Epidemiological trends and age-period-cohort effects on ischemic stroke burden across the BRICS-plus from 1992 to 2021
Abstract Background Ischemic stroke, accounting for 85% of stroke cases, leads to severe disabilities and increased mortality. Its global incidence rose by 87.55% from 1990 to 2019, posing significant health and economic burdens. The BRICS-plus nations—Brazil, Russia, India, China, South Africa, and...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12889-025-21310-9 |
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| author | Fangqun Cheng Peiyu Cheng Shudong Xie Hailing Wang Ying Tang Ying Liu Zhuo Xiao Guixiang Zhang Guangxiong Yuan Ke Wang Can Feng Ying Zhou Hong Xia Yan Wang Yuhang Wu |
| author_facet | Fangqun Cheng Peiyu Cheng Shudong Xie Hailing Wang Ying Tang Ying Liu Zhuo Xiao Guixiang Zhang Guangxiong Yuan Ke Wang Can Feng Ying Zhou Hong Xia Yan Wang Yuhang Wu |
| author_sort | Fangqun Cheng |
| collection | DOAJ |
| description | Abstract Background Ischemic stroke, accounting for 85% of stroke cases, leads to severe disabilities and increased mortality. Its global incidence rose by 87.55% from 1990 to 2019, posing significant health and economic burdens. The BRICS-plus nations—Brazil, Russia, India, China, South Africa, and five others—represent a large global population, presenting unique public health challenges. This study aims to evaluate the epidemiological trends and variations in the burden of ischemic stroke across BRICS-plus nations in a timely manner. Methods Data on the number, all-age rate, age-standardized rate, and relative change in ischemic stroke disability-adjusted life years (DALYs) from 1992 to 2021 within BRICS-plus were obtained from the Global Burden of Disease Study (GBD) 2021. Relationships between the DALYs rate and the Socio-demographic Index (SDI) were evaluated using Pearson correlation analyses. Additionally, age-period-cohort modeling was employed to estimate net drift, local drift, age, period, and cohort effects over the past three decades. Results From 1992 to 2021, total DALYs due to ischemic stroke increased by 47.14%, while the age-standardized DALYs rate decreased by 33.79%. All BRICS-plus countries exhibited a declining trend in the age-standardized DALYs rate over the past three decades. Egypt reported the highest age-standardized DALYs rate (2,462.60 per 100,000 population) in 2021, whereas the most substantial reduction of 59.37% was observed in Brazil. The annual net drift in the ischemic stroke DALYs rate ranged from -3.04% for Brazil to -0.48% for Egypt among the ten countries. A significant positive correlation was observed between the DALYs rate of ischemic stroke and SDI values. Countries exhibited similar age effect patterns, with an increasing risk of DALYs rate with advancing age. Period and cohort effects highlighted declines in observed nations, indicating improved ischemic stroke management strategies. Conclusion The burden of ischemic stroke showed an overall declining trend across the BRICS-plus from 1992 to 2021, but persistent health inequalities between these countries were driven by socioeconomic disparities. Furthermore, it emphasizes the necessity for targeted interventions across age, period, and cohort dimensions to address the distinct challenges posed by ischemic stroke in these rapidly developing countries. |
| format | Article |
| id | doaj-art-69a3e80fd2b444bfaf70d5c3f849671f |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-69a3e80fd2b444bfaf70d5c3f849671f2025-01-19T12:42:15ZengBMCBMC Public Health1471-24582025-01-0125111310.1186/s12889-025-21310-9Epidemiological trends and age-period-cohort effects on ischemic stroke burden across the BRICS-plus from 1992 to 2021Fangqun Cheng0Peiyu Cheng1Shudong Xie2Hailing Wang3Ying Tang4Ying Liu5Zhuo Xiao6Guixiang Zhang7Guangxiong Yuan8Ke Wang9Can Feng10Ying Zhou11Hong Xia12Yan Wang13Yuhang Wu14Xiangtan Central HospitalXiangtan Central HospitalTransplantation Center, The Third Xiangya Hospital, Central South UniversityXiangtan Central HospitalXiangtan Central HospitalXiangtan Central HospitalXiangtan Central HospitalXiangtan Central HospitalXiangtan Central HospitalXiangtan Central HospitalXiangtan Central HospitalXiangtan Central HospitalXiangtan Central HospitalXiangtan Central HospitalDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South UniversityAbstract Background Ischemic stroke, accounting for 85% of stroke cases, leads to severe disabilities and increased mortality. Its global incidence rose by 87.55% from 1990 to 2019, posing significant health and economic burdens. The BRICS-plus nations—Brazil, Russia, India, China, South Africa, and five others—represent a large global population, presenting unique public health challenges. This study aims to evaluate the epidemiological trends and variations in the burden of ischemic stroke across BRICS-plus nations in a timely manner. Methods Data on the number, all-age rate, age-standardized rate, and relative change in ischemic stroke disability-adjusted life years (DALYs) from 1992 to 2021 within BRICS-plus were obtained from the Global Burden of Disease Study (GBD) 2021. Relationships between the DALYs rate and the Socio-demographic Index (SDI) were evaluated using Pearson correlation analyses. Additionally, age-period-cohort modeling was employed to estimate net drift, local drift, age, period, and cohort effects over the past three decades. Results From 1992 to 2021, total DALYs due to ischemic stroke increased by 47.14%, while the age-standardized DALYs rate decreased by 33.79%. All BRICS-plus countries exhibited a declining trend in the age-standardized DALYs rate over the past three decades. Egypt reported the highest age-standardized DALYs rate (2,462.60 per 100,000 population) in 2021, whereas the most substantial reduction of 59.37% was observed in Brazil. The annual net drift in the ischemic stroke DALYs rate ranged from -3.04% for Brazil to -0.48% for Egypt among the ten countries. A significant positive correlation was observed between the DALYs rate of ischemic stroke and SDI values. Countries exhibited similar age effect patterns, with an increasing risk of DALYs rate with advancing age. Period and cohort effects highlighted declines in observed nations, indicating improved ischemic stroke management strategies. Conclusion The burden of ischemic stroke showed an overall declining trend across the BRICS-plus from 1992 to 2021, but persistent health inequalities between these countries were driven by socioeconomic disparities. Furthermore, it emphasizes the necessity for targeted interventions across age, period, and cohort dimensions to address the distinct challenges posed by ischemic stroke in these rapidly developing countries.https://doi.org/10.1186/s12889-025-21310-9Ischemic strokeDisability-adjusted life yearsAge-period-cohort modelBRICSTrends |
| spellingShingle | Fangqun Cheng Peiyu Cheng Shudong Xie Hailing Wang Ying Tang Ying Liu Zhuo Xiao Guixiang Zhang Guangxiong Yuan Ke Wang Can Feng Ying Zhou Hong Xia Yan Wang Yuhang Wu Epidemiological trends and age-period-cohort effects on ischemic stroke burden across the BRICS-plus from 1992 to 2021 BMC Public Health Ischemic stroke Disability-adjusted life years Age-period-cohort model BRICS Trends |
| title | Epidemiological trends and age-period-cohort effects on ischemic stroke burden across the BRICS-plus from 1992 to 2021 |
| title_full | Epidemiological trends and age-period-cohort effects on ischemic stroke burden across the BRICS-plus from 1992 to 2021 |
| title_fullStr | Epidemiological trends and age-period-cohort effects on ischemic stroke burden across the BRICS-plus from 1992 to 2021 |
| title_full_unstemmed | Epidemiological trends and age-period-cohort effects on ischemic stroke burden across the BRICS-plus from 1992 to 2021 |
| title_short | Epidemiological trends and age-period-cohort effects on ischemic stroke burden across the BRICS-plus from 1992 to 2021 |
| title_sort | epidemiological trends and age period cohort effects on ischemic stroke burden across the brics plus from 1992 to 2021 |
| topic | Ischemic stroke Disability-adjusted life years Age-period-cohort model BRICS Trends |
| url | https://doi.org/10.1186/s12889-025-21310-9 |
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