mirjam Brackhan Pablo Bascuñana |
| author_sort | Nira Hernández-Martín |
| collection | DOAJ |
| description | Abstract Background Epilepsy is a neurological disorder that affects a significant portion of the global population. However, its complexity and the lack of biomarkers hinder the study of its etiology, resulting in a lack of effective treatments to slow down or halt disease development, also called epileptogenesis. Main body Animal models have proven to be a crucial tool for studying epileptogenesis, many exhibiting cellular, molecular, and functional alterations that resemble those found in human patients. This review examines preclinical studies that have utilized positron emission tomography, a non-invasive neuroimaging technique that has demonstrated correlation with the pathological features and behavioral comorbidities of the disease and a high predictive value for the severity of epileptogenesis. Conclusion Positron emission tomography imaging has fostered the knowledge of the mechanisms driving epileptogenesis. This translational technique might be crucial for identifying biomarkers of epilepsy, identifying novel treatment targets and selecting and monitoring patients for potential future therapies. |
| format | Article |
| id | doaj-art-6a0b7ae34017480db2b5ceb2e7df77f9 |
| institution | OA Journals |
| issn | 2191-219X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj-art-6a0b7ae34017480db2b5ceb2e7df77f92025-08-20T02:17:52ZengSpringerOpenEJNMMI Research2191-219X2025-04-0115111810.1186/s13550-025-01237-3Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targetsNira Hernández-Martín0Ignacio Pozo-Cabanell1Rubén Fernández de la Rosa2Luis García-García3Francisca Gómez-Oliver4Miguel Ángel Pozo5Mirjam Brackhan6Pablo Bascuñana7PET Center, Department of Radiology and Biomedical Imaging, Yale School of MedicineCartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de MadridCartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de MadridCartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de MadridCartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de MadridCartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de MadridCartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de MadridCartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de MadridAbstract Background Epilepsy is a neurological disorder that affects a significant portion of the global population. However, its complexity and the lack of biomarkers hinder the study of its etiology, resulting in a lack of effective treatments to slow down or halt disease development, also called epileptogenesis. Main body Animal models have proven to be a crucial tool for studying epileptogenesis, many exhibiting cellular, molecular, and functional alterations that resemble those found in human patients. This review examines preclinical studies that have utilized positron emission tomography, a non-invasive neuroimaging technique that has demonstrated correlation with the pathological features and behavioral comorbidities of the disease and a high predictive value for the severity of epileptogenesis. Conclusion Positron emission tomography imaging has fostered the knowledge of the mechanisms driving epileptogenesis. This translational technique might be crucial for identifying biomarkers of epilepsy, identifying novel treatment targets and selecting and monitoring patients for potential future therapies.https://doi.org/10.1186/s13550-025-01237-3EpilepsyEpileptogenesisPETAnimal modelsBiomarker |
| spellingShingle | Nira Hernández-Martín Ignacio Pozo-Cabanell Rubén Fernández de la Rosa Luis García-García Francisca Gómez-Oliver Miguel Ángel Pozo Mirjam Brackhan Pablo Bascuñana Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets EJNMMI Research Epilepsy Epileptogenesis PET Animal models Biomarker |
| title | Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets |
| title_full | Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets |
| title_fullStr | Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets |
| title_full_unstemmed | Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets |
| title_short | Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets |
| title_sort | preclinical pet imaging in epileptogenesis towards identification of biomarkers and therapeutic targets |
| topic | Epilepsy Epileptogenesis PET Animal models Biomarker |
| url | https://doi.org/10.1186/s13550-025-01237-3 |
| work_keys_str_mv | AT nirahernandezmartin preclinicalpetimaginginepileptogenesistowardsidentificationofbiomarkersandtherapeutictargets AT ignaciopozocabanell preclinicalpetimaginginepileptogenesistowardsidentificationofbiomarkersandtherapeutictargets AT rubenfernandezdelarosa preclinicalpetimaginginepileptogenesistowardsidentificationofbiomarkersandtherapeutictargets AT luisgarciagarcia preclinicalpetimaginginepileptogenesistowardsidentificationofbiomarkersandtherapeutictargets AT franciscagomezoliver preclinicalpetimaginginepileptogenesistowardsidentificationofbiomarkersandtherapeutictargets AT miguelangelpozo preclinicalpetimaginginepileptogenesistowardsidentificationofbiomarkersandtherapeutictargets AT mirjambrackhan preclinicalpetimaginginepileptogenesistowardsidentificationofbiomarkersandtherapeutictargets AT pablobascunana preclinicalpetimaginginepileptogenesistowardsidentificationofbiomarkersandtherapeutictargets |