Evaluation of the hypocholesterolemic efficacy of lyophilized nerium oleander distillate
<b>Aim:</b> The purpose of this study was to assess the effect of administering Nerium oleander distillate on hypercholesterolemic rats' serum biochemical parameters.<p> <b>Materials and Methods:</b> Three equal groups of 30 male Sprague-Dawley rats were formed. No...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2022-09-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1396 |
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| Summary: | <b>Aim:</b> The purpose of this study was to assess the effect of administering
Nerium oleander distillate on hypercholesterolemic rats' serum biochemical
parameters.<p>
<b>Materials and Methods:</b> Three equal groups of 30 male Sprague-Dawley
rats were formed. No application was made for the control group. The second
group received a high cholesterol diet, while the third group received a
high cholesterol diet in addition to lyophilized Nerium oleander distillate by
oral gavage once daily. After three months, blood was drawn after sedation
and they were euthanized. Serum fasting blood glucose, triglyceride, highdensity
lipoprotein, total cholesterol, low-density lipoprotein, alanine
aminotransferase, aspartate aminotransferase, albumin, and total protein
levels, as well as alkaline phosphatase, lactate dehydrogenase, creatinine, and
urea levels, were determined using an autoanalyzer.<p>
<b>Results:</b> Alkaline phosphatase, alanine aminotransferase, aspartate
aminotransferase, cholesterol, glucose, low-density lipoprotein, and
triglyceride levels increased (p < 0.05) in the group fed a high cholesterol diet
compared to the control group, but Nerium oleander treatment decreased the
elevated aspartate aminotransferase, cholesterol, low-density lipoprotein,
and triglyceride (p < 0.05).<p>
<b>Conclusion:</b> To summarize, it can be stated that Nerium oleander distillate has
antihypercholesterolemic and liver-protective properties. |
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| ISSN: | 1309-6958 2146-1953 |