The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic stroke

The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic stroke

Gut microbiota disturbances can elevate the risk of stroke by contributing to cerebrovascular events. Particularly, the gut tryptophan (TRP) metabolite is an essential mediator of the gut-brain axis. This review highlights the role of TRP metabolism in stroke, the influence of intestinal microbiomes...

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Bibliographic Details
Main Authors: Na Qin, Xiaodi Xie, Rong Deng, Shiman Gao, Ting Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
tryptophan metabolites
gut microbiota
microbiota-gut-brain axis
ischemic stroke
kynurenine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1578018/full
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