Evaluation of the hypocholesterolemic efficacy of lyophilized nerium oleander distillate
<b>Aim:</b> The purpose of this study was to assess the effect of administering Nerium oleander distillate on hypercholesterolemic rats' serum biochemical parameters.<p> <b>Materials and Methods:</b> Three equal groups of 30 male Sprague-Dawley rats were formed. No...
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Selcuk University Press
2022-09-01
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1396 |
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| author | Harun Kizilay Ahmet Levent Bas Nuray Yazihan |
| author_facet | Harun Kizilay Ahmet Levent Bas Nuray Yazihan |
| author_sort | Harun Kizilay |
| collection | DOAJ |
| description | <b>Aim:</b> The purpose of this study was to assess the effect of administering
Nerium oleander distillate on hypercholesterolemic rats' serum biochemical
parameters.<p>
<b>Materials and Methods:</b> Three equal groups of 30 male Sprague-Dawley
rats were formed. No application was made for the control group. The second
group received a high cholesterol diet, while the third group received a
high cholesterol diet in addition to lyophilized Nerium oleander distillate by
oral gavage once daily. After three months, blood was drawn after sedation
and they were euthanized. Serum fasting blood glucose, triglyceride, highdensity
lipoprotein, total cholesterol, low-density lipoprotein, alanine
aminotransferase, aspartate aminotransferase, albumin, and total protein
levels, as well as alkaline phosphatase, lactate dehydrogenase, creatinine, and
urea levels, were determined using an autoanalyzer.<p>
<b>Results:</b> Alkaline phosphatase, alanine aminotransferase, aspartate
aminotransferase, cholesterol, glucose, low-density lipoprotein, and
triglyceride levels increased (p < 0.05) in the group fed a high cholesterol diet
compared to the control group, but Nerium oleander treatment decreased the
elevated aspartate aminotransferase, cholesterol, low-density lipoprotein,
and triglyceride (p < 0.05).<p>
<b>Conclusion:</b> To summarize, it can be stated that Nerium oleander distillate has
antihypercholesterolemic and liver-protective properties. |
| format | Article |
| id | doaj-art-69f9f6083ff24c3f841e7e9130a3f444 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-69f9f6083ff24c3f841e7e9130a3f4442025-02-03T11:25:37ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532022-09-013831371421396Evaluation of the hypocholesterolemic efficacy of lyophilized nerium oleander distillateHarun Kizilay0Ahmet Levent Bas1Nuray Yazihan2Selcuk University, Health Science Institute, Department of Pharmacology and Toxicology, Konya, TurkeySelcuk University, Veterinary Faculty, Department of Pharmacology and Toxicology, Konya, TurkeyAnkara University, Medicine Faculty, Department of Pathophysiology, Internal Medicine, Ankara, Turkey<b>Aim:</b> The purpose of this study was to assess the effect of administering Nerium oleander distillate on hypercholesterolemic rats' serum biochemical parameters.<p> <b>Materials and Methods:</b> Three equal groups of 30 male Sprague-Dawley rats were formed. No application was made for the control group. The second group received a high cholesterol diet, while the third group received a high cholesterol diet in addition to lyophilized Nerium oleander distillate by oral gavage once daily. After three months, blood was drawn after sedation and they were euthanized. Serum fasting blood glucose, triglyceride, highdensity lipoprotein, total cholesterol, low-density lipoprotein, alanine aminotransferase, aspartate aminotransferase, albumin, and total protein levels, as well as alkaline phosphatase, lactate dehydrogenase, creatinine, and urea levels, were determined using an autoanalyzer.<p> <b>Results:</b> Alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, cholesterol, glucose, low-density lipoprotein, and triglyceride levels increased (p < 0.05) in the group fed a high cholesterol diet compared to the control group, but Nerium oleander treatment decreased the elevated aspartate aminotransferase, cholesterol, low-density lipoprotein, and triglyceride (p < 0.05).<p> <b>Conclusion:</b> To summarize, it can be stated that Nerium oleander distillate has antihypercholesterolemic and liver-protective properties.http://eurasianjvetsci.org/pdf.php3?id=1396nerium oleanderhypercholesterolemiarat |
| spellingShingle | Harun Kizilay Ahmet Levent Bas Nuray Yazihan Evaluation of the hypocholesterolemic efficacy of lyophilized nerium oleander distillate Eurasian Journal of Veterinary Sciences nerium oleander hypercholesterolemia rat |
| title | Evaluation of the hypocholesterolemic efficacy of lyophilized nerium oleander distillate |
| title_full | Evaluation of the hypocholesterolemic efficacy of lyophilized nerium oleander distillate |
| title_fullStr | Evaluation of the hypocholesterolemic efficacy of lyophilized nerium oleander distillate |
| title_full_unstemmed | Evaluation of the hypocholesterolemic efficacy of lyophilized nerium oleander distillate |
| title_short | Evaluation of the hypocholesterolemic efficacy of lyophilized nerium oleander distillate |
| title_sort | evaluation of the hypocholesterolemic efficacy of lyophilized nerium oleander distillate |
| topic | nerium oleander hypercholesterolemia rat |
| url | http://eurasianjvetsci.org/pdf.php3?id=1396 |
| work_keys_str_mv | AT harunkizilay evaluationofthehypocholesterolemicefficacyoflyophilizedneriumoleanderdistillate AT ahmetleventbas evaluationofthehypocholesterolemicefficacyoflyophilizedneriumoleanderdistillate AT nurayyazihan evaluationofthehypocholesterolemicefficacyoflyophilizedneriumoleanderdistillate |