Evaluation of Lipid Profile in Patients with Non-diabetic Chronic Kidney Disease
Background Chronic kidney disease (CKD) is a global health concern associated with dyslipidemia, which contributes significantly to disease progression and cardiovascular risk. Understanding lipid profile alterations in non-diabetic CKD patients is crucial for improving management strategies. Object...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-07-01
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| Series: | Assam Journal of Internal Medicine |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ajoim.ajoim_22_24 |
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| Summary: | Background
Chronic kidney disease (CKD) is a global health concern associated with dyslipidemia, which contributes significantly to disease progression and cardiovascular risk. Understanding lipid profile alterations in non-diabetic CKD patients is crucial for improving management strategies.
Objectives
This study aimed to analyze lipid profiles in non-diabetic CKD patients and explore the association between lipid abnormalities and CKD severity.Materials and Methods
A cross-sectional study involving 80 non-diabetic CKD patients was conducted at Tezpur Medical College and Hospital. Fasting lipid profiles, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), were measured. GFR was estimated using the CKD Epidemiology Collaboration (CKD-EPI) equation. Correlations between lipid parameters and CKD stages were assessed statistically.
Results and Discussion
Dyslipidemia was observed in 65% of participants and was more prevalent in advanced CKD stages. A significant decline in HDL-C levels was observed with disease progression (P = 0.029). TG levels increased with advancing CKD but were not statistically significant (P = 0.343). No significant variation was noted in TC or LDL-C levels across stages. Significant correlations included a positive relationship between GFR and HDL-C (P < 0.05) and a negative relationship between TG and HDL-C (P < 0.01). These findings suggest that lipid abnormalities in CKD are influenced by insulin resistance, oxidative stress, and uremic toxins, contributing to cardiovascular risk.
Conclusion
This study underscores the high prevalence of dyslipidemia in non-diabetic CKD patients, with HDL-C serving as a potential marker of disease severity. Regular lipid monitoring and tailored interventions are essential to manage cardiovascular risk effectively. |
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| ISSN: | 2278-8239 2773-0166 |