Prevalence and Risk Factors for Minor Hallucinations in Patients with Parkinson’s Disease
Purpose. As the most frequent and earliest type of psychotic phenomenon in Parkinson’s disease (PD), minor hallucination (MH) can occur before the onset of motor symptoms. This sensation may be an early predictor of severe psychotic and cognitive states and is often overlooked in clinics. This study...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2021/3469706 |
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| author | Min Zhong Ruxin Gu Sha Zhu Yu Bai Zhuang Wu Xu Jiang Bo Shen Jun Zhu Yang Pan Jun Yan Li Zhang |
| author_facet | Min Zhong Ruxin Gu Sha Zhu Yu Bai Zhuang Wu Xu Jiang Bo Shen Jun Zhu Yang Pan Jun Yan Li Zhang |
| author_sort | Min Zhong |
| collection | DOAJ |
| description | Purpose. As the most frequent and earliest type of psychotic phenomenon in Parkinson’s disease (PD), minor hallucination (MH) can occur before the onset of motor symptoms. This sensation may be an early predictor of severe psychotic and cognitive states and is often overlooked in clinics. This study was aimed at providing a comprehensive and in-depth understanding of MHs. Patients and Methods. Demographic information was obtained from 262 patients with PD, and a series of clinical assessment questionnaires were provided. According to the result of the Movement Disorders Society Unified Parkinson’s Disease Rating Scale Part I, the patients were classified into the MH and nonhallucination (NH) groups. Results. MHs were the most common psychotic symptom with 38.9% prevalence. The most frequent MH was visual illusion, especially object misidentification. Three minor phenomena were somewhat consistent in terms of external factors, temporal factors, and content. Disease duration, daily levodopa equivalent dose, and percentage of levodopa and dopamine-receptor agonist use were remarkably greater in the MH group than in the NH group. After covariate control, the MH group had worse life quality and more severe nonmotor symptoms, including poor sleep quality and rapid eye movement sleep behavior disorder (RBD), than the NH group. The binary logistic regression model showed that RBD, sleep quality, and health-related life quality were associated with MHs. Conclusion. A high prevalence of MHs was observed in patients with PD. Further studies are needed to confirm and expand the identified clinical factors related to MH, which have potential prognostic and therapeutic implication. |
| format | Article |
| id | doaj-art-69c9efa108d84f68b3d81ba366018747 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-69c9efa108d84f68b3d81ba3660187472025-02-03T06:12:00ZengWileyBehavioural Neurology0953-41801875-85842021-01-01202110.1155/2021/34697063469706Prevalence and Risk Factors for Minor Hallucinations in Patients with Parkinson’s DiseaseMin Zhong0Ruxin Gu1Sha Zhu2Yu Bai3Zhuang Wu4Xu Jiang5Bo Shen6Jun Zhu7Yang Pan8Jun Yan9Li Zhang10Department of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Biological Sciences, University of Toronto Scarborough, CanadaDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaPurpose. As the most frequent and earliest type of psychotic phenomenon in Parkinson’s disease (PD), minor hallucination (MH) can occur before the onset of motor symptoms. This sensation may be an early predictor of severe psychotic and cognitive states and is often overlooked in clinics. This study was aimed at providing a comprehensive and in-depth understanding of MHs. Patients and Methods. Demographic information was obtained from 262 patients with PD, and a series of clinical assessment questionnaires were provided. According to the result of the Movement Disorders Society Unified Parkinson’s Disease Rating Scale Part I, the patients were classified into the MH and nonhallucination (NH) groups. Results. MHs were the most common psychotic symptom with 38.9% prevalence. The most frequent MH was visual illusion, especially object misidentification. Three minor phenomena were somewhat consistent in terms of external factors, temporal factors, and content. Disease duration, daily levodopa equivalent dose, and percentage of levodopa and dopamine-receptor agonist use were remarkably greater in the MH group than in the NH group. After covariate control, the MH group had worse life quality and more severe nonmotor symptoms, including poor sleep quality and rapid eye movement sleep behavior disorder (RBD), than the NH group. The binary logistic regression model showed that RBD, sleep quality, and health-related life quality were associated with MHs. Conclusion. A high prevalence of MHs was observed in patients with PD. Further studies are needed to confirm and expand the identified clinical factors related to MH, which have potential prognostic and therapeutic implication.http://dx.doi.org/10.1155/2021/3469706 |
| spellingShingle | Min Zhong Ruxin Gu Sha Zhu Yu Bai Zhuang Wu Xu Jiang Bo Shen Jun Zhu Yang Pan Jun Yan Li Zhang Prevalence and Risk Factors for Minor Hallucinations in Patients with Parkinson’s Disease Behavioural Neurology |
| title | Prevalence and Risk Factors for Minor Hallucinations in Patients with Parkinson’s Disease |
| title_full | Prevalence and Risk Factors for Minor Hallucinations in Patients with Parkinson’s Disease |
| title_fullStr | Prevalence and Risk Factors for Minor Hallucinations in Patients with Parkinson’s Disease |
| title_full_unstemmed | Prevalence and Risk Factors for Minor Hallucinations in Patients with Parkinson’s Disease |
| title_short | Prevalence and Risk Factors for Minor Hallucinations in Patients with Parkinson’s Disease |
| title_sort | prevalence and risk factors for minor hallucinations in patients with parkinson s disease |
| url | http://dx.doi.org/10.1155/2021/3469706 |
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