The Effect of Virtual Reality on Motor Anticipation and Hand Function in Patients with Subacute Stroke: A Randomized Trial on Movement-Related Potential
Background. Impaired cognitive ability to anticipate the required control for an upcoming task in patients with stroke may affect rehabilitation outcome. The cortical excitability of task-related motor anticipation for upper limb movement induced by virtual reality (VR) training remains unclear. Aim...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2022/7399995 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564059112734720 |
|---|---|
| author | Ling Chen Yi Chen Wen Bin Fu Dong Feng Huang Wai Leung Ambrose Lo |
| author_facet | Ling Chen Yi Chen Wen Bin Fu Dong Feng Huang Wai Leung Ambrose Lo |
| author_sort | Ling Chen |
| collection | DOAJ |
| description | Background. Impaired cognitive ability to anticipate the required control for an upcoming task in patients with stroke may affect rehabilitation outcome. The cortical excitability of task-related motor anticipation for upper limb movement induced by virtual reality (VR) training remains unclear. Aims. To investigate the effect of VR training on the cortical excitability of motor anticipation when executing upper limb movement in patients with subacute stroke. Methods. A total of thirty-six stroke survivors with upper limb hemiparesis resulting from the first occurrence of stroke within 1 to 3 months were recruited. Participants were randomly allocated to the VR intervention group or conventional therapy group. Event-related potentials (ERPs) and electromyography (EMG) were used to simultaneously record the cortical excitability and muscle activities during palmar grasp motion. Outcome measures of the contingent negative variation (CNV) latency and amplitude, EMG reaction time, Upper Limb Fugl-Meyer Assessment (UL-FMA), Action Research Arm Test (ARAT), and National Institutes of Health Stroke Scale (NIHSS) were recorded pre- and postintervention. The between-group difference was analysed by mixed model ANOVA. Results. The EMG onset time of the paretic hand in the VR group was earlier than that observed in the control group (t=2.174, p=0.039) postintervention. CNV latency reduction postintervention was larger in the VR group than in the control group (t=2.411, p=0.021) during paretic hand movement. The reduction in CNV amplitude in the VR group was larger in the VR group than in the control group (p<0.001 for all electrodes except for C3) when executing paretic hand movement. ARAT and UL-FMA scores were significantly higher in the VR group than in the control group (p=0.019 and p=0.037, respectively) postintervention. No significant difference in the reduction in NIHSS was found between the VR and control groups (p=0.072). Conclusions. VR intervention is superior to conventional therapy to improve the cognitive neural process of motor anticipation and reduce the excessive compensatory activation of the contralesional hemisphere. The improvements observed in the cognitive neural process corroborated with the improvements in hand function. |
| format | Article |
| id | doaj-art-69c7bb63580b44ffbeda36bd411be23c |
| institution | Kabale University |
| issn | 1687-5443 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-69c7bb63580b44ffbeda36bd411be23c2025-02-03T01:11:55ZengWileyNeural Plasticity1687-54432022-01-01202210.1155/2022/7399995The Effect of Virtual Reality on Motor Anticipation and Hand Function in Patients with Subacute Stroke: A Randomized Trial on Movement-Related PotentialLing Chen0Yi Chen1Wen Bin Fu2Dong Feng Huang3Wai Leung Ambrose Lo4Department of Acupuncture and MoxibustionGuangzhou University of Chinese MedicineDepartment of Acupuncture and MoxibustionDepartment of RehabilitationDepartment of RehabilitationBackground. Impaired cognitive ability to anticipate the required control for an upcoming task in patients with stroke may affect rehabilitation outcome. The cortical excitability of task-related motor anticipation for upper limb movement induced by virtual reality (VR) training remains unclear. Aims. To investigate the effect of VR training on the cortical excitability of motor anticipation when executing upper limb movement in patients with subacute stroke. Methods. A total of thirty-six stroke survivors with upper limb hemiparesis resulting from the first occurrence of stroke within 1 to 3 months were recruited. Participants were randomly allocated to the VR intervention group or conventional therapy group. Event-related potentials (ERPs) and electromyography (EMG) were used to simultaneously record the cortical excitability and muscle activities during palmar grasp motion. Outcome measures of the contingent negative variation (CNV) latency and amplitude, EMG reaction time, Upper Limb Fugl-Meyer Assessment (UL-FMA), Action Research Arm Test (ARAT), and National Institutes of Health Stroke Scale (NIHSS) were recorded pre- and postintervention. The between-group difference was analysed by mixed model ANOVA. Results. The EMG onset time of the paretic hand in the VR group was earlier than that observed in the control group (t=2.174, p=0.039) postintervention. CNV latency reduction postintervention was larger in the VR group than in the control group (t=2.411, p=0.021) during paretic hand movement. The reduction in CNV amplitude in the VR group was larger in the VR group than in the control group (p<0.001 for all electrodes except for C3) when executing paretic hand movement. ARAT and UL-FMA scores were significantly higher in the VR group than in the control group (p=0.019 and p=0.037, respectively) postintervention. No significant difference in the reduction in NIHSS was found between the VR and control groups (p=0.072). Conclusions. VR intervention is superior to conventional therapy to improve the cognitive neural process of motor anticipation and reduce the excessive compensatory activation of the contralesional hemisphere. The improvements observed in the cognitive neural process corroborated with the improvements in hand function.http://dx.doi.org/10.1155/2022/7399995 |
| spellingShingle | Ling Chen Yi Chen Wen Bin Fu Dong Feng Huang Wai Leung Ambrose Lo The Effect of Virtual Reality on Motor Anticipation and Hand Function in Patients with Subacute Stroke: A Randomized Trial on Movement-Related Potential Neural Plasticity |
| title | The Effect of Virtual Reality on Motor Anticipation and Hand Function in Patients with Subacute Stroke: A Randomized Trial on Movement-Related Potential |
| title_full | The Effect of Virtual Reality on Motor Anticipation and Hand Function in Patients with Subacute Stroke: A Randomized Trial on Movement-Related Potential |
| title_fullStr | The Effect of Virtual Reality on Motor Anticipation and Hand Function in Patients with Subacute Stroke: A Randomized Trial on Movement-Related Potential |
| title_full_unstemmed | The Effect of Virtual Reality on Motor Anticipation and Hand Function in Patients with Subacute Stroke: A Randomized Trial on Movement-Related Potential |
| title_short | The Effect of Virtual Reality on Motor Anticipation and Hand Function in Patients with Subacute Stroke: A Randomized Trial on Movement-Related Potential |
| title_sort | effect of virtual reality on motor anticipation and hand function in patients with subacute stroke a randomized trial on movement related potential |
| url | http://dx.doi.org/10.1155/2022/7399995 |
| work_keys_str_mv | AT lingchen theeffectofvirtualrealityonmotoranticipationandhandfunctioninpatientswithsubacutestrokearandomizedtrialonmovementrelatedpotential AT yichen theeffectofvirtualrealityonmotoranticipationandhandfunctioninpatientswithsubacutestrokearandomizedtrialonmovementrelatedpotential AT wenbinfu theeffectofvirtualrealityonmotoranticipationandhandfunctioninpatientswithsubacutestrokearandomizedtrialonmovementrelatedpotential AT dongfenghuang theeffectofvirtualrealityonmotoranticipationandhandfunctioninpatientswithsubacutestrokearandomizedtrialonmovementrelatedpotential AT waileungambroselo theeffectofvirtualrealityonmotoranticipationandhandfunctioninpatientswithsubacutestrokearandomizedtrialonmovementrelatedpotential AT lingchen effectofvirtualrealityonmotoranticipationandhandfunctioninpatientswithsubacutestrokearandomizedtrialonmovementrelatedpotential AT yichen effectofvirtualrealityonmotoranticipationandhandfunctioninpatientswithsubacutestrokearandomizedtrialonmovementrelatedpotential AT wenbinfu effectofvirtualrealityonmotoranticipationandhandfunctioninpatientswithsubacutestrokearandomizedtrialonmovementrelatedpotential AT dongfenghuang effectofvirtualrealityonmotoranticipationandhandfunctioninpatientswithsubacutestrokearandomizedtrialonmovementrelatedpotential AT waileungambroselo effectofvirtualrealityonmotoranticipationandhandfunctioninpatientswithsubacutestrokearandomizedtrialonmovementrelatedpotential |