Exacerbation of Ulcerative Colitis following Administration of 5-ASA Enemas

A 33-year-old female with a 15 year history of ulcerative colitis presented with worsening diarrhea following colectomy and ileorectal anastomosis six months previously. Following administration of 5-ASA enemas (Salofalk). the patient developed abdominal cramps. nausea and vomiting. and severe diarr...

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Main Authors: Barbara A. Young, Robin S. McLeod, Zane Cohen
Format: Article
Language:English
Published: Wiley 1989-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/1989/461926
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author Barbara A. Young
Robin S. McLeod
Zane Cohen
author_facet Barbara A. Young
Robin S. McLeod
Zane Cohen
author_sort Barbara A. Young
collection DOAJ
description A 33-year-old female with a 15 year history of ulcerative colitis presented with worsening diarrhea following colectomy and ileorectal anastomosis six months previously. Following administration of 5-ASA enemas (Salofalk). the patient developed abdominal cramps. nausea and vomiting. and severe diarrhea resulting in hypotension. Symptoms abated quickly when the 5-ASA enemas, were discontinued. Although diarrhea and abdominal cramps have been described previously as side effects of oral sulfasalazine. oral 5-ASA and sulfasalazine enemas, this is the first report of these symptoms occurring following administration of 5-ASA enemas.
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issn 0835-7900
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series Canadian Journal of Gastroenterology
spelling doaj-art-69cfff5f1eaf495b8b6be2fc4a6611df2025-02-03T01:29:11ZengWileyCanadian Journal of Gastroenterology0835-79001989-01-0132505210.1155/1989/461926Exacerbation of Ulcerative Colitis following Administration of 5-ASA EnemasBarbara A. Young0Robin S. McLeod1Zane Cohen2Division of General Surgery and Departments of Surgery and Pharmacy, Toronto General Hospital, University of Toronto, Toronto, Ontario, CanadaDivision of General Surgery and Departments of Surgery and Pharmacy, Toronto General Hospital, University of Toronto, Toronto, Ontario, CanadaDivision of General Surgery and Departments of Surgery and Pharmacy, Toronto General Hospital, University of Toronto, Toronto, Ontario, CanadaA 33-year-old female with a 15 year history of ulcerative colitis presented with worsening diarrhea following colectomy and ileorectal anastomosis six months previously. Following administration of 5-ASA enemas (Salofalk). the patient developed abdominal cramps. nausea and vomiting. and severe diarrhea resulting in hypotension. Symptoms abated quickly when the 5-ASA enemas, were discontinued. Although diarrhea and abdominal cramps have been described previously as side effects of oral sulfasalazine. oral 5-ASA and sulfasalazine enemas, this is the first report of these symptoms occurring following administration of 5-ASA enemas.http://dx.doi.org/10.1155/1989/461926
spellingShingle Barbara A. Young
Robin S. McLeod
Zane Cohen
Exacerbation of Ulcerative Colitis following Administration of 5-ASA Enemas
Canadian Journal of Gastroenterology
title Exacerbation of Ulcerative Colitis following Administration of 5-ASA Enemas
title_full Exacerbation of Ulcerative Colitis following Administration of 5-ASA Enemas
title_fullStr Exacerbation of Ulcerative Colitis following Administration of 5-ASA Enemas
title_full_unstemmed Exacerbation of Ulcerative Colitis following Administration of 5-ASA Enemas
title_short Exacerbation of Ulcerative Colitis following Administration of 5-ASA Enemas
title_sort exacerbation of ulcerative colitis following administration of 5 asa enemas
url http://dx.doi.org/10.1155/1989/461926
work_keys_str_mv AT barbaraayoung exacerbationofulcerativecolitisfollowingadministrationof5asaenemas
AT robinsmcleod exacerbationofulcerativecolitisfollowingadministrationof5asaenemas
AT zanecohen exacerbationofulcerativecolitisfollowingadministrationof5asaenemas