Comparing High-Intensity Interval Training (HIIT) and Continuous Training on Apelin, APJ, NO, and Cardiotrophin-1 in Cardiac Tissue of Diabetic Rats
Background and Aims. Exercise activity is an important method for managing type 2 diabetes. This investigation examined the HIIT and continuous training on apelin, APJ receptor, NO, and cardiotrophin-1 in the cardiac tissue of diabetic rats. Methods. The animals were categorized into 3 groups of HII...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/1472514 |
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| author | Mostafa Sabouri Javad Norouzi Yashar Zarei Mojtaba Hassani Sangani Babak Hooshmand Moghadam |
| author_facet | Mostafa Sabouri Javad Norouzi Yashar Zarei Mojtaba Hassani Sangani Babak Hooshmand Moghadam |
| author_sort | Mostafa Sabouri |
| collection | DOAJ |
| description | Background and Aims. Exercise activity is an important method for managing type 2 diabetes. This investigation examined the HIIT and continuous training on apelin, APJ receptor, NO, and cardiotrophin-1 in the cardiac tissue of diabetic rats. Methods. The animals were categorized into 3 groups of HIIT, continuous (CO), and control (C) (all animals were sacrificed immediately and 2 days after exercise training period). Rats underwent the treadmill exercise program either HIIT (12 bouts at 90–95% of VO2 max with 60 s rest at 50% of VO2 max) or CO (60–65% VO2 max for 40 min). Protocols performed 5 days per week for 8 weeks. Apelin, APJ receptor, NO, and cardiotrophin-1 protein expressions were measured using the Western blotting method in the left ventricle. Results. Immediately after HIIT and CO exercise protocols, apelin and CT-1 protein showed a significant difference in contrast by the C-0 group (p<0.01). However, NO values were substantially higher in HIIT-0 compared to C-0 and CO-0 groups rats (p<0.01). After two days of exercise protocols, apelin and NO protein showed a significant increase in HIIT and CO groups in contrast to the C animals (p<0.01). Moreover, APJ and CT-1 protein significantly upregulated in CO-2 and HIIT-2 compared to the other groups (p<0.01). Conclusions. This study indicates that exercise training, despite the type, is an efficient method to modify apelin, APJ receptor, NO, and cardiotrophin-1 values in animals with type 2 diabetes. |
| format | Article |
| id | doaj-art-69ad0418020f4d5f9ff68ae124ff86a2 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-69ad0418020f4d5f9ff68ae124ff86a22025-02-03T00:58:42ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/14725141472514Comparing High-Intensity Interval Training (HIIT) and Continuous Training on Apelin, APJ, NO, and Cardiotrophin-1 in Cardiac Tissue of Diabetic RatsMostafa Sabouri0Javad Norouzi1Yashar Zarei2Mojtaba Hassani Sangani3Babak Hooshmand Moghadam4Department of Exercise Physiology & Health Science, University of Tehran, Tehran, IranDepartment of Exercise Physiology & Health Science, University of Tehran, Tehran, IranDepartment of Exercise Physiology & Health Science, University of Tehran, Tehran, IranDepartment of Exercise Physiology & Health Science, University of Tehran, Tehran, IranDepartment of Exercise Physiology & Health Science, University of Tehran, Tehran, IranBackground and Aims. Exercise activity is an important method for managing type 2 diabetes. This investigation examined the HIIT and continuous training on apelin, APJ receptor, NO, and cardiotrophin-1 in the cardiac tissue of diabetic rats. Methods. The animals were categorized into 3 groups of HIIT, continuous (CO), and control (C) (all animals were sacrificed immediately and 2 days after exercise training period). Rats underwent the treadmill exercise program either HIIT (12 bouts at 90–95% of VO2 max with 60 s rest at 50% of VO2 max) or CO (60–65% VO2 max for 40 min). Protocols performed 5 days per week for 8 weeks. Apelin, APJ receptor, NO, and cardiotrophin-1 protein expressions were measured using the Western blotting method in the left ventricle. Results. Immediately after HIIT and CO exercise protocols, apelin and CT-1 protein showed a significant difference in contrast by the C-0 group (p<0.01). However, NO values were substantially higher in HIIT-0 compared to C-0 and CO-0 groups rats (p<0.01). After two days of exercise protocols, apelin and NO protein showed a significant increase in HIIT and CO groups in contrast to the C animals (p<0.01). Moreover, APJ and CT-1 protein significantly upregulated in CO-2 and HIIT-2 compared to the other groups (p<0.01). Conclusions. This study indicates that exercise training, despite the type, is an efficient method to modify apelin, APJ receptor, NO, and cardiotrophin-1 values in animals with type 2 diabetes.http://dx.doi.org/10.1155/2020/1472514 |
| spellingShingle | Mostafa Sabouri Javad Norouzi Yashar Zarei Mojtaba Hassani Sangani Babak Hooshmand Moghadam Comparing High-Intensity Interval Training (HIIT) and Continuous Training on Apelin, APJ, NO, and Cardiotrophin-1 in Cardiac Tissue of Diabetic Rats Journal of Diabetes Research |
| title | Comparing High-Intensity Interval Training (HIIT) and Continuous Training on Apelin, APJ, NO, and Cardiotrophin-1 in Cardiac Tissue of Diabetic Rats |
| title_full | Comparing High-Intensity Interval Training (HIIT) and Continuous Training on Apelin, APJ, NO, and Cardiotrophin-1 in Cardiac Tissue of Diabetic Rats |
| title_fullStr | Comparing High-Intensity Interval Training (HIIT) and Continuous Training on Apelin, APJ, NO, and Cardiotrophin-1 in Cardiac Tissue of Diabetic Rats |
| title_full_unstemmed | Comparing High-Intensity Interval Training (HIIT) and Continuous Training on Apelin, APJ, NO, and Cardiotrophin-1 in Cardiac Tissue of Diabetic Rats |
| title_short | Comparing High-Intensity Interval Training (HIIT) and Continuous Training on Apelin, APJ, NO, and Cardiotrophin-1 in Cardiac Tissue of Diabetic Rats |
| title_sort | comparing high intensity interval training hiit and continuous training on apelin apj no and cardiotrophin 1 in cardiac tissue of diabetic rats |
| url | http://dx.doi.org/10.1155/2020/1472514 |
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