Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers
In this study, heparinized multifunctional mesoporous silica nanoparticles were successfully synthesized and characterized. The new material not only maintains intrinsic functions of bare magnetic and fluorescent mesoporous silica materials such as targeting, imaging, and sustained release of drugs,...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/430459 |
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| _version_ | 1832556471407083520 |
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| author | Yongxiang Zhang Xinmin Liu Yizhong Lu Jincai Wang Tingfang Dong Xiaohong Liu |
| author_facet | Yongxiang Zhang Xinmin Liu Yizhong Lu Jincai Wang Tingfang Dong Xiaohong Liu |
| author_sort | Yongxiang Zhang |
| collection | DOAJ |
| description | In this study, heparinized multifunctional mesoporous silica nanoparticles were successfully synthesized and characterized. The new material not only maintains intrinsic functions of bare magnetic and fluorescent mesoporous silica materials such as targeting, imaging, and sustained release of drugs, but also generates several novel activities such as the enhancement of biocompatibility, selective loading drugs, and dual loading of anticancer drug and bFGF, rendering it a promising candidate to be used as a multifunctional carrier. The strategy of combination of multifunctional mesoporous silica materials with bioactive molecules could be a new effective approach to improve their capabilities in the drug delivery. |
| format | Article |
| id | doaj-art-699f775d16c34beca7f7e66dbf075def |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-699f775d16c34beca7f7e66dbf075def2025-02-03T05:45:13ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/430459430459Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug CarriersYongxiang Zhang0Xinmin Liu1Yizhong Lu2Jincai Wang3Tingfang Dong4Xiaohong Liu5The First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453100, ChinaThe First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453100, ChinaThe First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453100, ChinaThe First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453100, ChinaThe First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453100, ChinaThe First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453100, ChinaIn this study, heparinized multifunctional mesoporous silica nanoparticles were successfully synthesized and characterized. The new material not only maintains intrinsic functions of bare magnetic and fluorescent mesoporous silica materials such as targeting, imaging, and sustained release of drugs, but also generates several novel activities such as the enhancement of biocompatibility, selective loading drugs, and dual loading of anticancer drug and bFGF, rendering it a promising candidate to be used as a multifunctional carrier. The strategy of combination of multifunctional mesoporous silica materials with bioactive molecules could be a new effective approach to improve their capabilities in the drug delivery.http://dx.doi.org/10.1155/2013/430459 |
| spellingShingle | Yongxiang Zhang Xinmin Liu Yizhong Lu Jincai Wang Tingfang Dong Xiaohong Liu Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers Journal of Chemistry |
| title | Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers |
| title_full | Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers |
| title_fullStr | Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers |
| title_full_unstemmed | Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers |
| title_short | Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers |
| title_sort | fabrication of heparinized mesoporous silica nanoparticles as multifunctional drug carriers |
| url | http://dx.doi.org/10.1155/2013/430459 |
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