LCN2 induces neuronal loss and facilitates sepsis-associated cognitive impairments

Abstract Sepsis-associated encephalopathy (SAE) is a severe neurological syndrome marked by widespread brain dysfunctions due to sepsis. Despite increasing data supporting the hypothesis of neuronal damage, the exact mechanism of sepsis-related cognitive disorders and therapeutic strategies remain u...

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Bibliographic Details
Main Authors: Cuiping Guo, Wensheng Li, Yi Liu, Abdoul Razak Mahaman Yacoubou, Jianzhi Wang, Rong Liu, Shusheng Li, Xiaochuan Wang
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07469-4
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