Evidence for anomalous network connectivity during working memory encoding in schizophrenia: an ICA based analysis.
<h4>Background</h4>Numerous neuroimaging studies report abnormal regional brain activity during working memory performance in schizophrenia, but few have examined brain network integration as determined by "functional connectivity" analyses.<h4>Methodology/principal findi...
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Public Library of Science (PLoS)
2009-11-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007911&type=printable |
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| author | Shashwath A Meda Michael C Stevens Bradley S Folley Vince D Calhoun Godfrey D Pearlson |
| author_facet | Shashwath A Meda Michael C Stevens Bradley S Folley Vince D Calhoun Godfrey D Pearlson |
| author_sort | Shashwath A Meda |
| collection | DOAJ |
| description | <h4>Background</h4>Numerous neuroimaging studies report abnormal regional brain activity during working memory performance in schizophrenia, but few have examined brain network integration as determined by "functional connectivity" analyses.<h4>Methodology/principal findings</h4>We used independent component analysis (ICA) to identify and characterize dysfunctional spatiotemporal networks in schizophrenia engaged during the different stages (encoding and recognition) of a Sternberg working memory fMRI paradigm. 37 chronic schizophrenia and 54 healthy age/gender-matched participants performed a modified Sternberg Item Recognition fMRI task. Time series images preprocessed with SPM2 were analyzed using ICA. Schizophrenia patients showed relatively less engagement of several distinct "normal" encoding-related working memory networks compared to controls. These encoding networks comprised 1) left posterior parietal-left dorsal/ventrolateral prefrontal cortex, cingulate, basal ganglia, 2) right posterior parietal, right dorsolateral prefrontal cortex and 3) default mode network. In addition, the left fronto-parietal network demonstrated a load-dependent functional response during encoding. Network engagement that differed between groups during recognition comprised the posterior cingulate, cuneus and hippocampus/parahippocampus. As expected, working memory task accuracy differed between groups (p<0.0001) and was associated with degree of network engagement. Functional connectivity within all three encoding-associated functional networks correlated significantly with task accuracy, which further underscores the relevance of abnormal network integration to well-described schizophrenia working memory impairment. No network was significantly associated with task accuracy during the recognition phase.<h4>Conclusions/significance</h4>This study extends the results of numerous previous schizophrenia studies that identified isolated dysfunctional brain regions by providing evidence of disrupted schizophrenia functional connectivity using ICA within widely-distributed neural networks engaged for working memory cognition. |
| format | Article |
| id | doaj-art-69d4eab0f7d44cdcacd32ebed695c854 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2009-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-69d4eab0f7d44cdcacd32ebed695c8542025-08-20T03:19:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-11-01411e791110.1371/journal.pone.0007911Evidence for anomalous network connectivity during working memory encoding in schizophrenia: an ICA based analysis.Shashwath A MedaMichael C StevensBradley S FolleyVince D CalhounGodfrey D Pearlson<h4>Background</h4>Numerous neuroimaging studies report abnormal regional brain activity during working memory performance in schizophrenia, but few have examined brain network integration as determined by "functional connectivity" analyses.<h4>Methodology/principal findings</h4>We used independent component analysis (ICA) to identify and characterize dysfunctional spatiotemporal networks in schizophrenia engaged during the different stages (encoding and recognition) of a Sternberg working memory fMRI paradigm. 37 chronic schizophrenia and 54 healthy age/gender-matched participants performed a modified Sternberg Item Recognition fMRI task. Time series images preprocessed with SPM2 were analyzed using ICA. Schizophrenia patients showed relatively less engagement of several distinct "normal" encoding-related working memory networks compared to controls. These encoding networks comprised 1) left posterior parietal-left dorsal/ventrolateral prefrontal cortex, cingulate, basal ganglia, 2) right posterior parietal, right dorsolateral prefrontal cortex and 3) default mode network. In addition, the left fronto-parietal network demonstrated a load-dependent functional response during encoding. Network engagement that differed between groups during recognition comprised the posterior cingulate, cuneus and hippocampus/parahippocampus. As expected, working memory task accuracy differed between groups (p<0.0001) and was associated with degree of network engagement. Functional connectivity within all three encoding-associated functional networks correlated significantly with task accuracy, which further underscores the relevance of abnormal network integration to well-described schizophrenia working memory impairment. No network was significantly associated with task accuracy during the recognition phase.<h4>Conclusions/significance</h4>This study extends the results of numerous previous schizophrenia studies that identified isolated dysfunctional brain regions by providing evidence of disrupted schizophrenia functional connectivity using ICA within widely-distributed neural networks engaged for working memory cognition.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007911&type=printable |
| spellingShingle | Shashwath A Meda Michael C Stevens Bradley S Folley Vince D Calhoun Godfrey D Pearlson Evidence for anomalous network connectivity during working memory encoding in schizophrenia: an ICA based analysis. PLoS ONE |
| title | Evidence for anomalous network connectivity during working memory encoding in schizophrenia: an ICA based analysis. |
| title_full | Evidence for anomalous network connectivity during working memory encoding in schizophrenia: an ICA based analysis. |
| title_fullStr | Evidence for anomalous network connectivity during working memory encoding in schizophrenia: an ICA based analysis. |
| title_full_unstemmed | Evidence for anomalous network connectivity during working memory encoding in schizophrenia: an ICA based analysis. |
| title_short | Evidence for anomalous network connectivity during working memory encoding in schizophrenia: an ICA based analysis. |
| title_sort | evidence for anomalous network connectivity during working memory encoding in schizophrenia an ica based analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007911&type=printable |
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