Perioperative Endocrine Therapy for Patients with Cushing's Syndrome Undergoing Retroperitoneal Laparoscopic Adrenalectomy
Objectives. To investigate the efficacy and safety of perioperative endocrine therapy (PET) for patients with Cushing’s syndrome (CS) undergoing retroperitoneal laparoscopic adrenalectomy (RLA). Methods. The novel, simplified PET modality of 82 patients who underwent RLA procedures for CS were studi...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/983965 |
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| author | Xiaobo Cui Lu Yang Jianwei Li Siyuan Bu Qiang Wei Zhenmei An Tianyong Fan |
| author_facet | Xiaobo Cui Lu Yang Jianwei Li Siyuan Bu Qiang Wei Zhenmei An Tianyong Fan |
| author_sort | Xiaobo Cui |
| collection | DOAJ |
| description | Objectives. To investigate the efficacy and safety of perioperative endocrine therapy (PET) for patients with Cushing’s syndrome (CS) undergoing retroperitoneal laparoscopic adrenalectomy (RLA). Methods. The novel, simplified PET modality of 82 patients who underwent RLA procedures for CS were studied. Clinical manifestations were observed for all patients on days 1 and 5 postoperatively, and clinical data, such as blood pressure (BP), levels of serum cortisol, adrenocorticotropin (ACTH), blood glucose, and electrolytes, were acquired and analyzed. Results. Supraphysiological doses of glucocorticoid were administered during the perioperative period, and the dosage was reduced gradually. In all 82 cases, the RLAs were performed successfully without any perioperative complication, such as steroid withdrawal symptoms. The patient’s symptoms and signs were improved quickly and safely during the hospital days. The serum cortisol and potassium levels were rather stable on days 1 and 5 postoperatively, and most were within the normal range. The clinical manifestations, serum levels of cortisol, ACTH, and potassium in most patients restored to normal gradually after several months (mean, 6.7 ± 1.2 months), except for one patient undergoing bilateral adrenalectomy. Conclusions. This perioperative endocrine therapy for patients with Cushing’s syndrome (mainly for adrenocortical adenoma) undergoing retro-laparoscopic adrenalectomy is both effective and safe. |
| format | Article |
| id | doaj-art-69f9e18c7dd14386b2d9049b039e24c2 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-69f9e18c7dd14386b2d9049b039e24c22025-02-03T01:23:59ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/983965983965Perioperative Endocrine Therapy for Patients with Cushing's Syndrome Undergoing Retroperitoneal Laparoscopic AdrenalectomyXiaobo Cui0Lu Yang1Jianwei Li2Siyuan Bu3Qiang Wei4Zhenmei An5Tianyong Fan6Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu 610041, ChinaObjectives. To investigate the efficacy and safety of perioperative endocrine therapy (PET) for patients with Cushing’s syndrome (CS) undergoing retroperitoneal laparoscopic adrenalectomy (RLA). Methods. The novel, simplified PET modality of 82 patients who underwent RLA procedures for CS were studied. Clinical manifestations were observed for all patients on days 1 and 5 postoperatively, and clinical data, such as blood pressure (BP), levels of serum cortisol, adrenocorticotropin (ACTH), blood glucose, and electrolytes, were acquired and analyzed. Results. Supraphysiological doses of glucocorticoid were administered during the perioperative period, and the dosage was reduced gradually. In all 82 cases, the RLAs were performed successfully without any perioperative complication, such as steroid withdrawal symptoms. The patient’s symptoms and signs were improved quickly and safely during the hospital days. The serum cortisol and potassium levels were rather stable on days 1 and 5 postoperatively, and most were within the normal range. The clinical manifestations, serum levels of cortisol, ACTH, and potassium in most patients restored to normal gradually after several months (mean, 6.7 ± 1.2 months), except for one patient undergoing bilateral adrenalectomy. Conclusions. This perioperative endocrine therapy for patients with Cushing’s syndrome (mainly for adrenocortical adenoma) undergoing retro-laparoscopic adrenalectomy is both effective and safe.http://dx.doi.org/10.1155/2012/983965 |
| spellingShingle | Xiaobo Cui Lu Yang Jianwei Li Siyuan Bu Qiang Wei Zhenmei An Tianyong Fan Perioperative Endocrine Therapy for Patients with Cushing's Syndrome Undergoing Retroperitoneal Laparoscopic Adrenalectomy International Journal of Endocrinology |
| title | Perioperative Endocrine Therapy for Patients with Cushing's Syndrome Undergoing Retroperitoneal Laparoscopic Adrenalectomy |
| title_full | Perioperative Endocrine Therapy for Patients with Cushing's Syndrome Undergoing Retroperitoneal Laparoscopic Adrenalectomy |
| title_fullStr | Perioperative Endocrine Therapy for Patients with Cushing's Syndrome Undergoing Retroperitoneal Laparoscopic Adrenalectomy |
| title_full_unstemmed | Perioperative Endocrine Therapy for Patients with Cushing's Syndrome Undergoing Retroperitoneal Laparoscopic Adrenalectomy |
| title_short | Perioperative Endocrine Therapy for Patients with Cushing's Syndrome Undergoing Retroperitoneal Laparoscopic Adrenalectomy |
| title_sort | perioperative endocrine therapy for patients with cushing s syndrome undergoing retroperitoneal laparoscopic adrenalectomy |
| url | http://dx.doi.org/10.1155/2012/983965 |
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