The Association between Neutrophil-to-Lymphocyte Ratio and Glycemic Control in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Background. Glycated hemoglobin (HbA1c) is a commonly used clinical marker to monitor the control of type 2 diabetes mellitus patients (T2DM). However, it is unable to identify the ongoing inflammatory changes in the body. These factors could be easily identified and monitored by the neutrophil-to-l...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2023/3117396 |
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| author | Tiruneh Adane Mulugeta Melku Yilkal Belete Worku Alebachew Fasil Melak Aynalem Amanuel Kelem Solomon Getawa |
| author_facet | Tiruneh Adane Mulugeta Melku Yilkal Belete Worku Alebachew Fasil Melak Aynalem Amanuel Kelem Solomon Getawa |
| author_sort | Tiruneh Adane |
| collection | DOAJ |
| description | Background. Glycated hemoglobin (HbA1c) is a commonly used clinical marker to monitor the control of type 2 diabetes mellitus patients (T2DM). However, it is unable to identify the ongoing inflammatory changes in the body. These factors could be easily identified and monitored by the neutrophil-to-lymphocyte ratio (NLR). Therefore, this study is aimed at investigating the relationship between NLR and glycemic control in T2DM. Method. A comprehensive search of eligible studies was performed in various databases published until July 2021. A random effect model was used to estimate the standardized mean difference (SMD). A metaregression, subgroup, and sensitivity analysis were conducted to search for potential sources of heterogeneity. Result. A total of 13 studies were included in this study. Accordingly, the SMD of the NLR values between the poor and good glycemic control groups was 0.79 (95% CI, 0.46-1.12). Our study also showed that high NLR was significantly associated with poor glycemic control in T2DM patients (OR=1.50, 95% CI: 1.30-1.93). Conclusion. The results of this study suggest an association between high NLR values and an elevated HbA1C in T2DM patients. Therefore, NLR should be considered a marker of glycemic control in addition to HbA1c in T2DM patients. |
| format | Article |
| id | doaj-art-69dbf2dd3ffa42d6b6c8847d8926d7fa |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-69dbf2dd3ffa42d6b6c8847d8926d7fa2025-02-03T06:47:22ZengWileyJournal of Diabetes Research2314-67532023-01-01202310.1155/2023/3117396The Association between Neutrophil-to-Lymphocyte Ratio and Glycemic Control in Type 2 Diabetes Mellitus: A Systematic Review and Meta-AnalysisTiruneh Adane0Mulugeta Melku1Yilkal Belete Worku2Alebachew Fasil3Melak Aynalem4Amanuel Kelem5Solomon Getawa6Department of Hematology and ImmunohematologyDepartment of Hematology and ImmunohematologyDepartment of Internal MedicineDepartment of Clinical ChemistryDepartment of Hematology and ImmunohematologyDepartment of Medical Laboratory SciencesDepartment of Hematology and ImmunohematologyBackground. Glycated hemoglobin (HbA1c) is a commonly used clinical marker to monitor the control of type 2 diabetes mellitus patients (T2DM). However, it is unable to identify the ongoing inflammatory changes in the body. These factors could be easily identified and monitored by the neutrophil-to-lymphocyte ratio (NLR). Therefore, this study is aimed at investigating the relationship between NLR and glycemic control in T2DM. Method. A comprehensive search of eligible studies was performed in various databases published until July 2021. A random effect model was used to estimate the standardized mean difference (SMD). A metaregression, subgroup, and sensitivity analysis were conducted to search for potential sources of heterogeneity. Result. A total of 13 studies were included in this study. Accordingly, the SMD of the NLR values between the poor and good glycemic control groups was 0.79 (95% CI, 0.46-1.12). Our study also showed that high NLR was significantly associated with poor glycemic control in T2DM patients (OR=1.50, 95% CI: 1.30-1.93). Conclusion. The results of this study suggest an association between high NLR values and an elevated HbA1C in T2DM patients. Therefore, NLR should be considered a marker of glycemic control in addition to HbA1c in T2DM patients.http://dx.doi.org/10.1155/2023/3117396 |
| spellingShingle | Tiruneh Adane Mulugeta Melku Yilkal Belete Worku Alebachew Fasil Melak Aynalem Amanuel Kelem Solomon Getawa The Association between Neutrophil-to-Lymphocyte Ratio and Glycemic Control in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis Journal of Diabetes Research |
| title | The Association between Neutrophil-to-Lymphocyte Ratio and Glycemic Control in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_full | The Association between Neutrophil-to-Lymphocyte Ratio and Glycemic Control in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_fullStr | The Association between Neutrophil-to-Lymphocyte Ratio and Glycemic Control in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Association between Neutrophil-to-Lymphocyte Ratio and Glycemic Control in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_short | The Association between Neutrophil-to-Lymphocyte Ratio and Glycemic Control in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_sort | association between neutrophil to lymphocyte ratio and glycemic control in type 2 diabetes mellitus a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2023/3117396 |
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