Preoperative neck ultrasound combined with pathological data can significantly impact the outcome of medullary thyroid carcinoma
The diagnosis of medullary thyroid carcinoma (MTC) is challenging since the accuracy of ultrasound (US) and fine-needle aspiration cytology are suboptimal. As a result, MTC has a generally poor prognosis. The aim of this study was to analyze whether perioperative data can modify the risk of relapse...
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The Japan Endocrine Society
2023-11-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/70/11/70_EJ23-0273/_html/-char/en |
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| author | Maurilio Deandrea Tommaso Piticchio Alberto Mormile Francesca Retta Giovanni Canale Alessandra Caracciolo Lorenzo Daniele Pierpaolo Trimboli |
| author_facet | Maurilio Deandrea Tommaso Piticchio Alberto Mormile Francesca Retta Giovanni Canale Alessandra Caracciolo Lorenzo Daniele Pierpaolo Trimboli |
| author_sort | Maurilio Deandrea |
| collection | DOAJ |
| description | The diagnosis of medullary thyroid carcinoma (MTC) is challenging since the accuracy of ultrasound (US) and fine-needle aspiration cytology are suboptimal. As a result, MTC has a generally poor prognosis. The aim of this study was to analyze whether perioperative data can modify the risk of relapse in these patients. The institutional database of Turin Mauriziano Hospital was searched to extract records of MTCs diagnosed between 2000 and 2021. Kaplan-Meier curves and Cox and logistic regression analyses were performed, and the hazard ratio (HR) was calculated. Seventy-three MTC patients (median age 58 yr) were found. Disease-free survival was significantly different according to staging (HR: 9.12; p = 0.037), capsular status (HR: 5.49; p = 0.02), and neck US (HR: 9.19; p = 0.04). In the logistic regression analysis, CEA level (β: –0.01; p = 0.043), histological multifocality (OR: 7.4; p = 0.034), and metastatic lymph nodes at histology (β: –0.13; p = 0.006) were significantly associated with structural recurrence. Two logistic multivariate models best explained the variance in recurrence: 1) neck US presentation plus histological multifocality (AIC: 27; r2: 0.37; x2: 12.4; p = 0.002) and 2) number of neck metastases plus capsular invasion (AIC: 26; r2: 0.40; x2: 13.7; p = 0.001). Pathological data are associated with MTC prognosis. Preoperative neck US can significantly help to predict MTC outcome. |
| format | Article |
| id | doaj-art-69ef2a80a56849408360a19af946e247 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-69ef2a80a56849408360a19af946e2472025-01-22T06:23:18ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402023-11-0170111061106710.1507/endocrj.EJ23-0273endocrjPreoperative neck ultrasound combined with pathological data can significantly impact the outcome of medullary thyroid carcinomaMaurilio Deandrea0Tommaso Piticchio1Alberto Mormile2Francesca Retta3Giovanni Canale4Alessandra Caracciolo5Lorenzo Daniele6Pierpaolo Trimboli7Endocrinology, Diabetes and Metabolism Department and Center for Thyroid Diseases, Ordine Mauriziano Hospital, Turin 10128, ItalyEndocrinology and Diabetes Center, Italian Hospital, Ente Ospedaliero Cantonale (EOC), Viganello 6962, SwitzerlandEndocrinology, Diabetes and Metabolism Department and Center for Thyroid Diseases, Ordine Mauriziano Hospital, Turin 10128, ItalyEndocrinology, Diabetes and Metabolism Department and Center for Thyroid Diseases, Ordine Mauriziano Hospital, Turin 10128, ItalyOtorhinolaryngology Department and Thyroid and Parathyroid Surgery Unit, Ordine Mauriziano Hospital, Turin 10128, ItalyOtorhinolaryngology Department and Thyroid and Parathyroid Surgery Unit, Ordine Mauriziano Hospital, Turin 10128, ItalyPathology Unit, Ordine Mauriziano Hospital, Turin 10128, ItalyEndocrinology and Diabetes Center, Italian Hospital, Ente Ospedaliero Cantonale (EOC), Viganello 6962, SwitzerlandThe diagnosis of medullary thyroid carcinoma (MTC) is challenging since the accuracy of ultrasound (US) and fine-needle aspiration cytology are suboptimal. As a result, MTC has a generally poor prognosis. The aim of this study was to analyze whether perioperative data can modify the risk of relapse in these patients. The institutional database of Turin Mauriziano Hospital was searched to extract records of MTCs diagnosed between 2000 and 2021. Kaplan-Meier curves and Cox and logistic regression analyses were performed, and the hazard ratio (HR) was calculated. Seventy-three MTC patients (median age 58 yr) were found. Disease-free survival was significantly different according to staging (HR: 9.12; p = 0.037), capsular status (HR: 5.49; p = 0.02), and neck US (HR: 9.19; p = 0.04). In the logistic regression analysis, CEA level (β: –0.01; p = 0.043), histological multifocality (OR: 7.4; p = 0.034), and metastatic lymph nodes at histology (β: –0.13; p = 0.006) were significantly associated with structural recurrence. Two logistic multivariate models best explained the variance in recurrence: 1) neck US presentation plus histological multifocality (AIC: 27; r2: 0.37; x2: 12.4; p = 0.002) and 2) number of neck metastases plus capsular invasion (AIC: 26; r2: 0.40; x2: 13.7; p = 0.001). Pathological data are associated with MTC prognosis. Preoperative neck US can significantly help to predict MTC outcome.https://www.jstage.jst.go.jp/article/endocrj/70/11/70_EJ23-0273/_html/-char/enneck ultrasound (us)medullary thyroid cancer (mtc)disease-free survival (dfs)prognosispathological data |
| spellingShingle | Maurilio Deandrea Tommaso Piticchio Alberto Mormile Francesca Retta Giovanni Canale Alessandra Caracciolo Lorenzo Daniele Pierpaolo Trimboli Preoperative neck ultrasound combined with pathological data can significantly impact the outcome of medullary thyroid carcinoma Endocrine Journal neck ultrasound (us) medullary thyroid cancer (mtc) disease-free survival (dfs) prognosis pathological data |
| title | Preoperative neck ultrasound combined with pathological data can significantly impact the outcome of medullary thyroid carcinoma |
| title_full | Preoperative neck ultrasound combined with pathological data can significantly impact the outcome of medullary thyroid carcinoma |
| title_fullStr | Preoperative neck ultrasound combined with pathological data can significantly impact the outcome of medullary thyroid carcinoma |
| title_full_unstemmed | Preoperative neck ultrasound combined with pathological data can significantly impact the outcome of medullary thyroid carcinoma |
| title_short | Preoperative neck ultrasound combined with pathological data can significantly impact the outcome of medullary thyroid carcinoma |
| title_sort | preoperative neck ultrasound combined with pathological data can significantly impact the outcome of medullary thyroid carcinoma |
| topic | neck ultrasound (us) medullary thyroid cancer (mtc) disease-free survival (dfs) prognosis pathological data |
| url | https://www.jstage.jst.go.jp/article/endocrj/70/11/70_EJ23-0273/_html/-char/en |
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